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Protein Overview: FMO1

General Information:
Name(s) found: FMO1 / YHR176W [SGD]
Description(s) found:
Found 22 descriptions.
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  • Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 432 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum membrane [IDALink to PubMed article]
    Biological Process: protein folding [IDALink to PubMed article]
    Molecular Function: monooxygenase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTVNDKKRLA IIGGGPGGLA AARVFSQSLP NFEIEIFVKD YDIGGVWHYP EQKSDGRVMY  60
   61 DHLETNISKK LMQFSGFPFE ENVPLYPSRR NIWEYLKAYY KTFIANKDAI SIHFSTEVTY 120
  121 LKKKNSQWEI TSKDELRTTK SDFDFVIVAS GHYSVPKLPT NIAGLDLWFD NKGAFHSKDF 180
  181 KNCEFAREKV VIVVGNGSSG QDIANQLTTV AKKVYNSIKE PASNQLKAKL IETVQTIDSA 240
  241 DWKNRSVTLS DGRVLQNIDY IIFATGYYYS FPFIEPSVRL EVLGEGVTGD KHSSVNLHNL 300
  301 WEHMIYVKDP TLSFILTPQL VIPFPLSELQ AAIMVEVFCK SLPITTTFDS NACGTHNFPK 360
  361 GKDLEYYAEL QELLNSIPRR VGHFEPVVWD DRLIDLRNSS YTDKEERNVL LAEHAQALKK 420
  421 KKAPYFLPAP HT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen PRM3 FMO1 1 Unpublished Fields Lab Data
    View Screen RPN9 FMO1 1 Unpublished Fields Lab Data
    View Screen SPT2 FMO1 1 Unpublished Fields Lab Data
    View Screen SPT21 FMO1 1 Unpublished Fields Lab Data
    View Screen SPC98 FMO1 1 Unpublished Fields Lab Data
    View Screen VPS17 FMO1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..432] PSI-BLAST 58.221849 Dihydrolipoamide dehydrogenase
    2 View Details [344..432] MSA 4.982996 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity, acting on sulfur group of donors
    		•  1.80282773804132 bayes_pls_golite062009
  • catalytic activity
    		•  1.56773888754354 bayes_pls_golite062009
  • binding
    		•  0.400596507621048 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor
    		•  0.31095562417378 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.173940946090082 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle