Protein Overview: FLO8

General Information:
Name(s) found:	FLO8 / YER109C [SGD]
Description(s) found: Found 11 descriptions. SHOW ALL	Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene [SGD]
Organism:	Saccharomyces cerevisiae
Length:	799 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA][TAS] cytoplasm [IDA]
Biological Process:	pseudohyphal growth [TAS] flocculation via cell wall protein-carbohydrate interaction [IMP] invasive growth in response to glucose limitation [TAS] biofilm formation [IMP]
Molecular Function:	specific RNA polymerase II transcription factor activity [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSYKVNSSYP DSIPPTEQPY MASQYKQDLQ SNIAMATNSE QQRQQQQQQQ QQQQQWINQP  60
   61 TAENSDLKEK MNCKNTLNEY IFDFLTKSSL KNTAAAFAQD AHLDRDKGQN PVDGPKSKEN 120
  121 NGNQNTFSKV VDTPQGFLYE W*QIFWDIFN TSSSRGGSEF AQQYYQLVLQ EQRQEQIYRS 180
  181 LAVHAARLQH DAERRGEYSN EDIDPMHLAA MMLGNPMAPA VQMRNVNMNP IPIPMVGNPI 240
  241 VNNFSIPPYN NANPTTGATA VAPTAPPSGD FTNVGPTQNR SQNVTGWPVY NYPMQPTTEN 300
  301 PVGNPCNNNT TNNTTNNKSP VNQPKSLKTM HSTDKPNNVP TSKSTRSRSA TSKAKGKVKA 360
  361 GLVAKRRRKN NTATVSAGST NACSPNITTP GSTTSEPAMV GSRVNKTPRS DIATNFRNQA 420
  421 IIFGEEDIYS NSKSSPSLDG ASPSALASKQ PTKVRKNTKK ASTSAFPVES TNKLGGNSVV 480
  481 TGKKRSPPNT RVSRRKSTPS VILNADATKD ENNMLRTFSN TIAPNIHSAP PTKTANSLPF 540
  541 PGINLGSFNK PAVSSPLSSV TESCFDPESG KIAGKNGPKR AVNSKVSASS PLSIATPRSG 600
  601 DAQKQRSSKV PGNVVIKPPH GFSTTNLNIT LKNSKIITSQ NNTVSQELPN GGNILEAQVG 660
  661 NDSRSSKGNR NTLSTPEEKK PSSNNQGYDF DALKNSSSLL FPNQAYASNN RTPNENSNVA 720
  721 DETSASTNSG DNDNTLIQPS SNVGTTLGPQ QTSTNENQNV HSQNLKFGNI GMVEDQGPDY 780
  781 DLNLLDTNEN DFNFINWEG

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#03 Alpha Factor Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	MIG1	FLO8	1	Unpublished Fields Lab Data
View Screen	CAB2	FLO8	1	Unpublished Fields Lab Data
View Screen	KAP104	FLO8	1	Unpublished Fields Lab Data
View Screen	YPT31	FLO8	1	Unpublished Fields Lab Data
View Screen	DMC1	FLO8	1	Unpublished Fields Lab Data
View Screen	BRP1	FLO8	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..189]	MSA	9.018997	View MSA. No confident structure predictions are available.
2	View Details	[190..323]	deduced	N/A	No confident structure predictions are available.
3	View Details	[324..545]	deduced	N/A	No confident structure predictions are available.
4	View Details	[546..798]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2