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Protein Overview: SIR1_ARATH

General Information:
Name(s) found: SIR1_ARATH [Swiss-Prot]
Description(s) found:
Found 13 descriptions.
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  • NAD-dependent protein deacetylase SRT1 OS=Arabidopsis thaliana GN=SRT1 PE=2 SV=1 [Swiss-Prot]
    • Organism: Arabidopsis thaliana
    Length: 473 amino acids

    Gene Ontology:
    Cellular Component: chromatin silencing complex [ISS]
    Biological Process: regulation of transcription, DNA-dependent [IEA][ISS]
    protein amino acid deacetylation [IEA]
    chromatin silencing [IEA][ISS]
    Molecular Function: DNA binding [IEA][ISS]
    zinc ion binding [IEA]
    NAD or NADH binding [IEA]
    NAD-dependent histone deacetylase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLGYAEKLS FIEDVGQVGM AEFFDPSHLL QCKIEELAKL IQKSKHLVVF TGAGISTSCG  60
   61 IPDFRGPKGI WTLQREGKDL PKASLPFHRA MPSMTHMALV ELERAGILKF VISQNVDGLH 120
  121 LRSGIPREKL SELHGDSFME MCPSCGAEYL RDFEVETIGL KETSRKCSVE KCGAKLKDTV 180
  181 LDWEDALPPK EIDPAEKHCK KADLVLCLGT SLQITPACNL PLKCLKGGGK IVIVNLQKTP 240
  241 KDKKANVVIH GLVDKVVAGV MESLNMKIPP YVRIDLFQII LTQSISGDQR FINWTLRVAS 300
  301 VHGLTSQLPF IKSIEVSFSD NHNYKDAVLD KQPFLMKRRT ARNETFDIFF KVNYSDGCDC 360
  361 VSTQLSLPFE FKISTEEHVE IIDKEAVLQS LREKAVEESS CGQSGVVERR VVSEPRSEAV 420
  421 VYATVTSLRT YHSQQSLLAN GDLKWKLEGS GTSRKRSRTG KRKSKALAEE TKA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..267] PSI-BLAST 67.69897 AF1676, Sir2 homolog (Sir2-AF1?)
    2 View Details [268..473] MSA 20.157997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein deacetylase activity
    		•  9.15022242957651 bayes_pls_golite062009
  • histone deacetylase activity
    		•  9.04876491350231 bayes_pls_golite062009
  • NAD-dependent protein deacetylase activity
    		•  8.13038616303736 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity
    		•  8.13038616303736 bayes_pls_golite062009
  • deacetylase activity
    		•  8.11496387956068 bayes_pls_golite062009
  • histone deacetylase activity (H3-K14 specific)
    		•  6.02509672218091 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  5.83127897351395 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity (H3-K9 specific)
    		•  4.76068488405318 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity (H3-K14 specific)
    		•  4.76068488405318 bayes_pls_golite062009
  • histone deacetylase activity (H3-K9 specific)
    		•  3.4896257195243 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity (H4-K16 specific)
    		•  3.45714518480692 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.9155913558118 bayes_pls_golite062009
  • DNA binding
    		•  2.43141001866996 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.41433477472968 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.24657784428979 bayes_pls_golite062009
  • binding
    		•  2.06552694538163 bayes_pls_golite062009
  • histone binding
    		•  1.71445510915336 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.64212790017753 bayes_pls_golite062009
  • nucleosome binding
    		•  1.5125174755597 bayes_pls_golite062009
  • transcription factor activity
    		•  1.30143289828088 bayes_pls_golite062009
  • transporter activity
    		•  1.23939100911116 bayes_pls_golite062009
  • transcription factor binding
    		•  1.14766678956419 bayes_pls_golite062009
  • tubulin deacetylase activity
    		•  1.11434618720209 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.07379627981357 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.961690831509865 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.82062598660259 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.7975957649836 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.77616501068364 bayes_pls_golite062009
  • catalytic activity
    		•  0.739210399081789 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  0.5949973363213 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.57969598853155 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.54005617175343 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  0.53162622210835 bayes_pls_golite062009
  • transferase activity
    		•  0.483523935618287 bayes_pls_golite062009
  • protein binding
    		•  0.475479132768057 bayes_pls_golite062009
  • hydrolase activity
    		•  0.454589093015975 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  0.114062221123972 bayes_pls_golite062009
  • NAD+ ADP-ribosyltransferase activity
    		•  0.0099486881187274 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle