Protein Overview: PKD-PB, PKD-PA, ...

General Information:
Name(s) found:	FBpp0303344 [FlyBase] PKD-PE / FBpp0288462 [FlyBase] PKD-PD / FBpp0083013 [FlyBase] PKD-PC / FBpp0083012 [FlyBase] PKD-PB / FBpp0083011 [FlyBase] PKD-PA / FBpp0083010 [FlyBase]
Description(s) found: Found 72 descriptions. SHOW ALL	type=protein; loc=3R:complement(14129588..14129784,14129854..14130591,14130650..14131631,14132341..14132525,14132600..14132737,14133179..14133323,14134704..14134829); ID=FBpp0303344; name=PKD-PF; parent=FBgn0038603,FBtr0330312; dbxref=FlyBase:FBpp0303344,FlyBase_Annotation_IDs:CG7125-PF,REFSEQ:NP_001262704,GB_protein:AGB96084; MD5=0d40bfba0145c6c037a594b19910a4c1; length=836; release=r5.56; species=Dmel; [FlyBase] The gene Protein Kinase D is referred to in FlyBase by the symbol Dmel\PKD (CG7125, FBgn0038603). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:14128998..14140129. It has the cytological map location 91A2. Based on sequence similarity, it is predicted to have molecular function</span>: diacylglycerol binding; protein serine/threonine kinase activity. It is reported to be involved in the biological process</span>: protein amino acid phosphorylation. 5 alleles are reported. No phenotypic data is available. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase] The gene Protein Kinase D is referred to in FlyBase by the symbol Dmel\PKD (CG7125, FBgn0038603). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:14128998..14140129. It has the cytological map location 91A2. Based on sequence similarity, it is predicted to have molecular function</span>: diacylglycerol binding; protein serine/threonine kinase activity. It is reported to be involved in the biological process</span>: protein amino acid phosphorylation. 5 alleles are reported. No phenotypic data is available. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase] The gene Protein Kinase D is referred to in FlyBase by the symbol Dmel\PKD (CG7125, FBgn0038603). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:14128998..14140129. It has the cytological map location 91A2. Based on sequence similarity, it is predicted to have molecular function</span>: diacylglycerol binding; protein serine/threonine kinase activity. It is reported to be involved in the biological process</span>: protein amino acid phosphorylation. 5 alleles are reported. No phenotypic data is available. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase] The gene Protein Kinase D is referred to in FlyBase by the symbol Dmel\PKD (CG7125, FBgn0038603). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:14128998..14140129. It has the cytological map location 91A2. Based on sequence similarity, it is predicted to have molecular function</span>: diacylglycerol binding; protein serine/threonine kinase activity. It is reported to be involved in the biological process</span>: protein amino acid phosphorylation. 5 alleles are reported. No phenotypic data is available. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase] The gene Protein Kinase D is referred to in FlyBase by the symbol Dmel\PKD (CG7125, FBgn0038603). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:14128998..14140129. It has the cytological map location 91A2. Based on sequence similarity, it is predicted to have molecular function</span>: diacylglycerol binding; protein serine/threonine kinase activity. It is reported to be involved in the biological process</span>: protein amino acid phosphorylation. 5 alleles are reported. No phenotypic data is available. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	836 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA]
Biological Process:	intracellular signaling pathway [IEA] protein amino acid phosphorylation [IEA][NAS]
Molecular Function:	ATP binding [IEA] diacylglycerol binding [ISS] protein serine/threonine kinase activity [ISS][NAS] protein kinase C activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEGPEVTFLF QFGSVRDAVC VPANSLTLKT LKDLACDFIN TKIPDSGLTY LSERILLFVH  60
   61 DYSTPNVLHI INSAAEVVDE TLVEIVLTAS PILYPTSEMP TLKPHSLNVH SYKGPTFCDF 120
  121 CGEMLFGLVR QGLKCDGCGQ NYHKRCVVKI PNNCNRSNDA TSRRSFTLQA PRSPSGSSQQ 180
  181 SLVSTEDSTG RNDSSSSLNI PGRHQRTHSS GSRNGLMVLR IPHTFMVHTY GIPTVCQLCK 240
  241 KLLKGLFKQG LQCRDCQYNT HKKCMDKVPH DCTGEAQLSQ LQIQAGAKER DNFFREEFDD 300
  301 SDGDDGSEYG KYKSAMSSGV NLVAGRPREA PKALTNAHNS PPELVNGGLV DDSSVSGGET 360
  361 SKSSSDGQSE QSQSSTSSSP SANIPLMRIV QSVKHTKKRG GQALKEGWLV HYTSLDKAVK 420
  421 RYYWRLDSKT ITLFVSEQGS KYHKELPLAE LLSIESHLGD PRPECNYCFE LRLPNLSYFV 480
  481 GQDPQVGAKE EQAVRLPPPD SGIGSDIAKS WETSIRQAFM HVTNTQCCES EEQVQDMGQL 540
  541 YQIFPDEVLG SGQFGVVYGG VHKKTQREVA IKVIDKLRFP TKQEAQLKNE VAILQNISHC 600
  601 GVVNLERMFE TPERIFVVME KLKGDMLEMI LSHARGRLSE RVTKFLITQI LIALKYLHSQ 660
  661 NIVHCDLKPE NVLLSSDAEF PQVKLCDFGY ARIIGEKSFR RSVVGTPAYL APEVLRNKGY 720
  721 NRSLDMWSVG VIIYVSLSGT FPFNEEEDIN DQIQNAAFMY PPNPWKEISS NAIDLINNLL 780
  781 QVKQRKRYTV DKSLLHYWLQ DKQTYRDLRN LEAQVGAGRY LTHEADDLRW DCAGDM

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
binding	2.28355670417117	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	2.07238897772131	bayes_pls_golite062009
kinase activity	2.00903309297046	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.83466699022067	bayes_pls_golite062009
protein kinase activity	1.79721531351546	bayes_pls_golite062009
signal transducer activity	1.70194421865269	bayes_pls_golite062009
molecular transducer activity	1.70194421865269	bayes_pls_golite062009
transferase activity	1.45394179515146	bayes_pls_golite062009
protein binding	1.21002143294224	bayes_pls_golite062009
GTPase regulator activity	1.12412426198961	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	1.10707685935826	bayes_pls_golite062009
protein serine/threonine kinase activity	0.93378879973188	bayes_pls_golite062009
enzyme regulator activity	0.717794523788476	bayes_pls_golite062009
guanyl-nucleotide exchange factor activity	0.6091533221871	bayes_pls_golite062009
small GTPase regulator activity	0.442062495186646	bayes_pls_golite062009
transcription regulator activity	0.302160974118897	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.288015740129042	bayes_pls_golite062009
catalytic activity	0.216721136299042	bayes_pls_golite062009

Term	Confidence	Notes
binding	2.36195429973813	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	2.10625597744594	bayes_pls_golite062009
kinase activity	2.03632850156074	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.8531437045627	bayes_pls_golite062009
protein kinase activity	1.80739081420522	bayes_pls_golite062009
signal transducer activity	1.70650638346167	bayes_pls_golite062009
molecular transducer activity	1.70650638346167	bayes_pls_golite062009
transferase activity	1.4550521488922	bayes_pls_golite062009
GTPase regulator activity	1.39167263636091	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	1.37139209958305	bayes_pls_golite062009
protein binding	1.29100556128076	bayes_pls_golite062009
protein serine/threonine kinase activity	0.956859696337723	bayes_pls_golite062009
enzyme regulator activity	0.911061212692491	bayes_pls_golite062009
guanyl-nucleotide exchange factor activity	0.907368864863833	bayes_pls_golite062009
small GTPase regulator activity	0.661240850692236	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.53849800215034	bayes_pls_golite062009
transcription regulator activity	0.348246993470003	bayes_pls_golite062009
catalytic activity	0.194464246602439	bayes_pls_golite062009

Term	Confidence	Notes
cytoskeletal protein binding	3.36168834560682	bayes_pls_golite062009
actin binding	3.02207723543271	bayes_pls_golite062009
binding	2.73312450062269	bayes_pls_golite062009
molecular transducer activity	1.97025592796299	bayes_pls_golite062009
signal transducer activity	1.97025592796299	bayes_pls_golite062009
protein binding	1.95763087285706	bayes_pls_golite062009
phosphoinositide 3-kinase binding	1.71957805451003	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.55414958698765	bayes_pls_golite062009
protein kinase activity	1.53914015577029	bayes_pls_golite062009
kinase activity	1.52393509273639	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.39413069155432	bayes_pls_golite062009
actin filament binding	1.36137023741209	bayes_pls_golite062009
transferase activity	1.09391396934652	bayes_pls_golite062009
receptor activity	0.931224448280242	bayes_pls_golite062009
transporter activity	0.891689255086028	bayes_pls_golite062009
receptor signaling protein activity	0.830314446783898	bayes_pls_golite062009
transmembrane receptor activity	0.816556845126609	bayes_pls_golite062009
chromatin binding	0.797544081438342	bayes_pls_golite062009
protein domain specific binding	0.650240628628722	bayes_pls_golite062009
protein serine/threonine kinase activity	0.62326150960884	bayes_pls_golite062009
substrate-specific transporter activity	0.487385951045272	bayes_pls_golite062009
receptor binding	0.391425518916624	bayes_pls_golite062009
structural molecule activity	0.332112521019418	bayes_pls_golite062009
structural constituent of cytoskeleton	0.328898130778985	bayes_pls_golite062009
GTPase regulator activity	0.191468082618045	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	0.174772802535455	bayes_pls_golite062009
enzyme regulator activity	0.0687306550834211	bayes_pls_golite062009

No functions predicted.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..62]	deduced	N/A	No confident structure predictions are available.
2	View Details	[63..167]	FFAS03	3.01	Solution Structure of The C1 Domain of The Human Diacylglycerol Kinase Delta
3	View Details	[168..285]	PSI-BLAST	18.0	Crystal Structure of the Human Beta2-Chimaerin
4	View Details	[286..496]	FFAS03	4.86	Crystal Structure of a N-terminal Fragment of SKAP-Hom Containing Both the Helical Dimerization Domain and the PH Domain
5	View Details	[497..836]	PSI-BLAST	81.30103	No description for 2gnfA was found.

Protein Overview: PKD-PB, PKD-PA, ...

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: