Protein Overview: ENPP1_RAT

General Information:
Name(s) found:	ENPP1_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|23396766\|sp\|Q924C3.2\|ENPP1_RAT RecName: Full=Ectonucleotide pyrophosphatase/phosphodiesterase family member 1; Short=E-NPP 1; AltName: Full=Phosphodiesterase I/nucleotide pyrophosphatase 1; AltName: Full=Plasma-cell membrane glycoprotein PC-1; Includes [NCBI NR] gi\|16758300\|ref\|NP_445987.1\| ectonucleotide pyrophosphatase/phosphodiesterase 1 [Rattus norvegicus] [NCBI NR] gi\|14582808\|gb\|AAK69654.1\|AF340186_1 ecto-nucleotide pyrophosphatase/phosphodiesterase-1 [Rattus norvegicus] [NCBI NR] (Q924C3) Ectonucleotide pyrophosphatase/phosphodiesterase 1 (E-NPP 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (E [Swiss-Prot] Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 OS=Rattus norvegicus GN=Enpp1 PE=1 SV=2 [Swiss-Prot] ectonucleotide pyrophosphatase/phosphodiesterase 1 [HMR_022704-rand.fasta] ectonucleotide pyrophosphatase/phosphodiesterase 1 [Rattus norvegicus]gi\|14582808\|gb\|AAK69654.1\| ecto-nucleotide pyrophosphatase/phosphodiesterase-1 [Rattus norvegicus]gi\|23396766\|sp\|Q924C3\|NPP1_RAT Ectonucleotide pyrophosphatase/phosphodiesterase 1 (E- [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Splice Isoform 2 of Ectonucleotide pyrophosphatase/phosphodiesterase 1 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_053535) ectonucleotide pyrophosphatase/phosphodiesterase 1 [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (E-NPP 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Includes: Alkaline phosphodiesterase I ; Nucleotide pyrophosphatase (NPPase)] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] ectonucleotide pyrophosphatase/phosphodiesterase 1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] ecto-nucleotide pyrophosphatase/phosphodiesterase-1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Ectonucleotide pyrophosphatase/phosphodiesterase 1 (E-NPP 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Includes: Alkaline phosphodiesterase I ; Nucleotide pyrophosphatase (NPPase)] [nr-271106-contam.fasta] Tax_Id=10116 Gene_Symbol=Enpp1 Isoform 2 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [rat-ipi-250309-contam.fasta] ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Rattus norvegicus] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta] Isoform 2 of Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 OS=Rattus norvegicus GN=Enpp1 [011711_HMR.fasta] Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 OS=Rattus norvegicus GN=Enpp1 PE=2 SV=2 [UNIPROT_RAT_07-21-2011_reversed.fasta]
Organism:	Rattus norvegicus
Length:	906 amino acids
Gene Ontology:
Cellular Component:	extracellular space [UNKNOWN][IEA] integral to membrane [IEA] cellular_component [ND] plasma membrane [UNKNOWN][IEA] cell surface [UNKNOWN][IEA]
Biological Process:	biological_process [ND] generation of precursor metabolites and energy [UNKNOWN][IEA] bone remodeling [UNKNOWN][IEA] nucleoside triphosphate catabolic process [UNKNOWN][IEA] negative regulation of glycogen biosynthetic process [UNKNOWN][IEA] metabolic process [IEA] negative regulation of fat cell differentiation [UNKNOWN][IEA] negative regulation of glucose import [UNKNOWN][IEA] negative regulation of insulin receptor signaling pathway [UNKNOWN][IEA] phosphate metabolic process [UNKNOWN][IEA] cellular response to insulin stimulus [UNKNOWN][IEA] inorganic diphosphate transport [UNKNOWN][IEA] immune response [IEA] negative regulation of cell growth [UNKNOWN][IEA] 3'-phosphoadenosine 5'-phosphosulfate metabolic process [UNKNOWN][IEA] negative regulation of ossification [UNKNOWN][IEA] sequestering of triglyceride [UNKNOWN][IEA] negative regulation of protein amino acid autophosphorylation [UNKNOWN][IEA] cellular phosphate ion homeostasis [UNKNOWN][IEA] biomineral formation [IEA]
Molecular Function:	protein homodimerization activity [UNKNOWN][IEA] scavenger receptor activity [IEA] nucleotide diphosphatase activity [UNKNOWN][IEA] insulin receptor binding [UNKNOWN][IEA] nucleoside-triphosphate diphosphatase activity [UNKNOWN][IEA] molecular_function [ND] nucleic acid binding [IEA] ATP binding [UNKNOWN][IEA] protein binding [UNKNOWN][IEA] phosphodiesterase I activity [IEA] metal ion binding [IEA] hydrolase activity [IEA] polysaccharide binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MERDGEQAGQ GPRHGPAGNG RELESPAAAS LLAPMDLGEE PLEKAERART AKDPNTYKVL  60
   61 SLVLSVCVLT TILGCIFGLK PSCAKEVKSC KGRCFERTFS NCRCDAACVS LGNCCLDFQE 120
  121 TCVEPTHIWT CNKFRCGEKR LSRFVCSCAD DCKAHNDCCI NYSSVCQEKK SWVEEACETI 180
  181 DAPQCPAEFE SPPTLLFSLD GFRAEYLHTW GGLLPVISKL KNCGTYTKNM RPVYPTKTFP 240
  241 NHYSIVTGLY PESHGIIDNK MYDPKMNASF SLKSKEKFNP LWYKGQPIWV TANHQEVRSG 300
  301 TYFWPGSDVE IDGILPDIYK VYNGSVPFEE RILAVLEWLQ LPSYERPHFY TLYLEEPDSS 360
  361 GHSHGPVSSE VIKALQKVDH IVGMLMDGLK DLGLDKCLNL ILISDHGMEQ GSCKKYVYLN 420
  421 KYLGDVNNVK VVYGPAARLR PTEVPETYYS FNYEALAKNL SCRETNQHFR PYLKHFLPKR 480
  481 LHFAKNDRIE PLTFYLDPQW QLALNPSERK YCGSGFHGSD NLFSNMQALF IGYGPAFKHG 540
  541 AEVDSFENIE VYNLMCDLLG LIPAPNNESH GSLNHLLKKP IYTPSHPKEE SFLSQCPIKS 600
  601 VSSDLGCTCD PSIVPIMDFE KQFNLTTDAV EDVYSMTVPN GRPRNLQKQH RVCLLHQQQF 660
  661 LTGYSLDLLM PLWTSYTFLS NDQFSTDDFS NCLYQDLRIP LSPMHKCSYY KSTSKLSYGF 720
  721 LTPPRLNRVS RQIYSEALLT SNIVPMYQSF QVIWQYLHDT VLRRYAQERN GVNVVSGPVF 780
  781 DFDYDGRYDS SEILKQNTRV IRSQENLIPT HFFIVLTSCK QLSESPLKCT ALESSAFLLP 840
  841 HRPDNIESCT HGKQESAWVE ELLALHRARV TDVELITGLS FYQDRQESVS ELLRLKTHLP 900
  901 IFSQED

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: ENPP1_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: