Protein Overview: FBpp0310357, gfA...

General Information:
Name(s) found:	FBpp0310357 [FlyBase] gfA-PD / FBpp0291048 [FlyBase] gfA-PA / FBpp0089248 [FlyBase]
Description(s) found: Found 28 descriptions. SHOW ALL	type=protein; loc=X:complement(19223745..19223753,19223823..19223966,19224134..19224287,19225285..19225401,19225521..19225675,19228448..19228557,19234536..19234622,19235879..19236073,19236315..19236390,19236452..19236632,19236761..19236870,19236933..19236977,19237151..19237290,19237530..19237689); ID=FBpp0310357; name=nAChRalpha7-PF; parent=FBgn0086778,FBtr0343798; dbxref=FlyBase:FBpp0310357,FlyBase_Annotation_IDs:CG32538-PF; MD5=9db9eebca3925a1034d59a2437a4270f; length=560; release=r5.56; species=Dmel; [FlyBase] The gene giant fibre A is referred to in FlyBase by the symbol Dmel\gfA (CG32538, FBgn0086778). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:19222594..19242477. It has the cytological map location 18C2-18C3. Based on sequence similarity, it is predicted to have molecular function</span>: nicotinic acetylcholine-activated cation-selective channel activity. There is experimental evidence that it is involved in the biological process</span>: synaptic transmission; regulation of excitatory postsynaptic membrane potential; visual behavior; jump response. 23 alleles are reported. The phenotype of these alleles is annotated with: giant fibers. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase] The gene giant fibre A is referred to in FlyBase by the symbol Dmel\gfA (CG32538, FBgn0086778). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:19222594..19242477. It has the cytological map location 18C2-18C3. Based on sequence similarity, it is predicted to have molecular function</span>: nicotinic acetylcholine-activated cation-selective channel activity. There is experimental evidence that it is involved in the biological process</span>: synaptic transmission; regulation of excitatory postsynaptic membrane potential; visual behavior; jump response. 23 alleles are reported. The phenotype of these alleles is annotated with: giant fibers. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	560 amino acids
Gene Ontology:
Cellular Component:	dendrite [IDA] postsynaptic membrane [IEA] dendritic spine [IDA] integral to membrane [IEA] nicotinic acetylcholine-gated receptor-channel complex [ISS][NAS]
Biological Process:	ion transport [IEA] regulation of excitatory postsynaptic membrane potential [IMP] jump response [IMP] synaptic transmission [IMP] visual behavior [IMP]
Molecular Function:	nicotinic acetylcholine-activated cation-selective channel activity [ISS][NAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKPSRSRPD NPSCPGQDRT RSMSFPQPHS LPEATANGGR MLVYGLGLLI MIPACAAGPH  60
   61 EKRLLHALLD NYNSLERPVV NESDPLQLSF GLTLMQIIDV DEKNQLLITN IWLKLEWNDM 120
  121 NLRWNSSEFG GVRDLRIPPH RLWKPDVLMY NSADEGFDGT YATNVVVRNN GSCLYVPPGI 180
  181 FKSTCKIDIT WFPFDDQRCE MKFGSWTYDG FQLDLQLQDE AGGDISSFIT NGEWDLLGVP 240
  241 GKRNEIYYNC CPEPYIDITF AILIRRKTLY YFFNLIVPCV LIASMALLGF TLPPDSGEKL 300
  301 SLGVTILLSL TVFLNMVAET MPATSDAVPL LGTYFNCIMF MVASSVVSTI LILNYHHRNP 360
  361 DTHEMSEWIR VIFLYWLPCI LRMQRPGQVG YECPPPPSSS SSSASGEKKQ QIQNVELKER 420
  421 SSKSLLANVL DIDDDFRCNH RCASATLPHQ PTYYRTMYRQ GDDGSVGPVG PAGPVVDGRL 480
  481 HEAISHTCLT SSAEYELALI LKELRWITEQ LKKEDETSDI TRDWKFAAMV VDRLCLIIFT 540
  541 LFTIIATLAV LFSAPHFIFP

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
acetylcholine binding	13.9752632471881	bayes_pls_golite062009
acetylcholine receptor activity	13.7533645836795	bayes_pls_golite062009
nicotinic acetylcholine-activated cation-selective channel activity	13.1511875247796	bayes_pls_golite062009
metal ion transmembrane transporter activity	11.9525876011069	bayes_pls_golite062009
extracellular ligand-gated ion channel activity	11.7813202122163	bayes_pls_golite062009
excitatory extracellular ligand-gated ion channel activity	11.7813202122163	bayes_pls_golite062009
cation channel activity	11.7442066737514	bayes_pls_golite062009
ion channel activity	11.1753684044644	bayes_pls_golite062009
passive transmembrane transporter activity	11.0903806681397	bayes_pls_golite062009
channel activity	11.0903806681397	bayes_pls_golite062009
gated channel activity	11.0397691626728	bayes_pls_golite062009
substrate-specific channel activity	10.9375522860542	bayes_pls_golite062009
ligand-gated channel activity	9.34902726749692	bayes_pls_golite062009
ligand-gated ion channel activity	9.34902726749692	bayes_pls_golite062009
amine binding	9.11982124959723	bayes_pls_golite062009
chloride channel regulator activity	9.10587892909341	bayes_pls_golite062009
ion transmembrane transporter activity	7.22265353460749	bayes_pls_golite062009
cation transmembrane transporter activity	7.19173677417054	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	6.7875346065164	bayes_pls_golite062009
transmembrane receptor activity	5.4080353535498	bayes_pls_golite062009
receptor activity	5.11329651194787	bayes_pls_golite062009
transporter activity	5.11262082564788	bayes_pls_golite062009
transmembrane transporter activity	5.03439798256257	bayes_pls_golite062009
substrate-specific transporter activity	4.91314874981447	bayes_pls_golite062009
neurotransmitter binding	4.25797760547212	bayes_pls_golite062009
neurotransmitter receptor activity	4.15404686068319	bayes_pls_golite062009
signal transducer activity	4.12549692767753	bayes_pls_golite062009
molecular transducer activity	4.12549692767753	bayes_pls_golite062009
binding	2.4916526322278	bayes_pls_golite062009
adenylate cyclase binding	2.44136378171826	bayes_pls_golite062009
beta-amyloid binding	2.25766805801029	bayes_pls_golite062009
	1.68370717591127	bayes_pls_golite062009
channel regulator activity	1.66978990310631	bayes_pls_golite062009
protein binding	1.45740893920165	bayes_pls_golite062009
G-protein coupled receptor activity	1.42422063123689	bayes_pls_golite062009
serotonin binding	1.33584589886834	bayes_pls_golite062009
serotonin-activated cation-selective channel activity	1.31324203158511	bayes_pls_golite062009
toxin binding	1.03329843925063	bayes_pls_golite062009
drug binding	0.64715018605883	bayes_pls_golite062009
kinase binding	0.365355763029699	bayes_pls_golite062009
protein kinase binding	0.350601457777817	bayes_pls_golite062009

Source: Reynolds et al. 2008. Manuscript submitted

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..365]	PSI-BLAST	83.39794	Refined structure of the nicotinic acetylcholine receptor at 4A resolution.
2	View Details	[366..560]	PSI-BLAST	44.30103	Acetylcholine receptor protein, beta chain

Protein Overview: FBpp0310357, gfA...

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: