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Protein Overview: heph-PG

General Information:
Name(s) found: heph-PG / FBpp0085246 [FlyBase]
Description(s) found:
Found 18 descriptions.
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  • The gene hephaestus is referred to in FlyBase by the symbol Dmel\heph (CG31000, FBgn0011224). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:27676704..27819000. It has the cytological map location 100D3-100E1. Based on sequence similarity, it is predicted to have molecular function</span>: poly-pyrimidine tract binding; mRNA binding. There is experimental evidence that it is involved in the biological process</span>: spermatid development; imaginal disc-derived wing margin morphogenesis; imaginal disc-derived wing vein morphogenesis; Notch signaling pathway. 103 alleles are reported. The phenotypes of these alleles are annotated with: macrochaeta; testis; wing; individualization stage spermatid; spermatozoon. It has 22 annotated transcripts and 22 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 615 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA]
    ribonucleoprotein complex [IDA]
    cytoplasm [IDA]
    Biological Process: negative regulation of oskar mRNA translation [IMP]
    Notch signaling pathway [IMP]
    spermatid development [IMP]
    imaginal disc-derived wing margin morphogenesis [IMP]
    oocyte microtubule cytoskeleton polarization [IMP]
    imaginal disc-derived wing vein morphogenesis [IMP]
    nuclear mRNA splicing, via spliceosome [ISS]
    Molecular Function: nucleotide binding [IEA]
    poly-pyrimidine tract binding [ISS][NAS]
    translation repressor activity, nucleic acid binding [IMP]
    mRNA binding [ISS]
    mRNA 3'-UTR binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MREFVATMMS CPIPMPMPIS SLHKSEFEPV NIGVKRGSDE LLSQAAVMAP ASDNNNQDLA  60
   61 TKKAKLEPGT VLAGGIAKAS KVIHLRNIPN ESGEADVIAL GIPFGRVTNV LVLKGKNQAF 120
  121 IEMADEISAT SMVSCYTVTP PQMRGRMVYV QFSNHRELKT DQGHNNSTAH SDYSVQSPAS 180
  181 GSPLPLSAAA NATSNNANSS SDSNSAMGIL QNTSAVNAGG NTNAAGGPNT VLRVIVESLM 240
  241 YPVSLDILHQ IFQRYGKVLK IVTFTKNNSF QALIQYPDAN SAQHAKSLLD GQNIYNGCCT 300
  301 LRIDNSKLTA LNVKYNNDKS RDFTNPALPP GEPGVDIMPT AGGLMNTNDL LLIAARQRPS 360
  361 LSGDKIVNGL GAPGVLPPFA LGLGTPLTGG YNNALPNLAA FSLANSGALQ TTAPAMRGYS 420
  421 NVLLVSNLNE EMVTPDALFT LFGVYGDVQR VKILYNKKDS ALIQMAEPQQ AYLAMSHLDK 480
  481 LRLWGKPIRV MASKHQAVQL PKEGQPDAGL TRDYSQNPLH RFKKPGSKNY QNIYPPSATL 540
  541 HLSNIPSSCS EDDIKEAFTS NSFEVKAFKF FPKDRKMALL QLLSVEEAVL ALIKMHNHQL 600
  601 SESNHLRVSF SKSNI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..217] PSI-BLAST 16.154902 Solution structure of Polypyrimidine Tract Binding protein RBD1 complexed with CUCUCU RNA
    2 View Details [218..397] PSI-BLAST 12.221849 Solution structure of Polypyrimidine Tract Binding protein RBD2 complexed with CUCUCU RNA
    3 View Details [398..615] PSI-BLAST 44.0 Solution structure of Polypyrimidine Tract Binding protein RBD34 complexed with CUCUCU RNA

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • RNA binding
    		•  6.73097473547076 bayes_pls_golite062009
    		• 6.62953239642182 bayes_pls_golite062009
  • mRNA binding
    		•  5.29759606920196 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.81920018903278 bayes_pls_golite062009
  • binding
    		•  3.64400841800969 bayes_pls_golite062009
  • snRNA binding
    		•  3.28448936696877 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  3.11990160533699 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  2.93798024346416 bayes_pls_golite062009
  • U1 snRNA binding
    		•  2.26303528058407 bayes_pls_golite062009
  • structural molecule activity
    		•  1.29928829870122 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.23032741934624 bayes_pls_golite062009
  • protein binding
    		•  1.12215421354121 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.07788694919471 bayes_pls_golite062009
  • DNA binding
    		•  0.978604858165557 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.591700155096213 bayes_pls_golite062009
  • transcription factor activity
    		•  0.234742017105535 bayes_pls_golite062009
  • snoRNA binding
    		•  0.0568636182001701 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • RNA binding
    		•  6.73097473547076 bayes_pls_golite062009
    		• 6.62953239642182 bayes_pls_golite062009
  • mRNA binding
    		•  5.29759606920196 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.81920018903278 bayes_pls_golite062009
  • binding
    		•  3.64400841800969 bayes_pls_golite062009
  • snRNA binding
    		•  3.28448936696877 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  3.11990160533699 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  2.93798024346416 bayes_pls_golite062009
  • U1 snRNA binding
    		•  2.26303528058407 bayes_pls_golite062009
  • structural molecule activity
    		•  1.29928829870122 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.23032741934624 bayes_pls_golite062009
  • protein binding
    		•  1.12215421354121 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.07788694919471 bayes_pls_golite062009
  • DNA binding
    		•  0.978604858165557 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.591700155096213 bayes_pls_golite062009
  • transcription factor activity
    		•  0.234742017105535 bayes_pls_golite062009
  • snoRNA binding
    		•  0.0568636182001701 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.73

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle