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View Structure Prediction Details

Protein: nas-30
Organism: Caenorhabditis elegans
Length: 710 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for nas-30.

Description E-value Query
Range
Subject
Range
gi|17510711, gi|... - gi|57012975|sp|Q9N2V2.3|NAS30_CAEEL RecName: Full=Zinc metalloproteinase nas-30; AltName: Full=Nemat...
650.0 [0..1] [710..37]

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Predicted Domain #1
Region A:
Residues: [1-131]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYMIQGCYIP AKSDKILETI FSDAPPVYRQ PRTKAEKIER FRNIARTFSP FVYEVNTTPA  60
   61 PHFDNFIWQQ NAPAVTPEPF TFAPFSFPTL ATVAPPAPGP GGPTLEPFLP TTASPKLLAH 120
  121 NTARMIREIA S

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [132-198]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FSDGGRSRDQ DFGAVQTLMQ AFFEAVSSGN NGGAGAAAGA GTALGDAPML QAHRDGTELG  60
   61 ANRALTN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [199-346]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KLFESDMVLT VKQMKAIVLA AQEARNPHGR KKRKVITGSV YRWKSVIPFR FKGGDAKWKK  60
   61 LIREGLGLWE KETCVRWSEN GPGKDYVIFF RGSGCYSSVG RTGGSQLISI GYGCEDKGIV 120
  121 AHEVGHSLGF WHEQSRPDRD DYIHLRKD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 38.39794
Match: 1astA
Description: STRUCTURE OF ASTACIN AND IMPLICATIONS FOR ACTIVATION OF ASTACINS AND ZINC-LIGATION OF COLLAGENASES
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 3.87713655504947 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 3.50720289959102 bayes_pls_golite062009
metallopeptidase activity 2.55317823694462 bayes_pls_golite062009
endopeptidase activity 2.52973705827479 bayes_pls_golite062009
hydrolase activity 2.30803642767787 bayes_pls_golite062009
metalloendopeptidase activity 1.81132179546381 bayes_pls_golite062009
catalytic activity 1.26162753036584 bayes_pls_golite062009
exopeptidase activity 0.71491631246151 bayes_pls_golite062009
binding 0.499447555214981 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [347-575]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WIIKGTDGNF EKRSWEEIED MGVPYDVGSV MHYGSNAFTK DWDQITIETK DSRYQGTIGQ  60
   61 RQKLSFIDVK QVNRLYCNSV CPVALPCMHG GYPDPNNCAV CKCPDGLGGK LCGRAAKGTD 120
  121 HDKCGGELTA TAEWQEMVYK GKRTCNWKVK SPSGGRVRLV LTELRYQCAP ACKAYIEIKH 180
  181 NTDFQQTGFR VCCFNKTYDV ISDQSEALIL SNANIVDYEV SYKLQWIQG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 23.221849
Match: 1nt0A
Description: Mannose-binding protein associated serine protease 2, MASP2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 1.72322649047672 bayes_pls_golite062009
binding 1.49179346522265 bayes_pls_golite062009
protein binding 1.279921135544 bayes_pls_golite062009
receptor binding 1.07208480206832 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 0.759649002808058 bayes_pls_golite062009
hydrolase activity 0.647380592098528 bayes_pls_golite062009
endopeptidase activity 0.58509255952441 bayes_pls_golite062009
ErbB-2 class receptor binding 0.437338899624441 bayes_pls_golite062009
catalytic activity 0.34605294925773 bayes_pls_golite062009
ErbB-3 class receptor binding 0.17164197559882 bayes_pls_golite062009
transcription regulator activity 0.0602233721007337 bayes_pls_golite062009
growth factor activity 0.04792804882584 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [576-710]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPPPPPFLSI ERTFFQTTEK LFHHRNPRRP GCPEKRIDHS AEWRTRAAPS KSSSCKRSQR  60
   61 SETRIGHWRV LLVLLRNMVS QRYLVYRIME SSPFGTIFAI VRGIYIYICK FCTIPKIQFF 120
  121 FHNFQNLLIF HNYSG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle