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Protein Overview: LCK_RAT

General Information:
Name(s) found: LCK_RAT [Swiss-Prot]
Description(s) found:
Found 19 descriptions.
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  • Proto-oncogene tyrosine-protein kinase LCK OS=Rattus norvegicus GN=Lck PE=1 SV=3 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 509 amino acids

    Gene Ontology:
    Cellular Component: pericentriolar material [UNKNOWN]
    endocytic vesicle [IDA]
    cytoplasm [UNKNOWN][IEA]
    membrane raft [UNKNOWN][IDA]
    cytosol [UNKNOWN]
    Golgi apparatus [UNKNOWN]
    plasma membrane [IDA]
    Biological Process: peptidyl-tyrosine phosphorylation [UNKNOWN][IDA]
    response to zinc ion [IEP]
    cellular zinc ion homeostasis [UNKNOWN]
    positive regulation of gamma-delta T cell differentiation [UNKNOWN][IEA]
    protein amino acid autophosphorylation [UNKNOWN][IDA]
    cell surface receptor linked signaling pathway [UNKNOWN][IEA]
    response to hydrogen peroxide [IDA]
    protein amino acid phosphorylation [UNKNOWN]
    aging [IEP]
    response to mechanical stimulus [IMP]
    T cell differentiation [UNKNOWN]
    positive regulation of T cell activation [UNKNOWN]
    positive regulation of uterine smooth muscle contraction [IMP]
    induction of apoptosis [UNKNOWN]
    response to drug [UNKNOWN]
    apoptosis [IEP]
    response to metal ion [IDA]
    regulation of T cell receptor signaling pathway [UNKNOWN][IEA]
    activation of caspase activity [UNKNOWN]
    release of sequestered calcium ion into cytosol [IEA]
    B cell receptor signaling pathway [UNKNOWN][IEA]
    Molecular Function: protein kinase binding [UNKNOWN]
    phosphoinositide 3-kinase binding [UNKNOWN]
    protein C-terminus binding [UNKNOWN]
    CD4 receptor binding [UNKNOWN]
    SH2 domain binding [UNKNOWN]
    CD8 receptor binding [UNKNOWN]
    nucleotide binding [IEA]
    protein serine/threonine phosphatase activity [UNKNOWN]
    ATP binding [IEA]
    protein tyrosine kinase activity [UNKNOWN][IDA]
    protein binding [UNKNOWN][IPI]
    non-membrane spanning protein tyrosine kinase activity [IEA]
    glycoprotein binding [UNKNOWN]
    transferase activity [IEA]
    protein complex binding [IDA]
    ATPase binding [UNKNOWN]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGCVCSSNPE DDWMENIDVC ENCHYPIVPL DSKSTLPIRT GSEVRDPLVT YEGSLPPASP  60
   61 LQDNLVIALH SYEPSHDGDL GFEKGEQLRI LEQSGEWWKA QSLTTGQEGF IPFNFVAKAN 120
  121 SLEPEPWFFK NLSRKDAERQ LLAPGNTHGS FLIRESESTA GSFSLSVRDF DQNQGEVVKH 180
  181 YKIRNLDNGG FYISPRITFP GLHDLVRHYT NASDGLCTKL SRPCQTQKPQ KPWWEDEWEV 240
  241 PRETLKLVER LGAGQFGEVW MGYYNGHTKV AVKSLKQGSM SPDAFLAEAN LMKQLQHPRL 300
  301 VRLYAVVTQE PIYIITEYME NGSLVDFLKT PSGIKLNVNK LLDMAAQIAE GMAFIEEQNY 360
  361 IHRDLRAANI LVSDTLSCKI ADFGLARLIE DNEYTAREGA KFPIKWTAPE AINYGTFTIK 420
  421 SDVWSFGILL TEIVTHGRIP YPGMTNPEVI QNLEKGYRMV RPDNCPEELY HLMMLCWKER 480
  481 PEDRPTFDYL RSVLDDFFTA TEGQYQPQP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle