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Protein Overview: gi|167887660, gi...

General Information:
Name(s) found: gi|32455244 [NCBI NR]
gi|20381187 [NCBI NR]
gi|167887660 [NCBI NR]
gi|119587555 [NCBI NR]
Description(s) found:
Found 26 descriptions.
SHOW ALL
  • gi|32455244|ref|NP_859050.1| beta isoform of regulatory subunit A, protein phosphatase 2 isoform b [Homo sapiens] [NCBI NR]
  • gi|20381187|gb|AAH27596.1| Protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform [Homo sapiens] [NCBI NR]
  • gi|167887660|gb|ACA06047.1| serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform variant 1 [Homo sapiens] [NCBI NR]
  • gi|119587555|gb|EAW67151.1| protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform, isoform CRA_b [Homo sapiens] [NCBI NR]
    • Organism: Homo sapiens
    Length: 667 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGASELGTG PGAAGGDGDD SLYPIAVLID ELRNEDVQLR LNSIKKLSTI ALALGVERTR  60
   61 SELLPFLTDT IYDEDEVLLA LAEQLGNFTG LVGGPDFAHC LLPPLENLAT VEETVVRDKA 120
  121 VESLRQISQE HTPVALEAYF VPLVKRLASG DWFTSRTSAC GLFSVCYPRA SNAVKAEIRQ 180
  181 QFRSLCSDDT PMVRRAAASK LGEFAKVLEL DSVKSEIVPL FTSLASDEQD SVRLLAVEAC 240
  241 VSIAQLLSQD DLETLVMPTL RQAAEDKSWR VRYMVADRFS ELQKAMGPKI TLNDLIPAFQ 300
  301 NLLKDCEAEV RAAAAHKVKE LGENLPIEDR ETIIMNQILP YIKELVSDTN QHVKSALASV 360
  361 IMGLSTILGK ENTIEHLLPL FLAQLKDECP DVRLNIISNL DCVNEVIGIR QLSQSLLPAI 420
  421 VELAEDAKWR VRLAIIEYMP LLAGQLGVEF FDEKLNSLCM AWLVDHVYAI REAATNNLMK 480
  481 LVQKFGTEWA QNTIVPKVLV MANDPNYLHR MTTLFCINAL SEACGQEITT KQMLPIVLKM 540
  541 AGDQVANVRF NVAKSLQKIG PILDTNALQG EVKPVLQKLG QDEDMDVKYF AQEAISVVAQ 600
  601 RLRKLEFPVK DSGEPSVPRA DKNHFPRPTV PGEDMGKGPV YQLRGDTRDT LAQLGIAELV 660
  661 HFSQSTD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MIS12 No Comments Cheeseman, I.M., et al. (2004)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..606] PSI-BLAST 78.69897 Constant regulatory domain of protein phosphatase 2a, pr65alpha
    2 View Details [607..667] PSI-BLAST 33.39794 Crystal structure of the exportin Cse1p complexed with its cargo ( Kap60p) and RanGTP

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  7.41566231556356 bayes_pls_golite062009
  • phosphatase activity
    		•  6.2815295903206 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  6.23975872771765 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  6.04343158483355 bayes_pls_golite062009
  • protein phosphatase type 2A regulator activity
    		•  5.96826345560807 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  5.13001603767079 bayes_pls_golite062009
  • binding
    		•  3.0667965351474 bayes_pls_golite062009
  • protein binding
    		•  2.78733902345842 bayes_pls_golite062009
  • phosphatase regulator activity
    		•  2.6399267580941 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.61566088685247 bayes_pls_golite062009
  • protein phosphatase regulator activity
    		•  2.60055057218296 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.44247330635325 bayes_pls_golite062009
  • actin binding
    		•  2.3058296268212 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.16673352512615 bayes_pls_golite062009
  • hydrolase activity
    		•  1.97016752220053 bayes_pls_golite062009
  • DNA binding
    		•  1.95242774903625 bayes_pls_golite062009
  • RNA binding
    		•  1.93705682476038 bayes_pls_golite062009
  • structural molecule activity
    		•  1.66077840765881 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.62227684952907 bayes_pls_golite062009
  • kinase activity
    		•  1.60994283310715 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.50380925936701 bayes_pls_golite062009
  • protein kinase activity
    		•  1.39674032951965 bayes_pls_golite062009
  • transferase activity
    		•  1.25186057612742 bayes_pls_golite062009
  • mRNA binding
    		•  1.24336280073688 bayes_pls_golite062009
  • transcription factor activity
    		•  1.20660383756339 bayes_pls_golite062009
  • myosin phosphatase activity
    		•  0.963950527497681 bayes_pls_golite062009
  • RNA cap binding
    		•  0.85857824809712 bayes_pls_golite062009
  • cadherin binding
    		•  0.83615873409529 bayes_pls_golite062009
  • translation initiation factor activity
    		•  0.83079633551839 bayes_pls_golite062009
  • translation regulator activity
    		•  0.82193201542158 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.803700928110921 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  0.65899395557033 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.638990331710836 bayes_pls_golite062009
  • signal transducer activity
    		•  0.611492201912646 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.611492201912646 bayes_pls_golite062009
  • protein phosphatase binding
    		•  0.21324446893915 bayes_pls_golite062009
  • transcription activator activity
    		•  0.160275383613705 bayes_pls_golite062009
  • phosphatase binding
    		•  0.12473988003504 bayes_pls_golite062009
  • transcription factor binding
    		•  0.0221966060394205 bayes_pls_golite062009
    2
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  7.41566231556356 bayes_pls_golite062009
  • phosphatase activity
    		•  6.2815295903206 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  6.23975872771765 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  6.04343158483355 bayes_pls_golite062009
  • protein phosphatase type 2A regulator activity
    		•  5.96826345560807 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  5.13001603767079 bayes_pls_golite062009
  • binding
    		•  3.0667965351474 bayes_pls_golite062009
  • protein binding
    		•  2.78733902345842 bayes_pls_golite062009
  • phosphatase regulator activity
    		•  2.6399267580941 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.61566088685247 bayes_pls_golite062009
  • protein phosphatase regulator activity
    		•  2.60055057218296 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.44247330635325 bayes_pls_golite062009
  • actin binding
    		•  2.3058296268212 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.16673352512615 bayes_pls_golite062009
  • hydrolase activity
    		•  1.97016752220053 bayes_pls_golite062009
  • DNA binding
    		•  1.95242774903625 bayes_pls_golite062009
  • RNA binding
    		•  1.93705682476038 bayes_pls_golite062009
  • structural molecule activity
    		•  1.66077840765881 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.62227684952907 bayes_pls_golite062009
  • kinase activity
    		•  1.60994283310715 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.50380925936701 bayes_pls_golite062009
  • protein kinase activity
    		•  1.39674032951965 bayes_pls_golite062009
  • transferase activity
    		•  1.25186057612742 bayes_pls_golite062009
  • mRNA binding
    		•  1.24336280073688 bayes_pls_golite062009
  • transcription factor activity
    		•  1.20660383756339 bayes_pls_golite062009
  • myosin phosphatase activity
    		•  0.963950527497681 bayes_pls_golite062009
  • RNA cap binding
    		•  0.85857824809712 bayes_pls_golite062009
  • cadherin binding
    		•  0.83615873409529 bayes_pls_golite062009
  • translation initiation factor activity
    		•  0.83079633551839 bayes_pls_golite062009
  • translation regulator activity
    		•  0.82193201542158 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.803700928110921 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  0.65899395557033 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.638990331710836 bayes_pls_golite062009
  • signal transducer activity
    		•  0.611492201912646 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.611492201912646 bayes_pls_golite062009
  • protein phosphatase binding
    		•  0.21324446893915 bayes_pls_golite062009
  • transcription activator activity
    		•  0.160275383613705 bayes_pls_golite062009
  • phosphatase binding
    		•  0.12473988003504 bayes_pls_golite062009
  • transcription factor binding
    		•  0.0221966060394205 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle