Protein Overview: LCK_RAT

General Information:
Name(s) found:	LCK_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|34871627\|ref\|XP_232763.2\| PREDICTED: similar to lymphocyte protein tyrosine kinase [Rattus norvegicus] [NCBI NR] gi\|229836106\|sp\|Q01621.3\|LCK_RAT RecName: Full=Proto-oncogene tyrosine-protein kinase LCK; AltName: Full=Lymphocyte cell-specific protein-tyrosine kinase; AltName: Full=p56-LCK [NCBI NR] gi\|189181659\|ref\|NP_001094179.1\| lymphocyte-specific protein tyrosine kinase [Rattus norvegicus] [NCBI NR] gi\|169642765\|gb\|AAI60881.1\| Lck protein [Rattus norvegicus] [NCBI NR] gi\|149024049\|gb\|EDL80546.1\| rCG30804 [Rattus norvegicus] [NCBI NR] gi\|109477324\|ref\|XP_001061773.1\| PREDICTED: similar to lymphocyte protein tyrosine kinase [Rattus norvegicus] [NCBI NR] Proto-oncogene tyrosine-protein kinase LCK OS=Rattus norvegicus GN=Lck PE=1 SV=3 [Swiss-Prot] lymphocyte-specific protein tyrosine kinase [HMR_022704-rand.fasta] lymphocyte-specific protein tyrosine kinase [Rattus norvegicus] [nrdb_11152004_Chlamydomonas] Tax_Id=10116 PREDICTED: lymphocyte protein tyrosine kinase [EBI-IPI_rat_3.13_12-01-2005_con_reversed.fasta] Tax_Id=10116 Lymphocyte-specific protein tyrosine kinase [EBI-IPI_rat_3.05_04-04-2005_origrev.fasta] Lck protein [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] lymphocyte protein tyrosine kinase [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] rCG30804 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 LYMPHOCYTE-SPECIFIC PROTEIN TYROSINE KINASE [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] PREDICTED: similar to lymphocyte protein tyrosine kinase [Rattus norvegicus] [nr-271106-contam.fasta] Tax_Id=10116 Gene_Symbol=Lck Proto-oncogene tyrosine-protein kinase LCK [rat-ipi-250309-contam.fasta] Proto-oncogene tyrosine-protein kinase LCK OS=Rattus norvegicus GN=Lck [011711_HMR.fasta] Proto-oncogene tyrosine-protein kinase LCK OS=Rattus norvegicus GN=Lck PE=2 SV=3 [UNIPROT_RAT_07-21-2011_reversed.fasta]
Organism:	Rattus norvegicus
Length:	509 amino acids
Gene Ontology:
Cellular Component:	pericentriolar material [UNKNOWN] endocytic vesicle [IDA] cytoplasm [UNKNOWN][IEA] membrane raft [UNKNOWN][IDA] cytosol [UNKNOWN] Golgi apparatus [UNKNOWN] plasma membrane [IDA]
Biological Process:	peptidyl-tyrosine phosphorylation [UNKNOWN][IDA] response to zinc ion [IEP] cellular zinc ion homeostasis [UNKNOWN] positive regulation of gamma-delta T cell differentiation [UNKNOWN][IEA] protein amino acid autophosphorylation [UNKNOWN][IDA] cell surface receptor linked signaling pathway [UNKNOWN][IEA] response to hydrogen peroxide [IDA] protein amino acid phosphorylation [UNKNOWN] aging [IEP] response to mechanical stimulus [IMP] T cell differentiation [UNKNOWN] positive regulation of T cell activation [UNKNOWN] positive regulation of uterine smooth muscle contraction [IMP] induction of apoptosis [UNKNOWN] response to drug [UNKNOWN] apoptosis [IEP] response to metal ion [IDA] regulation of T cell receptor signaling pathway [UNKNOWN][IEA] activation of caspase activity [UNKNOWN] release of sequestered calcium ion into cytosol [IEA] B cell receptor signaling pathway [UNKNOWN][IEA]
Molecular Function:	protein kinase binding [UNKNOWN] phosphoinositide 3-kinase binding [UNKNOWN] protein C-terminus binding [UNKNOWN] CD4 receptor binding [UNKNOWN] SH2 domain binding [UNKNOWN] CD8 receptor binding [UNKNOWN] nucleotide binding [IEA] protein serine/threonine phosphatase activity [UNKNOWN] ATP binding [IEA] protein tyrosine kinase activity [UNKNOWN][IDA] protein binding [UNKNOWN][IPI] non-membrane spanning protein tyrosine kinase activity [IEA] glycoprotein binding [UNKNOWN] transferase activity [IEA] protein complex binding [IDA] ATPase binding [UNKNOWN]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGCVCSSNPE DDWMENIDVC ENCHYPIVPL DSKSTLPIRT GSEVRDPLVT YEGSLPPASP  60
   61 LQDNLVIALH SYEPSHDGDL GFEKGEQLRI LEQSGEWWKA QSLTTGQEGF IPFNFVAKAN 120
  121 SLEPEPWFFK NLSRKDAERQ LLAPGNTHGS FLIRESESTA GSFSLSVRDF DQNQGEVVKH 180
  181 YKIRNLDNGG FYISPRITFP GLHDLVRHYT NASDGLCTKL SRPCQTQKPQ KPWWEDEWEV 240
  241 PRETLKLVER LGAGQFGEVW MGYYNGHTKV AVKSLKQGSM SPDAFLAEAN LMKQLQHPRL 300
  301 VRLYAVVTQE PIYIITEYME NGSLVDFLKT PSGIKLNVNK LLDMAAQIAE GMAFIEEQNY 360
  361 IHRDLRAANI LVSDTLSCKI ADFGLARLIE DNEYTAREGA KFPIKWTAPE AINYGTFTIK 420
  421 SDVWSFGILL TEIVTHGRIP YPGMTNPEVI QNLEKGYRMV RPDNCPEELY HLMMLCWKER 480
  481 PEDRPTFDYL RSVLDDFFTA TEGQYQPQP

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: LCK_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: