Protein Overview: TPA_RAT

General Information:
Name(s) found:	TPA_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|42476137\|ref\|NP_037283.2\| plasminogen activator, tissue [Rattus norvegicus] [NCBI NR] gi\|38181951\|gb\|AAH61565.1\| Plasminogen activator, tissue [Rattus norvegicus] [NCBI NR] gi\|207431\|gb\|AAA42261.1\| tissue-type plasminogen activator protein [NCBI NR] gi\|149057771\|gb\|EDM09014.1\| plasminogen activator, tissue, isoform CRA_a [Rattus norvegicus] [NCBI NR] gi\|149057770\|gb\|EDM09013.1\| plasminogen activator, tissue, isoform CRA_a [Rattus norvegicus] [NCBI NR] gi\|137121\|sp\|P19637.2\|TPA_RAT RecName: Full=Tissue-type plasminogen activator; Short=t-plasminogen activator; Short=t-PA; Short=tPA; Contains: RecName: Full=Tissue-type plasminogen activator chain A; Contains: RecName: Full=Tissue-type plasminogen activat [NCBI NR] pir\|\|A35029 t-plasminogen activator (EC 3.4.21.68) precursor - rat [NCBI NR] Tissue-type plasminogen activator OS=Rattus norvegicus GN=Plat PE=2 SV=2 [Swiss-Prot] plasminogen activator, tissue [HMR_022704-rand.fasta] plasminogen activator, tissue [Rattus norvegicus]gi\|38181951\|gb\|AAH61565.1\| Plasminogen activator, tissue [Rattus norvegicus]gi\|112153\|pir\|\|A35029 t-plasminogen activator (EC 3.4.21.68) precursor - ratgi\|137121\|sp\|P19637\|TPA_RAT Tissue-type plasminogen [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Tissue-type plasminogen activator precursor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] plasminogen activator, tissue [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tissue-type plasminogen activator precursor (t-plasminogen activator) (t-PA) (tPA) [Contains: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] plasminogen activator, tissue, isoform CRA_a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Plasminogen activator, tissue [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] tissue-type plasminogen activator protein [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 TISSUE-TYPE PLASMINOGEN ACTIVATOR PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tissue-type plasminogen activator precursor (tPA) (t-PA) (t-plasminogen activator) [Contains: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B] [nr-271106-contam.fasta] Tax_Id=10116 Gene_Symbol=Plat Tissue-type plasminogen activator [rat-ipi-250309-contam.fasta] Tissue-type plasminogen activator OS=Rattus norvegicus GN=Plat [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	559 amino acids
Gene Ontology:
Cellular Component:	extracellular space [UNKNOWN][IDA] apical part of cell [UNKNOWN][IEA] cytoplasm [UNKNOWN][IDA] secretory granule [UNKNOWN][IEA] [NOT]extracellular matrix [UNKNOWN] synapse [IDA] extracellular region [UNKNOWN][IEA] cell surface [UNKNOWN]
Biological Process:	smooth muscle cell migration [UNKNOWN][IEA] response to hypoxia [UNKNOWN][IEA] proteolysis [UNKNOWN][IEA] regulation of synaptic plasticity [IEP] response to glucocorticoid stimulus [IEP] platelet-derived growth factor receptor signaling pathway [UNKNOWN][IEA] blood vessel morphogenesis [IEP] response to cAMP [IEP] negative regulation of proteolysis [UNKNOWN] response to peptide hormone stimulus [IEP] synaptic transmission, glutamatergic [IMP]
Molecular Function:	protein binding [UNKNOWN] serine-type endopeptidase activity [UNKNOWN][IEA] peptidase activity [IEA] molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKGELLCVLL LCGVAFTLPD QGIHRRFRRG ARSYRATCRD EQTQTTYQQH QSWLRPMLRG  60
   61 NRVEYCRCNS GLAQCHSVPV RSCSEPRCFN GGTCQQALYF SDFVCQCPDG FVGKRCDIDT 120
  121 RATCFEGQGI TYRGTWSTAE NGAECINWNS SALSQKPYSA RRPNAIKLGL GNHNYCRNPD 180
  181 RDVKPWCYVF KAGKYTTEFC STPACPKGPT EDCYVGKGVT YRGTHSFTTS KASCLPWNSM 240
  241 ILIGKTYTAW RANSQALGLG RHNYCRNPDG DAKPWCHVMK DRKLTWEYCD MSPCSTCGLR 300
  301 QYKQPQFRIK GGLFTDITSH PWQAAIFVKN KRSPGERFLC GGVLISSCWV LSAAHCFVER 360
  361 FPPHHLKVVL GRTYRVVPGE EEQTFEIEKY IVHKEFDDDT YDNDIALLQL RSDSSQCAQE 420
  421 SSSVGTACLP DPDVQLPDWT ECELSGYGKH EASSPFFSDR LKEAHVRLYP SSRCTSQHLF 480
  481 NKTITSNMLC AGDTRTGGNQ DVHDACQGDS GGPLVCMIDK RMTLLGIISW GLGCGQKDVP 540
  541 GIYTKVTNYL NWIQDNMKQ

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: TPA_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: