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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 13 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
BRX1
  • nucleolus
    		•
  • ribosome biogenesis
  • ribosomal large subunit assembly
    		•
  • 5S rRNA binding
  • rRNA primary transcript binding
    		•
    CIC1
  • proteasome complex
  • nucleolus
    		•
  • protein catabolic process
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
    		•
  • protein binding, bridging
    		•
    HAS1
  • nuclear envelope
  • nucleolus
    		•
  • ribosome biogenesis
  • rRNA processing
    		•
  • RNA binding
  • RNA-dependent ATPase activity
  • ATP-dependent RNA helicase activity
    		•
    MAK21
  • Noc1p-Noc2p complex
    		•
  • ribosome biogenesis
  • ribosomal large subunit assembly
    		•
  • molecular_function
    		•
    NOC2
  • nucleus
  • Noc2p-Noc3p complex
  • mitochondrion
  • Noc1p-Noc2p complex
    		•
  • ribosomal subunit export from nucleus
  • ribosome biogenesis
  • ribosome assembly
    		•
  • molecular_function
    		•
    NOG1
  • nuclear outer membrane
  • nucleolus
  • preribosome, large subunit precursor
    		•
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
    		•
  • GTP binding
    		•
    NOP12
  • nucleolus
    		•
  • rRNA metabolic process
    		•
  • RNA binding
    		•
    NOP2
  • nucleolus
    		•
  • ribosome biogenesis
  • rRNA processing
    		•
  • RNA methyltransferase activity
  • S-adenosylmethionine-dependent methyltransferase activity
    		•
    NOP4
  • nucleolus
    		•
  • ribosome biogenesis
  • rRNA processing
    		•
  • RNA binding
    		•
    PUF6
  • nucleus
  • nucleolus
    		•
  • regulation of transcription, mating-type specific
  • ribosome biogenesis
    		•
  • mRNA binding
  • specific transcriptional repressor activity
    		•
    RLP7
  • nucleolus
    		•
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • processing of 27S pre-rRNA
    		•
  • rRNA binding
    		•
    RRP12
  • nucleus
  • ribosome
    		•
  • maturation of SSU-rRNA
  • ribosome biogenesis
    		•
  • molecular_function
    		•
    YTM1
  • nucleus
  • nucleolus
    		•
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
    		•
  • molecular_function
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    nucleolus 1.8756E-17 13 211 12 6292
    nuclear lumen 2.0573E-13 13 453 12 6292
    organelle lumen 1.9073E-11 13 660 12 6292
    intracellular organelle lumen 1.9073E-11 13 660 12 6292
    non-membrane-bounded organelle 2.2351E-11 13 959 13 6292
    intracellular non-membrane-bounded organelle 2.2351E-11 13 959 13 6292
    membrane-enclosed lumen 3.8613E-11 13 700 12 6292
    nuclear part 8.749E-9 13 1103 12 6292
    nucleus 4.29E-7 13 2041 13 6292
    preribosome, large subunit precursor 5.7481E-7 13 9 3 6292
    Noc1p-Noc2p complex 3.9411E-6 13 2 2 6292
    Noc complex 3.9273E-5 13 5 2 6292
    preribosome 3.9744E-5 13 34 3 6292
    intracellular organelle part 4.4049E-5 13 2282 12 6292
    organelle part 4.4049E-5 13 2282 12 6292
    90S preribosome 5.2669E-4 13 17 2 6292
    membrane-bounded organelle 1.2767E-3 13 3771 13 6292
    intracellular membrane-bounded organelle 1.2767E-3 13 3771 13 6292
    intracellular organelle 3.4477E-3 13 4070 13 6292
    organelle 3.4587E-3 13 4071 13 6292
    nucleolar part 3.7109E-3 13 45 2 6292
    Noc2p-Noc3p complex 4.1283E-3 13 2 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    ribosome biogenesis 7.8761E-15 13 346 12 6292
    ribonucleoprotein complex biogenesis 2.0245E-14 13 374 12 6292
    cellular component biogenesis 3.4829E-11 13 694 12 6292
    ribosomal large subunit biogenesis 1.558E-9 13 65 6 6292
    rRNA metabolic process 5.089E-6 13 137 5 6292
    rRNA processing 1.0135E-4 13 128 4 6292
    ncRNA metabolic process 1.0748E-4 13 257 5 6292
    ribosome assembly 2.6697E-4 13 64 3 6292
    organelle assembly 3.3372E-4 13 69 3 6292
    ncRNA processing 7.4339E-4 13 215 4 6292
    ribonucleoprotein complex assembly 7.7815E-4 13 92 3 6292
    establishment of ribosome localization 1.2455E-3 13 26 2 6292
    ribosome localization 1.2455E-3 13 26 2 6292
    ribosomal subunit export from nucleus 1.2455E-3 13 26 2 6292
    ribosomal large subunit assembly 3.088E-3 13 41 2 6292
    cellular macromolecular complex assembly 5.4966E-3 13 182 3 6292
    ribosomal subunit assembly 5.5019E-3 13 55 2 6292
    establishment of organelle localization 5.5019E-3 13 55 2 6292
    RNA processing 6.0507E-3 13 380 4 6292
    RNA metabolic process 7.8824E-3 13 954 6 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    RNA binding 4.5706E-5 13 367 6 6292
    rRNA binding 4.6527E-4 13 16 2 6292
    nucleic acid binding 1.2273E-3 13 666 6 6292
    binding 1.4925E-3 13 1294 8 6292
    5S rRNA binding 4.1283E-3 13 2 1 6292
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle