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Protein Overview: dpy-31

General Information:
Name(s) found: dpy-31 / CE37139 [WormBase]
Description(s) found:
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  • WBGene00006592 locus:dpy-31 Zinc metalloproteinase dpy-31 status:Confirmed UniProt:P98060 protein_id:CCD70759.1 [WormBase]
  • gi|71989946|ref|NP_001022732.1| DumPY : shorter than wild-type family member (dpy-31) [Caenorhabditis elegans] [NCBI NR]
  • gi|51011291|gb|AAT92065.1| Dumpy : shorter than wild-type protein 31, isoform b, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • Tollish (tolloid and bmp-1 family) protein 2, isoform b [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas]
  • CE37139 WBGene00006592 locus:dpy-31 status:Confirmed SW:P98060 protein_id:AAT92065.1 [wormpep150.fasta]
  • 37139 WBGene00006592 locus:toh-2 status:Confirmed protein_id:AAT92065.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • CE37139 WBGene00006592 locus:toh-2 status:Confirmed TR:Q6AHR4 protein_id:AAT92065.1 [wormpep132.fasta]
  • 37139 WBGene00006592 locus:dpy-31 status:Confirmed SW:P98060 protein_id:AAT92065.1 [wormpep150-phg-orf-ecoli-rand.fasta]
  • CE37139 WBGene00006592 locus:dpy-31 status:Confirmed UniProt:P98060 protein_id:AAT92065.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE37139 WBGene00006592 locus:dpy-31 status:Confirmed UniProt:P98060 protein_id:AAT92065.1| [wormORF-contam.fasta]
  • DumPY : shorter than wild-type family member (dpy-31) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Dumpy : shorter than wild-type protein 31, isoform b [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE37139 WBGene00006592 locus:dpy-31 status:Confirmed UniProt:P98060 protein_id:CCD70759.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE37139 WBGene00006592 locus:dpy-31 status:Confirmed UniProt:P98060 protein_id:CCD70759.1 Zinc metalloproteinase dpy-31 [wormpep246-ecoli-contam.fasta]
  • Isoform of P98060, Isoform b of Zinc metalloproteinase dpy-31 OS=Caenorhabditis elegans GN=dpy-31 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 529 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEALink to PubMed article]
    Biological Process: embryonic development ending in birth or egg hatching [IMPLink to PubMed article]
    proteolysis [IEALink to PubMed article]
    Molecular Function: meprin A activity [IEALink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    astacin activity [IEALink to PubMed article]
    metallopeptidase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHKIFIIFGL LSLCAAHSLR DLSNKDEEDP PSSAPGVRKR RMMSEEDQKT VDYYMDKLNK  60
   61 LADEKHPEEI ERHKNPELVA WDRKRDSVLN PEEQGKFFQG DIVLYPEQAK ALYEQALTEG 120
  121 KTRVKRKFIG SNLRRWDASR PIIYAFDGSH TQREQRIIEL ALEHWHNITC LNFQRNDQAN 180
  181 SGNRIVFTDV DGCASNVGRH PLGEEQLVSL APECIRLGVI AHEVAHALGF WHEQSRPDRD 240
  241 QYVTVRWENI DKDSKGQFLK EDPDDVDNAG VPYDYGSIMH YRSKAFSKFD DLYTISTYVT 300
  301 DYQKTIGQRD QLSFNDIRLM NKIYCSAVCP SKLPCQRGGY TDPRRCDRCR CPDGFTGQYC 360
  361 EQVMPGYGAT CGGKISLTRS TTRISSPGYP REFKEGQECS WLLVAPPGHI VEFQFIGEFE 420
  421 MYCKIRHSLC MDYVEVRNST DFANTGMRYC CYGTPPTRIR SATTDMVVLF RSFYRGGKGF 480
  481 EARARAVPEW GASRNTNLQY SSLYGYVRSE TGGRGSMWRF PFFVTRRPL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run hcp-1 hcp1 IP from december2004 Cheeseman, I.M., et al. (2005)
    View Run hcp-2 hcp2 ip from december Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..85] deduced N/A No confident structure predictions are available.
    2 View Details [86..229] PSI-BLAST 33.0 STRUCTURE OF ASTACIN AND IMPLICATIONS FOR ACTIVATION OF ASTACINS AND ZINC-LIGATION OF COLLAGENASES
    3 View Details [230..529] PSI-BLAST 24.045757 Mannose-binding protein associated serine protease 2, MASP2

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • peptidase activity
    		•  2.03786631670095 bayes_pls_golite062009
  • receptor binding
    		•  1.94948331803509 bayes_pls_golite062009
  • receptor activity
    		•  1.17703206127603 bayes_pls_golite062009
  • hydrolase activity
    		•  1.12447587972667 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  1.10435298721188 bayes_pls_golite062009
  • endopeptidase activity
    		•  1.03668892056053 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  1.02450424977847 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  0.728290475143461 bayes_pls_golite062009
  • binding
    		•  0.708339313156457 bayes_pls_golite062009
  • metallopeptidase activity
    		•  0.623476257655953 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  0.58090527719405 bayes_pls_golite062009
  • metalloendopeptidase activity
    		•  0.508669171144608 bayes_pls_golite062009
  • protein binding
    		•  0.475826109910145 bayes_pls_golite062009
  • transcription factor binding
    		•  0.30492109086541 bayes_pls_golite062009
  • signal transducer activity
    		•  0.266830350139867 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.266830350139867 bayes_pls_golite062009
  • growth factor activity
    		•  0.190406928940325 bayes_pls_golite062009
  • catalytic activity
    		•  0.075748351866431 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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