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View Structure Prediction Details

Protein: heph-PG
Organism: Drosophila melanogaster
Length: 615 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for heph-PG.

Description E-value Query
Range
Subject
Range
gi|114674372 - gi|114674372|ref|XP_001172084.1| PREDICTED: polypyrimidine tract-binding protein 1 [Pan troglodytes]
330.0 [0..7] [615..349]

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Predicted Domain #1
Region A:
Residues: [1-217]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MREFVATMMS CPIPMPMPIS SLHKSEFEPV NIGVKRGSDE LLSQAAVMAP ASDNNNQDLA  60
   61 TKKAKLEPGT VLAGGIAKAS KVIHLRNIPN ESGEADVIAL GIPFGRVTNV LVLKGKNQAF 120
  121 IEMADEISAT SMVSCYTVTP PQMRGRMVYV QFSNHRELKT DQGHNNSTAH SDYSVQSPAS 180
  181 GSPLPLSAAA NATSNNANSS SDSNSAMGIL QNTSAVN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.154902
Match: 2ad9A
Description: Solution structure of Polypyrimidine Tract Binding protein RBD1 complexed with CUCUCU RNA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 6.73097473547076 bayes_pls_golite062009
6.62953239642182 bayes_pls_golite062009
mRNA binding 5.29759606920196 bayes_pls_golite062009
nucleic acid binding 3.81920018903278 bayes_pls_golite062009
binding 3.64400841800969 bayes_pls_golite062009
snRNA binding 3.28448936696877 bayes_pls_golite062009
poly-pyrimidine tract binding 3.11990160533699 bayes_pls_golite062009
single-stranded RNA binding 2.93798024346416 bayes_pls_golite062009
U1 snRNA binding 2.26303528058407 bayes_pls_golite062009
structural molecule activity 1.29928829870122 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.23032741934624 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
transcription regulator activity 1.07788694919471 bayes_pls_golite062009
DNA binding 0.978604858165557 bayes_pls_golite062009
mRNA 3'-UTR binding 0.591700155096213 bayes_pls_golite062009
transcription factor activity 0.234742017105535 bayes_pls_golite062009
snoRNA binding 0.0568636182001701 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [218-397]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AGGNTNAAGG PNTVLRVIVE SLMYPVSLDI LHQIFQRYGK VLKIVTFTKN NSFQALIQYP  60
   61 DANSAQHAKS LLDGQNIYNG CCTLRIDNSK LTALNVKYNN DKSRDFTNPA LPPGEPGVDI 120
  121 MPTAGGLMNT NDLLLIAARQ RPSLSGDKIV NGLGAPGVLP PFALGLGTPL TGGYNNALPN 180
  181 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.221849
Match: 2adbA
Description: Solution structure of Polypyrimidine Tract Binding protein RBD2 complexed with CUCUCU RNA
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [398-615]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LAAFSLANSG ALQTTAPAMR GYSNVLLVSN LNEEMVTPDA LFTLFGVYGD VQRVKILYNK  60
   61 KDSALIQMAE PQQAYLAMSH LDKLRLWGKP IRVMASKHQA VQLPKEGQPD AGLTRDYSQN 120
  121 PLHRFKKPGS KNYQNIYPPS ATLHLSNIPS SCSEDDIKEA FTSNSFEVKA FKFFPKDRKM 180
  181 ALLQLLSVEE AVLALIKMHN HQLSESNHLR VSFSKSNI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 44.0
Match: 2adcA
Description: Solution structure of Polypyrimidine Tract Binding protein RBD34 complexed with CUCUCU RNA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 6.73097473547076 bayes_pls_golite062009
6.62953239642182 bayes_pls_golite062009
mRNA binding 5.29759606920196 bayes_pls_golite062009
nucleic acid binding 3.81920018903278 bayes_pls_golite062009
binding 3.64400841800969 bayes_pls_golite062009
snRNA binding 3.28448936696877 bayes_pls_golite062009
poly-pyrimidine tract binding 3.11990160533699 bayes_pls_golite062009
single-stranded RNA binding 2.93798024346416 bayes_pls_golite062009
U1 snRNA binding 2.26303528058407 bayes_pls_golite062009
structural molecule activity 1.29928829870122 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.23032741934624 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
transcription regulator activity 1.07788694919471 bayes_pls_golite062009
DNA binding 0.978604858165557 bayes_pls_golite062009
mRNA 3'-UTR binding 0.591700155096213 bayes_pls_golite062009
transcription factor activity 0.234742017105535 bayes_pls_golite062009
snoRNA binding 0.0568636182001701 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle