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Protein Overview: PDGFB_RAT

General Information:
Name(s) found: PDGFB_RAT [Swiss-Prot]
Description(s) found:
Found 9 descriptions.
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  • Platelet-derived growth factor subunit B (Fragment) OS=Rattus norvegicus GN=Pdgfb PE=2 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 225 amino acids

    Gene Ontology:
    Cellular Component: platelet alpha granule lumen [UNKNOWN]
    cytoplasm [IDA]
    membrane [IEA]
    extracellular region [UNKNOWN][IEA]
    cell surface [UNKNOWN][IEA]
    Biological Process: positive regulation of MAP kinase activity [UNKNOWN][IEA]
    response to estrogen stimulus [IEP]
    DNA replication [IEP]
    cell projection assembly [UNKNOWN][IEA]
    positive regulation of cell proliferation [UNKNOWN]
    transforming growth factor beta receptor signaling pathway [IMP]
    response to wounding [UNKNOWN]
    positive regulation of fibroblast growth factor receptor signaling pathway [UNKNOWN][IEA]
    positive regulation of DNA replication [UNKNOWN][IEA]
    epithelial cell proliferation involved in salivary gland morphogenesis [UNKNOWN][IEA]
    branching involved in salivary gland morphogenesis [UNKNOWN][IEA]
    cell chemotaxis [UNKNOWN][IEA]
    positive regulation of smooth muscle cell proliferation [IMP]
    regulation of peptidyl-tyrosine phosphorylation [UNKNOWN][IEA]
    wound healing [IEP]
    response to hypoxia [IEP]
    response to insulin stimulus [IEP]
    positive regulation of cell division [IEA]
    positive regulation of fibroblast proliferation [UNKNOWN][IEA]
    negative regulation of phosphatidylinositol biosynthetic process [UNKNOWN][IEA]
    positive regulation of smooth muscle cell migration [UNKNOWN][IMP]
    response to organic substance [IEP]
    platelet-derived growth factor receptor signaling pathway [UNKNOWN][IMP]
    response to organic cyclic substance [IEP]
    regulation of cell proliferation [IEP]
    positive regulation of blood vessel endothelial cell migration [UNKNOWN][IEA]
    monocyte chemotaxis [UNKNOWN][IEA]
    response to drug [IEP]
    response to estradiol stimulus [IEP]
    negative regulation of platelet activation [UNKNOWN][IEA]
    substrate-bound cell migration [UNKNOWN][IEA]
    positive regulation of endothelial cell proliferation [UNKNOWN][IEA]
    actin cytoskeleton organization [UNKNOWN][IEA]
    positive regulation of chemotaxis [UNKNOWN][IEA]
    cellular response to mycophenolic acid [IDA]
    cell growth [IEP]
    negative regulation of cell migration [UNKNOWN][IEA]
    Molecular Function: growth factor activity [IEA]
    protein binding [UNKNOWN]
    protein homodimerization activity [UNKNOWN][IEA]
    platelet-derived growth factor receptor binding [UNKNOWN][IMP]
    collagen binding [UNKNOWN][IEA]
    protein heterodimerization activity [UNKNOWN][IEA]
    cell surface binding [UNKNOWN][IEA]
    platelet-derived growth factor binding [UNKNOWN][IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPLCCYLRLV SAEGDPIPEE LYEMLSDHSI RSFDDLQRLL HRDSVDEDGA ELDLNMTRAH  60
   61 SGVESESSSR GRRSLGSLAA AEPAVIAECK TRTEVFQISR NLIDRTNANF LVWPPCVEVQ 120
  121 RCSGCCNNRN VQCRASQVQM RPVQVRKIEI VRKKPVFKKA TVTLEDHLAC KCETVVTPRP 180
  181 VTRSPGTSRE HRAKTPQTRV TVRTVRIRRP PKGKHRKFKH THDKK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle