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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 15 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CIC1
  • proteasome complex
  • nucleolus
  • protein catabolic process
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • protein binding, bridging
  • DBP10
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • DRS1
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • HAS1
  • nuclear envelope
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA binding
  • RNA-dependent ATPase activity
  • ATP-dependent RNA helicase activity
  • MAK21
  • Noc1p-Noc2p complex
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • molecular_function
  • NOC2
  • nucleus
  • Noc2p-Noc3p complex
  • mitochondrion
  • Noc1p-Noc2p complex
  • ribosomal subunit export from nucleus
  • ribosome biogenesis
  • ribosome assembly
  • molecular_function
  • NOC3
  • nucleus
  • Noc2p-Noc3p complex
  • nucleolus
  • DNA replication initiation
  • ribosome biogenesis
  • rRNA processing
  • protein binding
  • chromatin binding
  • NOG1
  • nuclear outer membrane
  • nucleolus
  • preribosome, large subunit precursor
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • GTP binding
  • NOP15
  • nucleus
  • nucleolus
  • cytokinesis, actomyosin contractile ring assembly
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • ribosome assembly
  • molecular_function
  • NOP2
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA methyltransferase activity
  • S-adenosylmethionine-dependent methyltransferase activity
  • NOP7
  • nucleus
  • nucleolus
  • cell proliferation
  • maturation of SSU-rRNA
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • cell cycle
  • molecular_function
  • NUG1
  • nucleus
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • GTPase activity
  • PUF6
  • nucleus
  • nucleolus
  • regulation of transcription, mating-type specific
  • ribosome biogenesis
  • mRNA binding
  • specific transcriptional repressor activity
  • RPF2
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • processing of 27S pre-rRNA
  • 5S rRNA binding
  • 7S RNA binding
  • rRNA binding
  • TIF6
  • nucleus
  • cytoplasm
  • nuclear outer membrane
  • nucleolus
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • processing of 27S pre-rRNA
  • ribosomal large subunit binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleolus 4.6603E-23 15 211 15 6292
    nuclear lumen 5.8229E-18 15 453 15 6292
    organelle lumen 1.7741E-15 15 660 15 6292
    intracellular organelle lumen 1.7741E-15 15 660 15 6292
    membrane-enclosed lumen 4.3281E-15 15 700 15 6292
    non-membrane-bounded organelle 5.0689E-13 15 959 15 6292
    intracellular non-membrane-bounded organelle 5.0689E-13 15 959 15 6292
    nuclear part 4.193E-12 15 1103 15 6292
    preribosome, large subunit precursor 2.6178E-9 15 9 4 6292
    nucleus 4.4738E-8 15 2041 15 6292
    Noc complex 1.0934E-7 15 5 3 6292
    intracellular organelle part 2.3996E-7 15 2282 15 6292
    organelle part 2.3996E-7 15 2282 15 6292
    preribosome 9.3032E-7 15 34 4 6292
    Noc2p-Noc3p complex 5.3053E-6 15 2 2 6292
    Noc1p-Noc2p complex 5.3053E-6 15 2 2 6292
    nuclear outer membrane 3.9595E-5 15 86 4 6292
    nuclear membrane 6.3611E-5 15 97 4 6292
    nuclear envelope 6.9785E-5 15 199 5 6292
    nucleolar part 1.465E-4 15 45 3 6292
    membrane-bounded organelle 4.5726E-4 15 3771 15 6292
    intracellular membrane-bounded organelle 4.5726E-4 15 3771 15 6292
    outer membrane 6.6197E-4 15 178 4 6292
    organelle outer membrane 6.6197E-4 15 178 4 6292
    90S preribosome 7.0676E-4 15 17 2 6292
    intracellular organelle 1.4392E-3 15 4070 15 6292
    organelle 1.4445E-3 15 4071 15 6292
    endomembrane system 1.7459E-3 15 398 5 6292
    nuclear membrane-endoplasmic reticulum network 1.7834E-3 15 232 4 6292
    envelope 4.9781E-3 15 505 5 6292
    organelle envelope 4.9781E-3 15 505 5 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosome biogenesis 9.5036E-20 15 346 15 6292
    ribonucleoprotein complex biogenesis 3.1258E-19 15 374 15 6292
    ribosomal large subunit biogenesis 3.5997E-15 15 65 9 6292
    cellular component biogenesis 3.7988E-15 15 694 15 6292
    ribosome assembly 4.0637E-9 15 64 6 6292
    organelle assembly 6.4574E-9 15 69 6 6292
    ribonucleoprotein complex assembly 3.7332E-8 15 92 6 6292
    ribosomal large subunit assembly 2.0116E-6 15 41 4 6292
    cellular macromolecular complex assembly 2.1736E-6 15 182 6 6292
    ribosomal subunit assembly 6.6428E-6 15 55 4 6292
    rRNA processing 8.2175E-6 15 128 5 6292
    rRNA metabolic process 1.1464E-5 15 137 5 6292
    cellular macromolecular complex subunit organization 1.68E-5 15 259 6 6292
    macromolecular complex assembly 2.677E-5 15 281 6 6292
    establishment of ribosome localization 2.7585E-5 15 26 3 6292
    ribosome localization 2.7585E-5 15 26 3 6292
    ribosomal subunit export from nucleus 2.7585E-5 15 26 3 6292
    ncRNA processing 1.0091E-4 15 215 5 6292
    macromolecular complex subunit organization 1.0337E-4 15 357 6 6292
    cellular component assembly 1.5738E-4 15 385 6 6292
    ncRNA metabolic process 2.3443E-4 15 257 5 6292
    establishment of organelle localization 2.67E-4 15 55 3 6292
    processing of 27S pre-rRNA 6.2447E-4 15 16 2 6292
    organelle localization 9.6287E-4 15 85 3 6292
    RNA processing 1.4183E-3 15 380 5 6292
    nuclear export 1.6801E-3 15 103 3 6292
    nuclear transport 3.2694E-3 15 130 3 6292
    nucleocytoplasmic transport 3.2694E-3 15 130 3 6292
    cellular process 5.0732E-3 15 4426 15 6292
    actomyosin structure organization 7.136E-3 15 3 1 6292
    cytokinesis, actomyosin contractile ring assembly 7.136E-3 15 3 1 6292
    assembly of actomyosin apparatus involved in cell cycle cytokinesis 7.136E-3 15 3 1 6292
    obsolete_biological_process 8.6698E-3 15 60 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ATP-dependent RNA helicase activity 3.4657E-5 15 28 3 6292
    RNA-dependent ATPase activity 3.8601E-5 15 29 3 6292
    RNA helicase activity 1.1904E-4 15 42 3 6292
    ATP-dependent helicase activity 1.778E-4 15 48 3 6292
    purine NTP-dependent helicase activity 1.778E-4 15 48 3 6292
    helicase activity 8.9828E-4 15 83 3 6292
    ribosomal large subunit binding 2.384E-3 15 1 1 6292
    7S RNA binding 2.384E-3 15 1 1 6292
    5S rRNA binding 4.7627E-3 15 2 1 6292
    ATPase activity, coupled 4.8042E-3 15 149 3 6292
    nucleoside-triphosphatase activity 6.328E-3 15 329 4 6292
    hydrolase activity, acting on acid anhydrides 8.113E-3 15 353 4 6292
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 8.113E-3 15 353 4 6292
    pyrophosphatase activity 8.113E-3 15 353 4 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle