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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 17 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CIC1
  • proteasome complex
  • nucleolus
  • protein catabolic process
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • protein binding, bridging
  • DBP10
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • DRS1
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • ERB1
  • nucleus
  • nucleolus
  • rRNA processing
  • molecular_function
  • HAS1
  • nuclear envelope
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA binding
  • RNA-dependent ATPase activity
  • ATP-dependent RNA helicase activity
  • MRT4
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • telomere maintenance
  • ribosome biogenesis
  • rRNA processing
  • mRNA catabolic process
  • molecular_function
  • NOG1
  • nuclear outer membrane
  • nucleolus
  • preribosome, large subunit precursor
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • GTP binding
  • NOP15
  • nucleus
  • nucleolus
  • cytokinesis, actomyosin contractile ring assembly
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • ribosome assembly
  • molecular_function
  • NOP7
  • nucleus
  • nucleolus
  • cell proliferation
  • maturation of SSU-rRNA
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • cell cycle
  • molecular_function
  • NSA2
  • nucleus
  • preribosome, large subunit precursor
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • processing of 27S pre-rRNA
  • molecular_function
  • NUG1
  • nucleus
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • GTPase activity
  • RIX1
  • nucleus
  • nuclear outer membrane
  • nucleoplasm
  • ribosomal subunit export from nucleus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • molecular_function
  • RLP7
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • processing of 27S pre-rRNA
  • rRNA binding
  • RPF1
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • processing of 27S pre-rRNA
  • rRNA primary transcript binding
  • SDA1
  • nucleus
  • ribosome biogenesis
  • traversing start control point of mitotic cell cycle
  • ribosome assembly
  • actin cytoskeleton organization
  • molecular_function
  • TIF6
  • nucleus
  • cytoplasm
  • nuclear outer membrane
  • nucleolus
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • processing of 27S pre-rRNA
  • ribosomal large subunit binding
  • YTM1
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleolus 9.2374E-19 17 211 14 6292
    nuclear lumen 6.917E-16 17 453 15 6292
    organelle lumen 1.9704E-13 17 660 15 6292
    intracellular organelle lumen 1.9704E-13 17 660 15 6292
    membrane-enclosed lumen 4.7435E-13 17 700 15 6292
    nuclear part 4.0003E-10 17 1103 15 6292
    non-membrane-bounded organelle 1.4544E-9 17 959 14 6292
    intracellular non-membrane-bounded organelle 1.4544E-9 17 959 14 6292
    nucleus 4.6591E-9 17 2041 17 6292
    nuclear outer membrane 2.3077E-6 17 86 5 6292
    nuclear membrane 4.1958E-6 17 97 5 6292
    nuclear envelope 8.5869E-6 17 199 6 6292
    organelle part 1.429E-5 17 2282 15 6292
    intracellular organelle part 1.429E-5 17 2282 15 6292
    outer membrane 8.0401E-5 17 178 5 6292
    organelle outer membrane 8.0401E-5 17 178 5 6292
    membrane-bounded organelle 1.6371E-4 17 3771 17 6292
    intracellular membrane-bounded organelle 1.6371E-4 17 3771 17 6292
    preribosome, large subunit precursor 2.4464E-4 17 9 2 6292
    nuclear membrane-endoplasmic reticulum network 2.8078E-4 17 232 5 6292
    endomembrane system 4.1953E-4 17 398 6 6292
    intracellular organelle 6.0057E-4 17 4070 17 6292
    organelle 6.0308E-4 17 4071 17 6292
    envelope 1.4913E-3 17 505 6 6292
    organelle envelope 1.4913E-3 17 505 6 6292
    preribosome 3.6639E-3 17 34 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosomal large subunit biogenesis 9.8623E-24 17 65 13 6292
    ribosome biogenesis 2.6351E-22 17 346 17 6292
    ribonucleoprotein complex biogenesis 1.0198E-21 17 374 17 6292
    cellular component biogenesis 4.4392E-17 17 694 17 6292
    ribosome assembly 9.8901E-9 17 64 6 6292
    organelle assembly 1.5694E-8 17 69 6 6292
    processing of 27S pre-rRNA 6.5086E-8 17 16 4 6292
    ribonucleoprotein complex assembly 9.0163E-8 17 92 6 6292
    ribosomal large subunit assembly 3.4746E-6 17 41 4 6292
    cellular macromolecular complex assembly 5.1207E-6 17 182 6 6292
    ribosomal subunit assembly 1.1433E-5 17 55 4 6292
    obsolete_biological_process 1.6211E-5 17 60 4 6292
    rRNA processing 1.6387E-5 17 128 5 6292
    rRNA metabolic process 2.2806E-5 17 137 5 6292
    cellular macromolecular complex subunit organization 3.874E-5 17 259 6 6292
    establishment of ribosome localization 4.1E-5 17 26 3 6292
    ribosome localization 4.1E-5 17 26 3 6292
    ribosomal subunit export from nucleus 4.1E-5 17 26 3 6292
    macromolecular complex assembly 6.1355E-5 17 281 6 6292
    ncRNA processing 1.9661E-4 17 215 5 6292
    macromolecular complex subunit organization 2.3194E-4 17 357 6 6292
    cellular component assembly 3.5035E-4 17 385 6 6292
    establishment of organelle localization 3.9412E-4 17 55 3 6292
    ncRNA metabolic process 4.5163E-4 17 257 5 6292
    organelle localization 1.4112E-3 17 85 3 6292
    nuclear export 2.4518E-3 17 103 3 6292
    cellular process 2.5051E-3 17 4426 17 6292
    RNA processing 2.6434E-3 17 380 5 6292
    nuclear transport 4.7409E-3 17 130 3 6292
    nucleocytoplasmic transport 4.7409E-3 17 130 3 6292
    actomyosin structure organization 8.0849E-3 17 3 1 6292
    cytokinesis, actomyosin contractile ring assembly 8.0849E-3 17 3 1 6292
    assembly of actomyosin apparatus involved in cell cycle cytokinesis 8.0849E-3 17 3 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ATP-dependent RNA helicase activity 5.1487E-5 17 28 3 6292
    RNA-dependent ATPase activity 5.7332E-5 17 29 3 6292
    RNA helicase activity 1.7625E-4 17 42 3 6292
    ATP-dependent helicase activity 2.6289E-4 17 48 3 6292
    purine NTP-dependent helicase activity 2.6289E-4 17 48 3 6292
    rRNA binding 8.0644E-4 17 16 2 6292
    helicase activity 1.3172E-3 17 83 3 6292
    ribosomal large subunit binding 2.7018E-3 17 1 1 6292
    ATPase activity, coupled 6.9354E-3 17 149 3 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle