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View Protein Complex Details

Complex Overview

From Publication: Mewes, H. W. et al. MIPS: Analysis and annotation of proteins from whole genomes. Nucleic Acids Res. 32, D41-D44
Notes: MIPS hand-curated complex set. MIPS complex ID: 410.20
Complex Size: 8 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CDC7
  • nucleus
  • Dbf4-dependent protein kinase complex
  • DNA replication initiation
  • protein amino acid phosphorylation
  • protein serine/threonine kinase activity
  • DBF4
  • Dbf4-dependent protein kinase complex
  • DNA replication initiation
  • positive regulation of protein kinase activity
  • DNA replication origin binding
  • protein serine/threonine kinase activator activity
  • ORC1
  • pre-replicative complex
  • nuclear origin of replication recognition complex
  • DNA replication initiation
  • pre-replicative complex assembly
  • chromatin silencing at silent mating-type cassette
  • ATPase activity
  • DNA replication origin binding
  • ORC2
  • pre-replicative complex
  • nuclear origin of replication recognition complex
  • DNA replication initiation
  • pre-replicative complex assembly
  • chromatin silencing at silent mating-type cassette
  • DNA replication origin binding
  • ORC3
  • pre-replicative complex
  • nuclear origin of replication recognition complex
  • DNA replication initiation
  • pre-replicative complex assembly
  • chromatin silencing at silent mating-type cassette
  • DNA replication origin binding
  • ORC4
  • pre-replicative complex
  • nuclear origin of replication recognition complex
  • DNA replication initiation
  • pre-replicative complex assembly
  • chromatin silencing at silent mating-type cassette
  • DNA replication origin binding
  • ORC5
  • pre-replicative complex
  • nuclear origin of replication recognition complex
  • DNA replication initiation
  • pre-replicative complex assembly
  • chromatin silencing at silent mating-type cassette
  • ATPase activity
  • DNA replication origin binding
  • ORC6
  • pre-replicative complex
  • nuclear origin of replication recognition complex
  • DNA replication initiation
  • pre-replicative complex assembly
  • chromatin silencing at silent mating-type cassette
  • DNA replication origin binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    origin recognition complex 3.2568E-19 8 6 6 6292
    nuclear origin of replication recognition complex 3.2568E-19 8 6 6 6292
    pre-replicative complex 2.601E-15 8 16 6 6292
    protein-DNA complex 1.1655E-11 8 57 6 6292
    nuclear chromosome part 1.8676E-8 8 190 6 6292
    nuclear chromosome 5.5921E-8 8 228 6 6292
    chromosomal part 7.0544E-8 8 237 6 6292
    nucleoplasm part 8.6079E-8 8 245 6 6292
    nucleoplasm 1.3463E-7 8 264 6 6292
    chromosome 1.6815E-7 8 274 6 6292
    protein complex 1.1143E-6 8 1137 8 6292
    Dbf4-dependent protein kinase complex 1.4147E-6 8 2 2 6292
    nuclear lumen 3.3344E-6 8 453 6 6292
    macromolecular complex 2.0527E-5 8 1635 8 6292
    organelle lumen 3.0323E-5 8 660 6 6292
    intracellular organelle lumen 3.0323E-5 8 660 6 6292
    membrane-enclosed lumen 4.2703E-5 8 700 6 6292
    non-membrane-bounded organelle 2.6233E-4 8 959 6 6292
    intracellular non-membrane-bounded organelle 2.6233E-4 8 959 6 6292
    nuclear part 5.8147E-4 8 1103 6 6292
    nucleus 2.1521E-3 8 2041 7 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    DNA replication initiation 2.2891E-19 8 33 8 6292
    pre-replicative complex assembly 5.578E-16 8 13 6 6292
    DNA-dependent DNA replication 5.8762E-16 8 82 8 6292
    DNA replication 1.698E-14 8 123 8 6292
    chromatin silencing at silent mating-type cassette 3.5806E-13 8 33 6 6292
    protein-DNA complex assembly 1.053E-12 8 39 6 6292
    negative regulation of gene expression, epigenetic 3.7834E-10 8 100 6 6292
    chromatin silencing 3.7834E-10 8 100 6 6292
    gene silencing 3.7834E-10 8 100 6 6292
    regulation of gene expression, epigenetic 3.7834E-10 8 100 6 6292
    DNA metabolic process 5.3456E-9 8 585 8 6292
    negative regulation of transcription, DNA-dependent 5.8994E-9 8 157 6 6292
    negative regulation of RNA metabolic process 6.1305E-9 8 158 6 6292
    negative regulation of gene expression 7.6813E-9 8 164 6 6292
    negative regulation of transcription 7.6813E-9 8 164 6 6292
    negative regulation of macromolecule biosynthetic process 1.1372E-8 8 175 6 6292
    negative regulation of nitrogen compound metabolic process 1.348E-8 8 180 6 6292
    negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.348E-8 8 180 6 6292
    cellular macromolecular complex assembly 1.4409E-8 8 182 6 6292
    negative regulation of biosynthetic process 1.8092E-8 8 189 6 6292
    negative regulation of cellular biosynthetic process 1.8092E-8 8 189 6 6292
    negative regulation of macromolecule metabolic process 1.9893E-8 8 192 6 6292
    negative regulation of cellular metabolic process 3.3152E-8 8 209 6 6292
    negative regulation of metabolic process 3.4118E-8 8 210 6 6292
    negative regulation of cellular process 9.7156E-8 8 250 6 6292
    negative regulation of biological process 1.0435E-7 8 253 6 6292
    cellular macromolecular complex subunit organization 1.2007E-7 8 259 6 6292
    macromolecular complex assembly 1.9551E-7 8 281 6 6292
    regulation of cellular metabolic process 2.3274E-7 8 536 7 6292
    regulation of metabolic process 2.6807E-7 8 547 7 6292
    macromolecular complex subunit organization 8.1386E-7 8 357 6 6292
    regulation of transcription, DNA-dependent 8.2749E-7 8 358 6 6292
    regulation of RNA metabolic process 8.9854E-7 8 363 6 6292
    regulation of transcription 1.2545E-6 8 384 6 6292
    cellular component assembly 1.274E-6 8 385 6 6292
    cellular macromolecule biosynthetic process 1.5738E-6 8 1187 8 6292
    macromolecule biosynthetic process 1.5953E-6 8 1189 8 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.9869E-6 8 415 6 6292
    regulation of nitrogen compound metabolic process 2.0153E-6 8 416 6 6292
    regulation of gene expression 3.0015E-6 8 445 6 6292
    regulation of macromolecule biosynthetic process 3.4669E-6 8 456 6 6292
    regulation of cellular process 3.609E-6 8 796 7 6292
    regulation of cellular biosynthetic process 4.2489E-6 8 472 6 6292
    regulation of biosynthetic process 4.3022E-6 8 473 6 6292
    regulation of biological process 4.5811E-6 8 824 7 6292
    regulation of macromolecule metabolic process 5.171E-6 8 488 6 6292
    transcription, DNA-dependent 6.1796E-6 8 503 6 6292
    nucleic acid metabolic process 6.4427E-6 8 1415 8 6292
    RNA biosynthetic process 6.5498E-6 8 508 6 6292
    regulation of primary metabolic process 7.018E-6 8 514 6 6292
    transcription 1.0669E-5 8 552 6 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.4527E-5 8 1566 8 6292
    cellular biosynthetic process 1.4602E-5 8 1567 8 6292
    biosynthetic process 1.7431E-5 8 1602 8 6292
    cellular nitrogen compound metabolic process 3.8773E-5 8 1770 8 6292
    cellular component biogenesis 4.0619E-5 8 694 6 6292
    nitrogen compound metabolic process 4.2618E-5 8 1791 8 6292
    biological regulation 6.4966E-5 8 1213 7 6292
    RNA metabolic process 2.5461E-4 8 954 6 6292
    cellular macromolecule metabolic process 3.0018E-4 8 2285 8 6292
    macromolecule metabolic process 3.7455E-4 8 2349 8 6292
    gene expression 1.3613E-3 8 1283 6 6292
    primary metabolic process 2.0036E-3 8 2896 8 6292
    cellular metabolic process 2.9013E-3 8 3033 8 6292
    metabolic process 3.9991E-3 8 3157 8 6292
    cellular component organization 4.336E-3 8 1582 6 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    DNA replication origin binding 1.7767E-19 8 13 7 6292
    sequence-specific DNA binding 1.0288E-14 8 50 7 6292
    DNA binding 1.3166E-9 8 256 7 6292
    nucleic acid binding 1.0515E-6 8 666 7 6292
    binding 1.0087E-4 8 1294 7 6292
    protein serine/threonine kinase activator activity 2.5415E-3 8 2 1 6292

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