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View Structure Prediction Details

Protein: FMO1
Organism: Saccharomyces cerevisiae
Length: 432 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FMO1.

Description E-value Query
Range
Subject
Range
gi|13448672 - gi|13448672|gb|AAK27157.1|AF349449_1 glutathione reductase [Brassica juncea]
1.0E-61 [5..420] [87..508]
gi|2425107 - gi|2425107|gb|AAB70837.1| glutathione reductase (NADPH) [Vitis vinifera]
1.0E-60 [5..420] [85..506]
gi|29893219 - gi|29893219|gb|AAP03132.1| dihydrolipoamide dehydrogenase [Paracoccus denitrificans]
9.0E-60 [4..421] [1..422]
gi|15451194 - gi|15451194|gb|AAK96868.1| Gluthatione reductase, chloroplast precursor [Arabidopsis thaliana]
6.0E-59 [5..420] [86..507]
CE31971 - dihydrolipoamide dehydrogenase status:Confirmed UniProt:O17953 protein_id:CAB05249.2
1.0E-58 [2..421] [25..451]
GSHRP_TOBAC - Glutathione reductase, chloroplastic (Fragment) OS=Nicotiana tabacum GN=GOR PE=1 SV=1
2.0E-58 [5..420] [78..499]
gi|23502768, gi|... - gi|23502768|ref|NP_698895.1| dihydrolipoamide dehydrogenase [Brucella suis 1330], gi|23348787|gb|AAN...
gi|254708909 - gi|254708909|ref|ZP_05170720.1| dihydrolipoamide dehydrogenase [Brucella pinnipedialis B2/94]
gi|254707554 - gi|254707554|ref|ZP_05169382.1| dihydrolipoamide dehydrogenase [Brucella pinnipedialis M163/99/10]
gi|254700562 - gi|254700562|ref|ZP_05162390.1| dihydrolipoamide dehydrogenase [Brucella suis bv. 5 str. 513]
gi|225616943, gi... - gi|225628118|ref|ZP_03786153.1| dihydrolipoamide dehydrogenase [Brucella ceti str. Cudo], gi|2256169...
gi|254715982 - gi|254715982|ref|ZP_05177793.1| dihydrolipoamide dehydrogenase [Brucella ceti M13/05/1]
gi|254713664 - gi|254713664|ref|ZP_05175475.1| dihydrolipoamide dehydrogenase [Brucella ceti M644/93/1]
4.0E-58 [7..421] [3..425]
DLDH_PSEFL - Dihydrolipoyl dehydrogenase OS=Pseudomonas fluorescens GN=lpd PE=1 SV=3
7.0E-58 [3..424] [1..433]

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Predicted Domain #1
Region A:
Residues: [1-432]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTVNDKKRLA IIGGGPGGLA AARVFSQSLP NFEIEIFVKD YDIGGVWHYP EQKSDGRVMY  60
   61 DHLETNISKK LMQFSGFPFE ENVPLYPSRR NIWEYLKAYY KTFIANKDAI SIHFSTEVTY 120
  121 LKKKNSQWEI TSKDELRTTK SDFDFVIVAS GHYSVPKLPT NIAGLDLWFD NKGAFHSKDF 180
  181 KNCEFAREKV VIVVGNGSSG QDIANQLTTV AKKVYNSIKE PASNQLKAKL IETVQTIDSA 240
  241 DWKNRSVTLS DGRVLQNIDY IIFATGYYYS FPFIEPSVRL EVLGEGVTGD KHSSVNLHNL 300
  301 WEHMIYVKDP TLSFILTPQL VIPFPLSELQ AAIMVEVFCK SLPITTTFDS NACGTHNFPK 360
  361 GKDLEYYAEL QELLNSIPRR VGHFEPVVWD DRLIDLRNSS YTDKEERNVL LAEHAQALKK 420
  421 KKAPYFLPAP HT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 58.221849
Match: 1lpfA_
Description: Dihydrolipoamide dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
oxidoreductase activity, acting on sulfur group of donors 1.80282773804132 bayes_pls_golite062009
catalytic activity 1.56773888754354 bayes_pls_golite062009
binding 0.400596507621048 bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor 0.31095562417378 bayes_pls_golite062009
oxidoreductase activity 0.173940946090082 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [344-432]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ITTTFDSNAC GTHNFPKGKD LEYYAELQEL LNSIPRRVGH FEPVVWDDRL IDLRNSSYTD  60
   61 KEERNVLLAE HAQALKKKKA PYFLPAPHT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle