Protein Overview: nas-30

General Information:
Name(s) found:	nas-30 / CE36770 [WormBase]
Description(s) found: Found 13 descriptions. SHOW ALL	WBGene00003548 locus:nas-30 peptidase status:Partially_confirmed UniProt:Q9N2V2 protein_id:AAF60901.2 [WormBase]
Organism:	Caenorhabditis elegans
Length:	710 amino acids
Gene Ontology:
Cellular Component:	membrane [IEA]
Biological Process:	proteolysis [IEA]
Molecular Function:	meprin A activity [IEA] zinc ion binding [IEA] astacin activity [IEA] metallopeptidase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYMIQGCYIP AKSDKILETI FSDAPPVYRQ PRTKAEKIER FRNIARTFSP FVYEVNTTPA  60
   61 PHFDNFIWQQ NAPAVTPEPF TFAPFSFPTL ATVAPPAPGP GGPTLEPFLP TTASPKLLAH 120
  121 NTARMIREIA SFSDGGRSRD QDFGAVQTLM QAFFEAVSSG NNGGAGAAAG AGTALGDAPM 180
  181 LQAHRDGTEL GANRALTNKL FESDMVLTVK QMKAIVLAAQ EARNPHGRKK RKVITGSVYR 240
  241 WKSVIPFRFK GGDAKWKKLI REGLGLWEKE TCVRWSENGP GKDYVIFFRG SGCYSSVGRT 300
  301 GGSQLISIGY GCEDKGIVAH EVGHSLGFWH EQSRPDRDDY IHLRKDWIIK GTDGNFEKRS 360
  361 WEEIEDMGVP YDVGSVMHYG SNAFTKDWDQ ITIETKDSRY QGTIGQRQKL SFIDVKQVNR 420
  421 LYCNSVCPVA LPCMHGGYPD PNNCAVCKCP DGLGGKLCGR AAKGTDHDKC GGELTATAEW 480
  481 QEMVYKGKRT CNWKVKSPSG GRVRLVLTEL RYQCAPACKA YIEIKHNTDF QQTGFRVCCF 540
  541 NKTYDVISDQ SEALILSNAN IVDYEVSYKL QWIQGTPPPP PFLSIERTFF QTTEKLFHHR 600
  601 NPRRPGCPEK RIDHSAEWRT RAAPSKSSSC KRSQRSETRI GHWRVLLVLL RNMVSQRYLV 660
  661 YRIMESSPFG TIFAIVRGIY IYICKFCTIP KIQFFFHNFQ NLLIFHNYSG

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..131]	deduced	N/A	No confident structure predictions are available.
2	View Details	[132..198]	MSA	1.196995	View MSA. No confident structure predictions are available.
3	View Details	[199..346]	PSI-BLAST	38.39794	STRUCTURE OF ASTACIN AND IMPLICATIONS FOR ACTIVATION OF ASTACINS AND ZINC-LIGATION OF COLLAGENASES
4	View Details	[347..575]	PSI-BLAST	23.221849	Mannose-binding protein associated serine protease 2, MASP2
5	View Details	[576..710]	deduced	N/A	No confident structure predictions are available.

Functions predicted (by domain):

#

Gene Ontology predictions

1

No functions predicted.

2

No functions predicted.

3

Term	Confidence	Notes
peptidase activity	3.87713655504947	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	3.50720289959102	bayes_pls_golite062009
metallopeptidase activity	2.55317823694462	bayes_pls_golite062009
endopeptidase activity	2.52973705827479	bayes_pls_golite062009
hydrolase activity	2.30803642767787	bayes_pls_golite062009
metalloendopeptidase activity	1.81132179546381	bayes_pls_golite062009
catalytic activity	1.26162753036584	bayes_pls_golite062009
exopeptidase activity	0.71491631246151	bayes_pls_golite062009
binding	0.499447555214981	bayes_pls_golite062009

4

Term	Confidence	Notes
peptidase activity	1.72322649047672	bayes_pls_golite062009
binding	1.49179346522265	bayes_pls_golite062009
protein binding	1.279921135544	bayes_pls_golite062009
receptor binding	1.07208480206832	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	0.759649002808058	bayes_pls_golite062009
hydrolase activity	0.647380592098528	bayes_pls_golite062009
endopeptidase activity	0.58509255952441	bayes_pls_golite062009
ErbB-2 class receptor binding	0.437338899624441	bayes_pls_golite062009
catalytic activity	0.34605294925773	bayes_pls_golite062009
ErbB-3 class receptor binding	0.17164197559882	bayes_pls_golite062009
transcription regulator activity	0.0602233721007337	bayes_pls_golite062009
growth factor activity	0.04792804882584	bayes_pls_golite062009

5

No functions predicted.

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.71

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle