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Protein Overview: SMC4_ARATH

General Information:
Name(s) found: SMC4_ARATH [Swiss-Prot]
Description(s) found:
Found 12 descriptions.
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  • Structural maintenance of chromosomes protein 4 OS=Arabidopsis thaliana GN=SMC4 PE=1 SV=1 [Swiss-Prot]
    • Organism: Arabidopsis thaliana
    Length: 1241 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS]
    chromosome [IEA]
    Biological Process: chromosome organization [IEA]
    chromosome segregation [ISS]
    Molecular Function: ATP binding [ISS]
    transporter activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEEDEPMGGG ESEPEQRKSG TPRLYIKELV MRNFKSYAGE QRVGPFHKSF SAVVGPNGSG  60
   61 KSNVIDAMLF VFGKRAKQMR LNKVSELIHN STNHQNLDSA GVSVQFEEII DLENGLYETV 120
  121 PGSDFMITRV AFRDNSSKYY INERSSNFTE VTKKLKGKGV DLDNNRFLIL QGEVEQISLM 180
  181 KPKAQGPHDE GFLEYLEDII GTNKYVEKID ELNKQLETLN ESRSGVVQMV KLAEKERDNL 240
  241 EGLKDEAETY MLKELSHLKW QEKATKMAYE DTVAKITEQR DSLQNLENSL KDERVKMDES 300
  301 NEELKKFESV HEKHKKRQEV LDNELRACKE KFKEFERQDV KHREDLKHVK QKIKKLEDKL 360
  361 EKDSSKIGDM TKESEDSSNL IPKLQENIPK LQKVLLDEEK KLEEIKAIAK VETEGYRSEL 420
  421 TKIRAELEPW EKDLIVHRGK LDVASSESEL LSKKHEAALK AFTDAQKQLS DISTRKKEKA 480
  481 AATTSWKADI KKKKQEAIEA RKVEEESLKE QETLVPQEQA AREKVAELKS AMNSEKSQNE 540
  541 VLKAVLRAKE NNQIEGIYGR MGDLGAIDAK YDVAISTACA GLDYIVVETT SSAQACVELL 600
  601 RKGNLGFATF MILEKQTDHI HKLKEKVKTP EDVPRLFDLV RVKDERMKLA FYAALGNTVV 660
  661 AKDLDQATRI AYGGNREFRR VVALDGALFE KSGTMSGGGG KARGGRMGTS IRATGVSGEA 720
  721 VANAENELSK IVDMLNNIRE KVGNAVRQYR AAENEVSGLE MELAKSQREI ESLNSEHNYL 780
  781 EKQLASLEAA SQPKTDEIDR LKELKKIISK EEKEIENLEK GSKQLKDKLQ TNIENAGGEK 840
  841 LKGQKAKVEK IQTDIDKNNT EINRCNVQIE TNQKLIKKLT KGIEEATREK ERLEGEKENL 900
  901 HVTFKDITQK AFEIQETYKK TQQLIDEHKD VLTGAKSDYE NLKKSVDELK ASRVDAEFKV 960
  961 QDMKKKYNEL EMREKGYKKK LNDLQIAFTK HMEQIQKDLV DPDKLQATLM DNNLNEACDL1020
 1021 KRALEMVALL EAQLKELNPN LDSIAEYRSK VELYNGRVDE LNSVTQERDD TRKQYDELRK1080
 1081 RRLDEFMAGF NTISLKLKEM YQMITLGGDA ELELVDSLDP FSEGVVFSVR PPKKSWKNIA1140
 1141 NLSGGEKTLS SLALVFALHH YKPTPLYVMD EIDAALDFKN VSIVGHYVKD RTKDAQFIII1200
 1201 SLRNNMFELA DRLVGIYKTD NCTKSITINP GSFAVCQKTP A

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..285] PSI-BLAST 23.30103 Sc Smc1hd:Scc1-C complex, ATPgS
    2 View Details [286..557] FFAS03 2.85 Tropomyosin
    3 View Details [558..767] FFAS03 4.46 Smc hinge domain
    4 View Details [768..1063] deduced N/A No confident structure predictions are available.
    5 View Details [1064..1241] PSI-BLAST 17.0 Structural biochemistry of ATP-driven dimerization and DNA stimulated activation of SMC ATPases.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • nucleoside-triphosphatase activity
    		•  2.69246499202248 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.61582393123755 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.59641929642359 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.59333672868803 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  2.58390156971125 bayes_pls_golite062009
  • binding
    		•  2.4974940028864 bayes_pls_golite062009
  • transporter activity
    		•  2.17383908004663 bayes_pls_golite062009
  • ATPase activity
    		•  2.11122403732968 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.02444700826552 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  1.8908019270286 bayes_pls_golite062009
  • DNA helicase activity
    		•  1.72320119360938 bayes_pls_golite062009
  • microtubule motor activity
    		•  1.6537049553461 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  1.52935820732225 bayes_pls_golite062009
  • hydrolase activity
    		•  1.35268825531078 bayes_pls_golite062009
  • motor activity
    		•  1.34881124154297 bayes_pls_golite062009
  • helicase activity
    		•  1.33212695797068 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.97700154207756 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.89390151223569 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.89390151223569 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.725611289205392 bayes_pls_golite062009
  • nucleotide binding
    		•  0.717697610309727 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.713814218071151 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.713752628021599 bayes_pls_golite062009
  • protein-DNA loading ATPase activity
    		•  0.654899784430321 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.608058786636536 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.579644950922817 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.500462538667228 bayes_pls_golite062009
  • catalytic activity
    		•  0.458437698837681 bayes_pls_golite062009
  • protein binding
    		•  0.378225828131122 bayes_pls_golite062009
  • centromeric DNA binding
    		•  0.322818640526369 bayes_pls_golite062009
  • GTPase activity
    		•  0.265618217985541 bayes_pls_golite062009
  • DNA clamp loader activity
    		•  0.234068677215771 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.2192434828134 bayes_pls_golite062009
  • ATP binding
    		•  0.19169045543599 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.165732470448462 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.162060759063149 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.114463153989353 bayes_pls_golite062009
  • microfilament motor activity
    		•  0.10236059675512 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.081265446432119 bayes_pls_golite062009
  • recombinase activity
    		•  0.0490751527151101 bayes_pls_golite062009
  • actin binding
    		•  0.00482938540552702 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  2.7707163143035 bayes_pls_golite062009
  • protein binding
    		•  1.2343536336523 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.56283355879326 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.511272811276509 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.299763949828861 bayes_pls_golite062009
  • DNA secondary structure binding
    		•  0.284996962785104 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.248383422632029 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.235472660839816 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.233111707634177 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.210107708818734 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.155323194767055 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.101477244722795 bayes_pls_golite062009
  • ATPase activity
    		•  0.08869715759545 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle