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Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 8 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
HAT1
  • nucleus
  • cytoplasm
  • histone acetyltransferase complex
  • histone acetylation
  • chromatin silencing at telomere
  • histone binding
  • HAT2
  • nucleus
  • cytoplasm
  • histone acetyltransferase complex
  • chromatin assembly or disassembly
  • histone acetylation
  • chromatin silencing at telomere
  • histone binding
  • ORC1
  • pre-replicative complex
  • nuclear origin of replication recognition complex
  • DNA replication initiation
  • pre-replicative complex assembly
  • chromatin silencing at silent mating-type cassette
  • ATPase activity
  • DNA replication origin binding
  • ORC2
  • pre-replicative complex
  • nuclear origin of replication recognition complex
  • DNA replication initiation
  • pre-replicative complex assembly
  • chromatin silencing at silent mating-type cassette
  • DNA replication origin binding
  • ORC3
  • pre-replicative complex
  • nuclear origin of replication recognition complex
  • DNA replication initiation
  • pre-replicative complex assembly
  • chromatin silencing at silent mating-type cassette
  • DNA replication origin binding
  • ORC4
  • pre-replicative complex
  • nuclear origin of replication recognition complex
  • DNA replication initiation
  • pre-replicative complex assembly
  • chromatin silencing at silent mating-type cassette
  • DNA replication origin binding
  • ORC5
  • pre-replicative complex
  • nuclear origin of replication recognition complex
  • DNA replication initiation
  • pre-replicative complex assembly
  • chromatin silencing at silent mating-type cassette
  • ATPase activity
  • DNA replication origin binding
  • ORC6
  • pre-replicative complex
  • nuclear origin of replication recognition complex
  • DNA replication initiation
  • pre-replicative complex assembly
  • chromatin silencing at silent mating-type cassette
  • DNA replication origin binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    origin recognition complex 3.2568E-19 8 6 6 6292
    nuclear origin of replication recognition complex 3.2568E-19 8 6 6 6292
    pre-replicative complex 2.601E-15 8 16 6 6292
    nucleoplasm part 4.7294E-12 8 245 8 6292
    nucleoplasm 8.6686E-12 8 264 8 6292
    protein-DNA complex 1.1655E-11 8 57 6 6292
    nuclear lumen 6.8142E-10 8 453 8 6292
    organelle lumen 1.4108E-8 8 660 8 6292
    intracellular organelle lumen 1.4108E-8 8 660 8 6292
    nuclear chromosome part 1.8676E-8 8 190 6 6292
    membrane-enclosed lumen 2.2645E-8 8 700 8 6292
    nuclear chromosome 5.5921E-8 8 228 6 6292
    chromosomal part 7.0544E-8 8 237 6 6292
    chromosome 1.6815E-7 8 274 6 6292
    nuclear part 8.7333E-7 8 1103 8 6292
    protein complex 1.1143E-6 8 1137 8 6292
    macromolecular complex 2.0527E-5 8 1635 8 6292
    nucleus 1.2145E-4 8 2041 8 6292
    non-membrane-bounded organelle 2.6233E-4 8 959 6 6292
    intracellular non-membrane-bounded organelle 2.6233E-4 8 959 6 6292
    organelle part 2.9704E-4 8 2282 8 6292
    intracellular organelle part 2.9704E-4 8 2282 8 6292
    histone acetyltransferase complex 1.303E-3 8 44 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    pre-replicative complex assembly 5.578E-16 8 13 6 6292
    negative regulation of gene expression, epigenetic 3.068E-15 8 100 8 6292
    chromatin silencing 3.068E-15 8 100 8 6292
    gene silencing 3.068E-15 8 100 8 6292
    regulation of gene expression, epigenetic 3.068E-15 8 100 8 6292
    negative regulation of transcription, DNA-dependent 1.2592E-13 8 157 8 6292
    negative regulation of RNA metabolic process 1.3264E-13 8 158 8 6292
    negative regulation of gene expression 1.7992E-13 8 164 8 6292
    negative regulation of transcription 1.7992E-13 8 164 8 6292
    negative regulation of macromolecule biosynthetic process 3.0579E-13 8 175 8 6292
    chromatin silencing at silent mating-type cassette 3.5806E-13 8 33 6 6292
    DNA replication initiation 3.5806E-13 8 33 6 6292
    negative regulation of nitrogen compound metabolic process 3.8485E-13 8 180 8 6292
    negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 3.8485E-13 8 180 8 6292
    negative regulation of biosynthetic process 5.7294E-13 8 189 8 6292
    negative regulation of cellular biosynthetic process 5.7294E-13 8 189 8 6292
    negative regulation of macromolecule metabolic process 6.5142E-13 8 192 8 6292
    protein-DNA complex assembly 1.053E-12 8 39 6 6292
    negative regulation of cellular metabolic process 1.2999E-12 8 209 8 6292
    negative regulation of metabolic process 1.3514E-12 8 210 8 6292
    negative regulation of cellular process 5.572E-12 8 250 8 6292
    negative regulation of biological process 6.1382E-12 8 253 8 6292
    regulation of transcription, DNA-dependent 1.0197E-10 8 358 8 6292
    DNA-dependent DNA replication 1.1169E-10 8 82 6 6292
    regulation of RNA metabolic process 1.1406E-10 8 363 8 6292
    regulation of transcription 1.7964E-10 8 384 8 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 3.3615E-10 8 415 8 6292
    regulation of nitrogen compound metabolic process 3.4274E-10 8 416 8 6292
    regulation of gene expression 5.9023E-10 8 445 8 6292
    regulation of macromolecule biosynthetic process 7.1867E-10 8 456 8 6292
    regulation of cellular biosynthetic process 9.4898E-10 8 472 8 6292
    regulation of biosynthetic process 9.6531E-10 8 473 8 6292
    regulation of macromolecule metabolic process 1.2415E-9 8 488 8 6292
    DNA replication 1.3402E-9 8 123 6 6292
    transcription, DNA-dependent 1.5844E-9 8 503 8 6292
    RNA biosynthetic process 1.7158E-9 8 508 8 6292
    regulation of primary metabolic process 1.8861E-9 8 514 8 6292
    regulation of cellular metabolic process 2.6433E-9 8 536 8 6292
    regulation of metabolic process 3.1131E-9 8 547 8 6292
    transcription 3.3497E-9 8 552 8 6292
    cellular macromolecular complex assembly 1.4409E-8 8 182 6 6292
    regulation of cellular process 6.3621E-8 8 796 8 6292
    regulation of biological process 8.3992E-8 8 824 8 6292
    cellular macromolecular complex subunit organization 1.2007E-7 8 259 6 6292
    macromolecular complex assembly 1.9551E-7 8 281 6 6292
    RNA metabolic process 2.7241E-7 8 954 8 6292
    macromolecular complex subunit organization 8.1386E-7 8 357 6 6292
    cellular component assembly 1.274E-6 8 385 6 6292
    cellular macromolecule biosynthetic process 1.5738E-6 8 1187 8 6292
    macromolecule biosynthetic process 1.5953E-6 8 1189 8 6292
    biological regulation 1.8727E-6 8 1213 8 6292
    gene expression 2.9372E-6 8 1283 8 6292
    nucleic acid metabolic process 6.4427E-6 8 1415 8 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.4527E-5 8 1566 8 6292
    cellular biosynthetic process 1.4602E-5 8 1567 8 6292
    DNA metabolic process 1.4992E-5 8 585 6 6292
    cellular component organization 1.5761E-5 8 1582 8 6292
    biosynthetic process 1.7431E-5 8 1602 8 6292
    cellular nitrogen compound metabolic process 3.8773E-5 8 1770 8 6292
    cellular component biogenesis 4.0619E-5 8 694 6 6292
    nitrogen compound metabolic process 4.2618E-5 8 1791 8 6292
    cellular macromolecule metabolic process 3.0018E-4 8 2285 8 6292
    macromolecule metabolic process 3.7455E-4 8 2349 8 6292
    histone acetylation 8.7221E-4 8 36 2 6292
    protein amino acid acetylation 1.4238E-3 8 46 2 6292
    primary metabolic process 2.0036E-3 8 2896 8 6292
    chromatin silencing at telomere 2.0312E-3 8 55 2 6292
    protein amino acid acylation 2.3343E-3 8 59 2 6292
    cellular metabolic process 2.9013E-3 8 3033 8 6292
    metabolic process 3.9991E-3 8 3157 8 6292
    covalent chromatin modification 5.1269E-3 8 88 2 6292
    histone modification 5.1269E-3 8 88 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    DNA replication origin binding 5.578E-16 8 13 6 6292
    sequence-specific DNA binding 5.1134E-12 8 50 6 6292
    DNA binding 1.1198E-7 8 256 6 6292
    binding 3.1454E-6 8 1294 8 6292
    nucleic acid binding 3.1964E-5 8 666 6 6292
    histone binding 1.2776E-4 8 14 2 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle