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Protein Overview: Nmdar2-PA, Nmdar...

General Information:
Name(s) found: Nmdar2-PD / FBpp0291056 [FlyBase]
Nmdar2-PB / FBpp0089173 [FlyBase]
Nmdar2-PA / FBpp0089172 [FlyBase]
Description(s) found:
Found 50 descriptions.
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  • The gene NMDA receptor 2 is referred to in FlyBase by the symbol Dmel\Nmdar2 (CG33513, FBgn0053513). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:1380259..1401842. It has the cytological map location 2B1. Based on sequence similarity, it is predicted to have molecular function</span>: N-methyl-D-aspartate selective glutamate receptor activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: ion transport. 5 alleles are reported. No phenotypic data is available. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
  • The gene NMDA receptor 2 is referred to in FlyBase by the symbol Dmel\Nmdar2 (CG33513, FBgn0053513). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:1380259..1401842. It has the cytological map location 2B1. Based on sequence similarity, it is predicted to have molecular function</span>: N-methyl-D-aspartate selective glutamate receptor activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: ion transport. 5 alleles are reported. No phenotypic data is available. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
  • The gene NMDA receptor 2 is referred to in FlyBase by the symbol Dmel\Nmdar2 (CG33513, FBgn0053513). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:1380259..1401842. It has the cytological map location 2B1. Based on sequence similarity, it is predicted to have molecular function</span>: N-methyl-D-aspartate selective glutamate receptor activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: ion transport. 5 alleles are reported. No phenotypic data is available. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 902 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEA]
    outer membrane-bounded periplasmic space [IEA]
    Biological Process: ion transport [IEA]
    Molecular Function: extracellular-glutamate-gated ion channel activity [IEA]
    ionotropic glutamate receptor activity [IEA]
    N-methyl-D-aspartate selective glutamate receptor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMNNEQFGHS TASAQYFLQL AGYLGIPVIS WNADNSGLER RASQSTLQLQ LAPSIEHQSA  60
   61 AMLSILERYK WHQFSVVTSQ IAGHDDFVQA VRERVAEMQE HFKFTILNSI VVTRTSDLME 120
  121 LVNSEARVML LYATQTEAIT ILRAAEEMKL TGENYVWVVS QSVIEKKDAH SQFPVGMLGV 180
  181 HFDTSSAALM NEISNAIKIY SYGVEAYLTD PANRDRRLTT QSLSCEDEGR GRWDNGEIFF 240
  241 KYLRNVSIEG DLNKPNIEFT ADGDLRSAEL KIMNLRPSAN NKNLVWEEIG VWKSWETQKL 300
  301 DIRDIAWPGN SHAPPQGVPE KFHLKITFLE EAPYINLSPA DPVSGKCLMD RGVLCRVAAD 360
  361 HEMAADIDVG QAHRNESFYQ CCSGFCIDLL EKFAEELGFT YELVRVEDGK WGTLENGKWN 420
  421 GLIADLVNRK TDMVLTSLMI NTEREAVVDF SEPFMETGIA IVVAKRTGII SPTAFLEPFD 480
  481 TASWMLVGIV AIQAATFMIF LFEWLSPSGY DMKLYLQNTN VTPYRFSLFR TYWLVWAVLF 540
  541 QAAVHVDSPR GFTSRFMTNV WALFAVVFLA IYTANLAAFM ITREEFHEFS GLNDSRLVHP 600
  601 FSHKPSFKFG TIPYSHTDST IHKYFNVMHN YMRQYNKTSV ADGVAAVLNG NLDSFIYDGT 660
  661 VLDYLVAQDE DCRLMTVGSW YAMTGYGLAF SRNSKYVQMF NKRLLEFRAN GDLERLRRYW 720
  721 MTGTCRPGKQ EHKSSDPLAL EQFLSAFLLL MAGILLAALL LLLEHVYFKY IRKRLAKKDG 780
  781 GHCCALISLS MGKSLTFRGA VFEATEILKK HRCNDPICDT HLWKVKHELD MSRLRVRQLE 840
  841 KVMDKHGIKA PQLRLASSSD LLNHHHLKER PPLLGNLSLA ASAQDLYRWS YKTEIAEMET 900
  901 VL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..440] PSI-BLAST 37.69897 No description for 2e4uA was found.
    2 View Details [441..506] FFAS03 2.8 Glutamine-binding protein
    3 View Details [507..723] PSI-BLAST 22.221849 Crystal Structure Of The NR2A Ligand Binding Core In Complex With Glutamate
    4 View Details [724..809] MSA 1.387993 View MSA. No confident structure predictions are available.
    5 View Details [810..902] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • amine binding
    		•  4.11747486942823 bayes_pls_golite062009
  • transporter activity
    		•  3.92658561501282 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.71430307970333 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.34421502810243 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  3.33883206510679 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  3.33572158012752 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  3.31947078781945 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  3.3164655425684 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  3.3159417475856 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  3.25041295044206 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.76254706952599 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.65558937563899 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.36995601057551 bayes_pls_golite062009
  • ATPase activity
    		•  2.35388655037218 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.29319753274625 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.27317031628667 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.27090852909065 bayes_pls_golite062009
  • peptide binding
    		•  2.13614935733644 bayes_pls_golite062009
  • binding
    		•  1.99193554770277 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  1.84929214408108 bayes_pls_golite062009
  • receptor activity
    		•  1.74349172783363 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.44487216360172 bayes_pls_golite062009
  • signal transducer activity
    		•  1.44487216360172 bayes_pls_golite062009
  • hydrolase activity
    		•  0.999095648881488 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions
    		•  0.88623763826001 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.810341130332095 bayes_pls_golite062009
  • protein binding
    		•  0.782435650956845 bayes_pls_golite062009
  • anion transmembrane transporter activity
    		•  0.75669016367838 bayes_pls_golite062009
  • catalytic activity
    		•  0.674312982669564 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  0.644907195402529 bayes_pls_golite062009
  • transcription factor activity
    		•  0.612192824804611 bayes_pls_golite062009
  • DNA binding
    		•  0.596947798194569 bayes_pls_golite062009
  • inorganic anion transmembrane transporter activity
    		•  0.555351218220589 bayes_pls_golite062009
  • amine transmembrane transporter activity
    		•  0.372828805396439 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.367839087542125 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.343508026849565 bayes_pls_golite062009
  • anion transmembrane-transporting ATPase activity
    		•  0.149393758153546 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle