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Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. Catalysis of the hydrolysis of ester linkages within nucleic acids. Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: phosphodiesterase I activity
Acc: GO:0004528
Aspect: Molecular Function
Desc: Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.
Synonyms:
  • exonuclease I activity
  • phosphodiesterase activity
  • alkaline phosphodiesterase activity
  • nucleotide pyrophosphatase/phosphodiesterase I activity
  • PDE I activity
  • 5'-NPDase activity
  • 5'-nucleotide phosphodiesterase activity
  • orthophosphoric diester phosphohydrolase activity
  • 5'NPDE activity
  • 5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity
  • 5'-exonuclease activity
  • oligonucleate 5'-nucleotidohydrolase activity
  • 5'-PDase activity
  • 5'-phosphodiesterase activity
  • 5'-PDE activity
Proteins in PDR annotated with:
   This term: 11 [Search]
   Term or descendants: 11 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004528 - phosphodiesterase I activity (interactive image map)

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