Protein Overview: ggr-1

General Information:
Name(s) found:	ggr-1 / CE36915 [WormBase]
Description(s) found: SHOW ONLY BEST	WBGene00001586 locus:ggr-1 Glycine receptor subunit beta-type 4 status:Confirmed UniProt:Q09453 protein_id:CAA86760.2 [WormBase] gi\|71981619\|ref\|NP_496306.2\| GABA/Glycine Receptor family (see gbr) family member (ggr-1) [Caenorhabditis elegans] [NCBI NR] gi\|56757652\|sp\|Q09453.2\|GLRB4_CAEEL RecName: Full=Glycine receptor subunit beta-type 4; Flags: Precursor [NCBI NR] gi\|50507463\|emb\|CAA86760.2\| C. elegans protein C09G5.1, partially confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR] Glycine receptor subunit beta-type 4 OS=Caenorhabditis elegans GN=ggr-1 PE=3 SV=2 [Swiss-Prot] Hypothetical protein C09G5.1 [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas] CE36915 WBGene00001586 locus:ggr-1 gamma-aminobutyric-acid receptor (beta-1 subunit) status:Partially_confirmed SW:Q09453 protein_id:CAA86760.2 [wormpep150.fasta] 36915 WBGene00001586 locus:ggr-1 gamma-aminobutyric-acid receptor (beta-1 subunit) status:Partially_confirmed SW:Q09453 protein_id:CAA86760.2 [wormpep130-phg-ecoli-orf-rand.fasta] CE36915 WBGene00001586 locus:ggr-1 gamma-aminobutyric-acid receptor (beta-1 subunit) status:Partially_confirmed UniProt:Q09453 protein_id:CAA86760.2 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta] CE36915 WBGene00001586 locus:ggr-1 gamma-aminobutyric-acid receptor (beta-1 subunit) status:Partially_confirmed UniProt:Q09453 protein_id:CAA86760.2\| [wormORF-contam.fasta] Glycine receptor subunit beta-type 4 precursor [nr-271106-contam.fasta] GABA/Glycine Receptor family (see gbr) family member (ggr-1) [Caenorhabditis elegans] [nr-271106-contam.fasta] [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr] CE36915 WBGene00001586 locus:ggr-1 gamma-aminobutyric-acid receptor (beta-1 subunit) status:Confirmed UniProt:Q09453 protein_id:CAA86760.2 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta] CE36915 WBGene00001586 locus:ggr-1 status:Confirmed UniProt:Q09453 protein_id:CAA86760.2 Glycine receptor subunit beta-type 4 [wormpep246-ecoli-contam.fasta]
Organism:	Caenorhabditis elegans
Length:	473 amino acids
Gene Ontology:
Cellular Component:	postsynaptic membrane [IEA] membrane [IEA] integral to membrane [IEA]
Biological Process:	ion transport [IEA] taxis [IMP] transport [IEA]
Molecular Function:	ligand-gated ion channel activity [ISS] neurotransmitter receptor activity [IEA] extracellular ligand-gated ion channel activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHSLFLKILI YSLMQCVLGQ AEFWDYDENV TQIEEDFKID DVTRILKRVG NYNRNAYPLL  60
   61 DQDLATHVDI QMYIEGMSSF HAQSMDFQVD IYFQEKWVDH RLQHNNTKRI LVKDPKLFGL 120
  121 LWHPDLYFAN ARTASFHDVT QPNFLVWIYP NGTVWYDCRI SLTVLCMQDL ARYPLDSQNC 180
  181 GLRILSYAYD EEQLIIRWNG GNPVEVNRGI RMPDMHLKHI KFYTKRDKYA TGIWSSAVAE 240
  241 FHVDREITHH IIQSYIPTSL IVIISWFSFW LDVEAVPGRV SLSITTLLTL ATQSSAARMA 300
  301 LPQASDVKAI DVWMGTCMAF VFSAMIEFTV VNYCVRRKVR TKIKPRGLSE QVHDMVAQYR 360
  361 EKKDKFNNGN CEISYEMALQ PNEDNATVQR NFEKKEVREM NQASLFVRRS LLPTSKRKTI 420
  421 EDRINRVEEN RKNAQKIDRY SRALFPLAFI IFNIFYWIYY LKYAGSNSPE LLL

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
cation channel activity	11.1823056937132	bayes_pls_golite062009
ion channel activity	11.1753684044644	bayes_pls_golite062009
nicotinic acetylcholine-activated cation-selective channel activity	11.1208555364265	bayes_pls_golite062009
passive transmembrane transporter activity	11.0903806681397	bayes_pls_golite062009
channel activity	11.0903806681397	bayes_pls_golite062009
gated channel activity	11.0397691626728	bayes_pls_golite062009
metal ion transmembrane transporter activity	10.9870635461822	bayes_pls_golite062009
substrate-specific channel activity	10.9375522860542	bayes_pls_golite062009
extracellular ligand-gated ion channel activity	9.75096408199907	bayes_pls_golite062009
excitatory extracellular ligand-gated ion channel activity	9.75096408199907	bayes_pls_golite062009
ligand-gated channel activity	9.34902726749692	bayes_pls_golite062009
ligand-gated ion channel activity	9.34902726749692	bayes_pls_golite062009
acetylcholine binding	8.89748048814778	bayes_pls_golite062009
acetylcholine receptor activity	8.63094174477134	bayes_pls_golite062009
ion transmembrane transporter activity	7.22265353460749	bayes_pls_golite062009
amine binding	7.07838074088669	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	6.7875346065164	bayes_pls_golite062009
cation transmembrane transporter activity	6.75385972663331	bayes_pls_golite062009
neurotransmitter binding	6.11782125343012	bayes_pls_golite062009
neurotransmitter receptor activity	5.97698567435878	bayes_pls_golite062009
chloride channel regulator activity	5.57216711685731	bayes_pls_golite062009
transmembrane receptor activity	5.4080353535498	bayes_pls_golite062009
receptor activity	5.11329651194787	bayes_pls_golite062009
transporter activity	5.11262082564788	bayes_pls_golite062009
transmembrane transporter activity	5.03439798256257	bayes_pls_golite062009
substrate-specific transporter activity	4.91314874981447	bayes_pls_golite062009
molecular transducer activity	4.12549692767753	bayes_pls_golite062009
signal transducer activity	4.12549692767753	bayes_pls_golite062009
G-protein coupled receptor activity	3.09231388867595	bayes_pls_golite062009
beta-amyloid binding	2.86563324406667	bayes_pls_golite062009
binding	2.4916526322278	bayes_pls_golite062009
G-protein coupled amine receptor activity	1.37431949258757	bayes_pls_golite062009
serotonin binding	1.33584589886834	bayes_pls_golite062009
serotonin-activated cation-selective channel activity	1.31324203158511	bayes_pls_golite062009
	1.15330735898282	bayes_pls_golite062009
channel regulator activity	1.13923307634251	bayes_pls_golite062009
toxin binding	1.03329843925063	bayes_pls_golite062009
drug binding	0.64715018605883	bayes_pls_golite062009
protein binding	0.406954670483187	bayes_pls_golite062009
serotonin receptor activity	0.0879353619248899	bayes_pls_golite062009

Source: Reynolds et al. 2008. Manuscript submitted

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..341]	PSI-BLAST	65.0	Refined structure of the nicotinic acetylcholine receptor at 4A resolution.
2	View Details	[342..473]	PSI-BLAST	35.30103	Acetylcholine receptor protein, beta chain

Protein Overview: ggr-1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: