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Protein Overview: Psi-PC

General Information:
Name(s) found: Psi-PC / FBpp0086222 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene P-element somatic inhibitor is referred to in FlyBase by the symbol Dmel\Psi (CG8912, FBgn0014870). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:12750470..12755218. It has the cytological map location 53D14. There is experimental evidence that it has the molecular function</span>: mRNA binding. There is experimental evidence that it is involved in the biological process</span>: mRNA processing; negative regulation of nuclear mRNA splicing, via spliceosome; regulation of nuclear mRNA splicing, via spliceosome; regulation of alternative nuclear mRNA splicing, via spliceosome; spermatogenesis. 12 alleles are reported. The phenotypes of these alleles are annotated with: onion stage spermatid; spermatid; testis. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 797 amino acids

    Gene Ontology:
    Cellular Component: U1 snRNP [IPI]
    Biological Process: regulation of alternative nuclear mRNA splicing, via spliceosome [IMP]
    negative regulation of nuclear mRNA splicing, via spliceosome [IDA][IMP]
    spermatogenesis [IMP]
    regulation of nuclear mRNA splicing, via spliceosome [IMP]
    mRNA processing [IDA]
    Molecular Function: mRNA binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDFQQQGIN QSQALAQAIQ RAKQIAAKIQ PSQQGGGTAG PSPPSSGGGP GFKRINDDGD  60
   61 SGPESKRSLG SPEYANNSSN MSSGSGGGGG GGGGPGGASI TQAIAQAAAV AARLAASAGT 120
  121 SCEEQIRLPE SVAGAFMGRS SNDTITHIQA ESGVKVQVMQ DQDRVIMLRG QRDTVTKGRE 180
  181 MIQNMANRAG GGQVEVLLTI NMPPPGPSGY PPYQEIMIPG AKVGLVIGKG GDTIKQLQEK 240
  241 TGAKMIIIQD GPNQELIKPL RISGEAQKIE HAKQMVLDLI AQKDAQGQQQ GGRGGGGGGG 300
  301 GPGMGFNNFN NGNGGESTEV FVPKIAVGVV IGKGGDMIRK IQTECGCKLQ FIQGKNDEMG 360
  361 DRRCVIQGTR QQVDDAKRTI DGLIENVMQR NGMNRNGNGG GGGPGGDSGN SNYGYGYGVN 420
  421 HAQGGREEIT FLVPASKCGI VIGRGGETIK LINQQSGAHT EMDRNASNPP NEKLFKSKGT 480
  481 TDQVEAARQM ISEKINMELN VISRKPIGGG PGGGGGNSGG GQNNSHHNQQ QGGYGGQNQM 540
  541 QGGDPNSGAG YQQQPWGGPY GQQGWDPSGQ QQQMAMANQG GSAAGGASGG QDYSAQWIEY 600
  601 YKQMGCHREA EMIEQQMKAK QAGGSSGPVQ QQQPQQQQQS QQQTGGAGAG GADYSAQWAE 660
  661 YYRSVGKIEE AEAIEKTLKN KQQNGSGGQS STPNPSQGGS GQQQPNPAAA AAAAAAAAAA 720
  721 AGGYGQSMTP TQYAQYSQYY AAAAAAGGQP QGAPQPGGGQ SGGPPGNYPG NYPGAGYGGY 780
  781 PGAPGQQQQK SHKNDNH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..112] deduced N/A No confident structure predictions are available.
    2 View Details [113..296] PSI-BLAST 27.522879 No description for 2annA was found.
    3 View Details [297..502] PSI-BLAST 19.0 Far upstream binding element, FBP, KH3 and KH4 domains
    4 View Details [503..615] deduced N/A No confident structure predictions are available.
    5 View Details [616..797] PSI-BLAST 7.0 Sec24

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • RNA binding
    		•  6.76415077523249 bayes_pls_golite062009
  • mRNA binding
    		•  5.07455187994216 bayes_pls_golite062009
    		• 4.82131641133915 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.78650555542715 bayes_pls_golite062009
  • binding
    		•  3.45962790790935 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.28364833275102 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  2.05765562493656 bayes_pls_golite062009
  • DNA binding
    		•  2.03207983673692 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.87340518658135 bayes_pls_golite062009
  • transcription factor activity
    		•  1.30278154718684 bayes_pls_golite062009
  • protein binding
    		•  1.16541072642796 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  0.981003625136521 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.489176583045793 bayes_pls_golite062009
  • transcription activator activity
    		•  0.324382863054631 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.32222928997178 bayes_pls_golite062009
  • transcription factor binding
    		•  0.254024117548226 bayes_pls_golite062009
  • catalytic activity
    		•  0.113112541746059 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.1069917291606 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.0321875054165348 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.78

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle