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View Structure Prediction Details

Protein: gi|167887660, gi...
Organism: Homo sapiens
Length: 667 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|167887660, gi....

Description E-value Query
Range		 Subject
Range
gi|26345996 - gi|26345996|dbj|BAC36649.1| unnamed protein product [Mus musculus]
 1.0E-87 [1..667] [1..694]
gi|73954805 - gi|73954805|ref|XP_850884.1| PREDICTED: similar to beta isoform of regulatory subunit A, protein pho...
 9.0E-84 [21..644] [21..644]
2AAB_RAT - Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform OS=Rattus norvegicu...
 2.0E-82 [1..599] [1..599]
2AAB_PIG - Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (Fragment) OS=Sus s...
gi|108376 - pir||D34541 phosphoprotein phosphatase (EC 3.1.3.16) 2A-beta 65K regulatory chain - pig (fragment)
 1.0E-80 [2..599] [3..600]
gi|28422226 - gi|28422226|gb|AAH44120.1| LOC398563 protein [Xenopus laevis]
 5.0E-78 [13..599] [5..591]
gi|168277686 - gi|168277686|dbj|BAG10821.1| serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A bet...
PPP2R1B - protein phosphatase 2, regulatory subunit A, beta
 7.0E-78 [1..599] [1..599]

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Predicted Domain #1
Region A:
Residues: [1-606] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGASELGTG PGAAGGDGDD SLYPIAVLID ELRNEDVQLR LNSIKKLSTI ALALGVERTR  60
   61 SELLPFLTDT IYDEDEVLLA LAEQLGNFTG LVGGPDFAHC LLPPLENLAT VEETVVRDKA 120
  121 VESLRQISQE HTPVALEAYF VPLVKRLASG DWFTSRTSAC GLFSVCYPRA SNAVKAEIRQ 180
  181 QFRSLCSDDT PMVRRAAASK LGEFAKVLEL DSVKSEIVPL FTSLASDEQD SVRLLAVEAC 240
  241 VSIAQLLSQD DLETLVMPTL RQAAEDKSWR VRYMVADRFS ELQKAMGPKI TLNDLIPAFQ 300
  301 NLLKDCEAEV RAAAAHKVKE LGENLPIEDR ETIIMNQILP YIKELVSDTN QHVKSALASV 360
  361 IMGLSTILGK ENTIEHLLPL FLAQLKDECP DVRLNIISNL DCVNEVIGIR QLSQSLLPAI 420
  421 VELAEDAKWR VRLAIIEYMP LLAGQLGVEF FDEKLNSLCM AWLVDHVYAI REAATNNLMK 480
  481 LVQKFGTEWA QNTIVPKVLV MANDPNYLHR MTTLFCINAL SEACGQEITT KQMLPIVLKM 540
  541 AGDQVANVRF NVAKSLQKIG PILDTNALQG EVKPVLQKLG QDEDMDVKYF AQEAISVVAQ 600
  601 RLRKLE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 78.69897
Match: 1b3uA
Description: Constant regulatory domain of protein phosphatase 2a, pr65alpha
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphoprotein phosphatase activity 7.41566231556356 bayes_pls_golite062009
phosphatase activity 6.2815295903206 bayes_pls_golite062009
protein serine/threonine phosphatase activity 6.23975872771765 bayes_pls_golite062009
phosphoric ester hydrolase activity 6.04343158483355 bayes_pls_golite062009
protein phosphatase type 2A regulator activity 5.96826345560807 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 5.13001603767079 bayes_pls_golite062009
binding 3.0667965351474 bayes_pls_golite062009
protein binding 2.78733902345842 bayes_pls_golite062009
phosphatase regulator activity 2.6399267580941 bayes_pls_golite062009
cytoskeletal protein binding 2.61566088685247 bayes_pls_golite062009
protein phosphatase regulator activity 2.60055057218296 bayes_pls_golite062009
nucleic acid binding 2.44247330635325 bayes_pls_golite062009
actin binding 2.3058296268212 bayes_pls_golite062009
transcription regulator activity 2.16673352512615 bayes_pls_golite062009
hydrolase activity 1.97016752220053 bayes_pls_golite062009
DNA binding 1.95242774903625 bayes_pls_golite062009
RNA binding 1.93705682476038 bayes_pls_golite062009
structural molecule activity 1.66077840765881 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.62227684952907 bayes_pls_golite062009
kinase activity 1.60994283310715 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.50380925936701 bayes_pls_golite062009
protein kinase activity 1.39674032951965 bayes_pls_golite062009
transferase activity 1.25186057612742 bayes_pls_golite062009
mRNA binding 1.24336280073688 bayes_pls_golite062009
transcription factor activity 1.20660383756339 bayes_pls_golite062009
myosin phosphatase activity 0.963950527497681 bayes_pls_golite062009
RNA cap binding 0.85857824809712 bayes_pls_golite062009
cadherin binding 0.83615873409529 bayes_pls_golite062009
translation initiation factor activity 0.83079633551839 bayes_pls_golite062009
translation regulator activity 0.82193201542158 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.803700928110921 bayes_pls_golite062009
cell adhesion molecule binding 0.65899395557033 bayes_pls_golite062009
protein serine/threonine kinase activity 0.638990331710836 bayes_pls_golite062009
signal transducer activity 0.611492201912646 bayes_pls_golite062009
molecular transducer activity 0.611492201912646 bayes_pls_golite062009
protein phosphatase binding 0.21324446893915 bayes_pls_golite062009
transcription activator activity 0.160275383613705 bayes_pls_golite062009
phosphatase binding 0.12473988003504 bayes_pls_golite062009
transcription factor binding 0.0221966060394205 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [607-667] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FPVKDSGEPS VPRADKNHFP RPTVPGEDMG KGPVYQLRGD TRDTLAQLGI AELVHFSQST  60
   61 D

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 33.39794
Match: 1wa5B
Description: Crystal structure of the exportin Cse1p complexed with its cargo ( Kap60p) and RanGTP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphoprotein phosphatase activity 7.41566231556356 bayes_pls_golite062009
phosphatase activity 6.2815295903206 bayes_pls_golite062009
protein serine/threonine phosphatase activity 6.23975872771765 bayes_pls_golite062009
phosphoric ester hydrolase activity 6.04343158483355 bayes_pls_golite062009
protein phosphatase type 2A regulator activity 5.96826345560807 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 5.13001603767079 bayes_pls_golite062009
binding 3.0667965351474 bayes_pls_golite062009
protein binding 2.78733902345842 bayes_pls_golite062009
phosphatase regulator activity 2.6399267580941 bayes_pls_golite062009
cytoskeletal protein binding 2.61566088685247 bayes_pls_golite062009
protein phosphatase regulator activity 2.60055057218296 bayes_pls_golite062009
nucleic acid binding 2.44247330635325 bayes_pls_golite062009
actin binding 2.3058296268212 bayes_pls_golite062009
transcription regulator activity 2.16673352512615 bayes_pls_golite062009
hydrolase activity 1.97016752220053 bayes_pls_golite062009
DNA binding 1.95242774903625 bayes_pls_golite062009
RNA binding 1.93705682476038 bayes_pls_golite062009
structural molecule activity 1.66077840765881 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.62227684952907 bayes_pls_golite062009
kinase activity 1.60994283310715 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.50380925936701 bayes_pls_golite062009
protein kinase activity 1.39674032951965 bayes_pls_golite062009
transferase activity 1.25186057612742 bayes_pls_golite062009
mRNA binding 1.24336280073688 bayes_pls_golite062009
transcription factor activity 1.20660383756339 bayes_pls_golite062009
myosin phosphatase activity 0.963950527497681 bayes_pls_golite062009
RNA cap binding 0.85857824809712 bayes_pls_golite062009
cadherin binding 0.83615873409529 bayes_pls_golite062009
translation initiation factor activity 0.83079633551839 bayes_pls_golite062009
translation regulator activity 0.82193201542158 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.803700928110921 bayes_pls_golite062009
cell adhesion molecule binding 0.65899395557033 bayes_pls_golite062009
protein serine/threonine kinase activity 0.638990331710836 bayes_pls_golite062009
signal transducer activity 0.611492201912646 bayes_pls_golite062009
molecular transducer activity 0.611492201912646 bayes_pls_golite062009
protein phosphatase binding 0.21324446893915 bayes_pls_golite062009
transcription activator activity 0.160275383613705 bayes_pls_golite062009
phosphatase binding 0.12473988003504 bayes_pls_golite062009
transcription factor binding 0.0221966060394205 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle