YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: AKR1

General Information:
Name(s) found: AKR1 / YDR264C [SGD]
Description(s) found:
Found 30 descriptions.
SHOW ALL
  • Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 764 amino acids

    Gene Ontology:
    Cellular Component: membrane [IDALink to PubMed article]
    Biological Process: protein amino acid palmitoylation [IDALink to PubMed articleLink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    endocytosis [IMPLink to PubMed article]
    protein targeting to membrane [IMPLink to PubMed article]
    pheromone-dependent signal transduction involved in conjugation with cellular fusion [IGILink to PubMed article]
    Molecular Function: protein-cysteine S-palmitoleyltransferase activity [IDALink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVNELENVPR ASTLTNEEQT VDPSNNDSQE DISLGDSNEI TSLASLKAIR SGNEEESGNE  60
   61 QVNHNDEAEE DPLLTRYHTA CQRGDLATVK EMIHGKLLEV NNDGDSTEHI TGLHWASINN 120
  121 RLSVVDFLVS QGADVNARAG ALHATPLHWA ARYGYVYIVD FLLKHGADPT MTDDQGFNLL 180
  181 HLSVNSSNIM LVLYVLFNVV SKGLLDIDCR DPKGRTSLLW AAYQGDSLTV AELLKFGASI 240
  241 KIADTEGFTP LHWGTVKGQP HVLKYLIQDG ADFFQKTDTG KDCFAIAQEM NTVYSLREAL 300
  301 THSGFDYHGY PIKKWFKKSQ HAKLVTFITP FLFLGIAFAL FSHINPLFVI IVLFLLAIAT 360
  361 NKGLNKFVLP SYGRMGVHNV TLLRSPLLSG VFFGTLLWVT IVWFFKVMPR TFSDEQYTNI 420
  421 LMLVILVSVF YLFGQLVIMD PGCLPEETDH ENVRQTISNL LEIGKFDTKN FCIETWIRKP 480
  481 LRSKFSPLNN AVVARFDHYC PWIFNDVGLK NHKAFIFFIT LMESGIFTFL ALCLEYFDEL 540
  541 EDAHEDTSQK NGKCFILGAS DLCSGLIYDR FVFLILLWAL LQSIWVASLI FVQAFQICKG 600
  601 MTNTEFNVLM KESKSIGPDG LSFNENFNTT PEGFAPSIDP GEESNDTVLA PVPGSTIRKP 660
  661 RTCFGVCYAV TGMDQWLAVI KETIGIKDST GHNVYSITSR IPTNYGWKRN VKDFWLTSDI 720
  721 NAPLWRRILY PPSGSKALLN GIEVDYFKLY KLPNKDVEQG NDMV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) AKR1 SAC3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen FRT2 AKR1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data AKR1 and COP1 Huh WK, et al. (2003)
    View Data AKR1 and ANP1 Huh WK, et al. (2003)
    View Data AKR1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..170] PSI-BLAST 111.917458 bcl-3
    2 View Details [171..344] PSI-BLAST 111.917458 bcl-3
    3 View Details [345..653] MSA 31.228987 View MSA. No confident structure predictions are available.
    4 View Details [654..764] MSA 1.01396 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein binding
    		•  2.69918165732603 bayes_pls_golite062009
  • hydrolase activity
    		•  2.43232200709693 bayes_pls_golite062009
  • binding
    		•  2.17983095277661 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.93050618316228 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  1.29094941611102 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  1.23556500721571 bayes_pls_golite062009
  • transporter activity
    		•  1.19000052859754 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.02570255606772 bayes_pls_golite062009
  • structural molecule activity
    		•  0.808967137205604 bayes_pls_golite062009
  • receptor activity
    		•  0.794712986057462 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.789486768149117 bayes_pls_golite062009
  • signal transducer activity
    		•  0.789486768149117 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.694785132815586 bayes_pls_golite062009
  • enzyme binding
    		•  0.60140077251711 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.581121752453591 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.428839878681413 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.304692936026767 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  0.247967126091535 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.240863793118641 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.171334135216535 bayes_pls_golite062009
  • actin binding
    		•  0.168912685840912 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle