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Protein Overview: CE31971

General Information:
Name(s) found: CE31971 [WormBase]
Description(s) found:
Found 17 descriptions.
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  • WBGene00010794 locus:dld-1 Dihydrolipoyl dehydrogenase, mitochondrial status:Confirmed UniProt:O17953 protein_id:CAB05249.2 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 495 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEALink to PubMed article]
    Biological Process: electron transport [IEALink to PubMed article]
    glutamate biosynthetic process [IEALink to PubMed article]
    nematode larval development [IMPLink to PubMed articleLink to PubMed article]
    removal of superoxide radicals [IEALink to PubMed article]
    glutathione metabolic process [IEALink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    cell redox homeostasis [IEALink to PubMed article]
    growth [IMPLink to PubMed articleLink to PubMed article]
    detoxification of mercury ion [IEALink to PubMed article]
    Molecular Function: disulfide oxidoreductase activity [IEALink to PubMed article]
    NADP or NADPH binding [IEALink to PubMed article]
    oxidoreductase activity [IEALink to PubMed article]
    FAD binding [IEALink to PubMed article]
    oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [IEALink to PubMed article]
    mercury ion binding [IEALink to PubMed article]
    mercury (II) reductase activity [IEALink to PubMed article]
    thioredoxin-disulfide reductase activity [IEALink to PubMed article]
    glutathione-disulfide reductase activity [IEALink to PubMed article]
    dihydrolipoyl dehydrogenase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLSRTTQLP FAKRQFFQVL ARNYSNTQDA DLVVIGGGPG GYVAAIKAAQ LGMKTVCVEK  60
   61 NATLGGTCLN VGCIPSKALL NNSHYLHMAQ HDFAARGIDC TASLNLPKMM EAKSNSVKQL 120
  121 TGGIKQLFKA NKVGHVEGFA TIVGPNTVQA KKNDGSVETI NARNILIASG SEVTPFPGIT 180
  181 IDEKQIVSST GALSLGQVPK KMVVIGAGVI GLELGSVWQR LGAEVTAVEF LGHVGGMGID 240
  241 GEVSKNFQRS LTKQGFKFLL NTKVMGASQN GSTITVEVEG AKDGKKQTLE CDTLLVSVGR 300
  301 RPYTEGLGLS NVQIDLDNRG RVPVNERFQT KVPSIFAIGD VIEGPMLAHK AEDEGILCVE 360
  361 GIAGGPVHID YNCVPSVVYT HPEVAWVGKA EEQLKQEGVA YKIGKFPFVA NSRAKTNNDQ 420
  421 EGFVKVLADK QTDRMLGVHI IGPNAGEMIA EATLAMEYGA SAEDVARVCH PHPTLSEAFR 480
  481 EANLAAYCGK AINNV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run hcp-1 hcp1 IP from december2004 Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..495] PSI-BLAST 111.0 The crystal structure of dihydrolipoamide dehydrogenase and dihydrolipoamide dehydrogenase-binding protein (didomain) subcomplex of human pyruvate dehydrogenase complex.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle