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Protein Overview: MDHC1_ARATH

General Information:
Name(s) found: MDHC1_ARATH [Swiss-Prot]
Description(s) found:
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  • pir||B86176 protein F19P19.13 [imported] - Arabidopsis thaliana [NCBI NR]
  • gi|2341034|gb|AAB70434.1| F19P19.13 [Arabidopsis thaliana] [NCBI NR]
  • gi|22137280|gb|AAM91485.1| At1g04410/F19P19_13 [Arabidopsis thaliana] [NCBI NR]
  • gi|21593602|gb|AAM65569.1| putative malate dehydrogenase [Arabidopsis thaliana] [NCBI NR]
  • gi|20148469|gb|AAM10125.1| unknown protein [Arabidopsis thaliana] [NCBI NR]
  • gi|17473717|gb|AAL38310.1| unknown protein [Arabidopsis thaliana] [NCBI NR]
  • gi|15219721|ref|NP_171936.1| malate dehydrogenase, cytosolic, putative [Arabidopsis thaliana] [NCBI NR]
  • gi|15215692|gb|AAK91392.1| At1g04410/F19P19_13 [Arabidopsis thaliana] [NCBI NR]
  • gi|11133509|sp|P93819.2|MDHC1_ARATH RecName: Full=Malate dehydrogenase, cytoplasmic 1 [NCBI NR]
  • (P93819) Malate dehydrogenase, cytoplasmic 1 (EC 1.1.1.37) [Swiss-Prot]
  • Malate dehydrogenase, cytoplasmic 1 OS=Arabidopsis thaliana GN=MDH1 PE=1 SV=2 [Swiss-Prot]
  • putative malate dehydrogenase [Arabidopsis thaliana]gi|22137280|gb|AAM91485.1| At1g04410/F19P19_13 [Arabidopsis thaliana]gi|20148469|gb|AAM10125.1| unknown protein [Arabidopsis thaliana]gi|17473717|gb|AAL38310.1| unknown protein [Arabidopsis thaliana] [nrdb_11152004_Chlamydomonas]
  • Tax_Id=3702 Malate dehydrogenase, cytoplasmic 1 [EBI-IPI_Arabidopsis_3.11_12-06-2005_reversed.fasta]
  • | Symbols: | malate dehydrogenase, cytosolic, putative | chr1:1189417-1191266 REVERSE [TAIR_Arabidopsis_na_04-12-2008_con_reversed.fasta]
  • At1g04410/F19P19_13 [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • unknown protein [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • putative malate dehydrogenase [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • Malate dehydrogenase, cytoplasmic 1 [nr-271106-contam.fasta]
  • malate dehydrogenase/ oxidoreductase [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • F19P19.13 [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • | Symbols: | Lactate/malate dehydrogenase family protein | chr1:1189418-1191267 REVERSE LENGTH=332 [TAIR_A_Thaliana_10_12-14-2010_reversed.fasta]
  • Malate dehydrogenase, cytoplasmic 1 OS=Arabidopsis thaliana GN=At1g04410 PE=1 SV=2 [ARATH-contam.fasta]
    • Organism: Arabidopsis thaliana
    Length: 332 amino acids

    Gene Ontology:
    Cellular Component: chloroplast stroma [IDA]
    nucleus [IDA]
    chloroplast [IDA]
    membrane [IDA]
    apoplast [IDA]
    vacuole [IDA]
    plasma membrane [IDA]
    Biological Process: response to zinc ion [IEP]
    response to salt stress [IEP]
    response to cadmium ion [IEP]
    Molecular Function: L-malate dehydrogenase activity [IEA]
    malate dehydrogenase activity [IEA][ISS]
    oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [IEA]
    oxidoreductase activity [IEA]
    catalytic activity [IEA]
    binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKEPVRVLV TGAAGQIGYA LVPMIARGIM LGADQPVILH MLDIPPAAEA LNGVKMELID  60
   61 AAFPLLKGVV ATTDAVEGCT GVNVAVMVGG FPRKEGMERK DVMSKNVSIY KSQAAALEKH 120
  121 AAPNCKVLVV ANPANTNALI LKEFAPSIPE KNISCLTRLD HNRALGQISE RLSVPVSDVK 180
  181 NVIIWGNHSS SQYPDVNHAK VQTSSGEKPV RELVKDDAWL DGEFISTVQQ RGAAIIKARK 240
  241 LSSALSAASS ACDHIRDWVL GTPEGTFVSM GVYSDGSYSV PSGLIYSFPV TCRNGDWSIV 300
  301 QGLPIDEVSR KKMDLTAEEL KEEKDLAYSC LS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..332] PSI-BLAST 84.39794 Malate dehydrogenase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • malate dehydrogenase activity
    		•  7.69241456337154 bayes_pls_golite062009
  • L-malate dehydrogenase activity
    		•  3.86701960595079 bayes_pls_golite062009
  • malic enzyme activity
    		•  2.98382582538724 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.75947908917144 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  2.58076782195922 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.88605255677599 bayes_pls_golite062009
  • catalytic activity
    		•  1.67029398049886 bayes_pls_golite062009
  • NAD or NADH binding
    		•  1.32276254629683 bayes_pls_golite062009
  • alcohol dehydrogenase (NAD) activity
    		•  1.27032644348698 bayes_pls_golite062009
  • retinol dehydrogenase activity
    		•  1.16811519855038 bayes_pls_golite062009
  • L-lactate dehydrogenase activity
    		•  1.07211664452474 bayes_pls_golite062009
  • lactate dehydrogenase activity
    		•  0.836910434556944 bayes_pls_golite062009
  • alcohol dehydrogenase activity, zinc-dependent
    		•  0.729242797855749 bayes_pls_golite062009
  • coenzyme binding
    		•  0.59785037604907 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  0.527946013169731 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  0.33551402794014 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  0.19685680097448 bayes_pls_golite062009
  • malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity
    		•  0.120195861875768 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.42

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle