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Protein Overview: dlk-1

General Information:
Name(s) found: dlk-1 / CE36155 [WormBase]
Description(s) found:
Found 16 descriptions.
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  • WBGene00001008 locus:dlk-1 Mitogen-activated protein kinase kinase kinase dlk-1 status:Confirmed UniProt:O01700 protein_id:CAE54890.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 577 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEALink to PubMed article]
    synapse [IDALink to PubMed article]
    Biological Process: activation of MAPKK activity [IGILink to PubMed article]
    regulation of synapse organization [IGILink to PubMed article]
    signal transduction [IEALink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    protein amino acid phosphorylation [IEALink to PubMed article]
    Molecular Function: magnesium ion binding [IEALink to PubMed article]
    ATP binding [IEALink to PubMed article]
    protein tyrosine kinase activity [IEALink to PubMed article]
    non-membrane spanning protein tyrosine kinase activity [IEALink to PubMed article]
    protein C-terminus binding [IPILink to PubMed article]
    protein kinase activity [IEALink to PubMed article]
    protein serine/threonine kinase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSTTMVTTL DLVTPTSEEQ PGPAPESSDF STVVLSPDGS ELVTQSAPNT PIQHREQANA  60
   61 EFGQKEGSPD PKNMVAATGN ASKPSLNSFY ADGLGQLRNG LFSCFQPVFG YFGTKTTVEI 120
  121 EKSEDELWEI PFDAISELEW LGSGSQGAVF RGQLENRTVA VKKVNQLKET EIKHLRHLRH 180
  181 QNIIEFLGVC SKSPCYCIVM EYCSKGQLCT VLKSRNTITR ELFAQWVKEI ADGMHYLHQN 240
  241 KVIHRDLKSP NILISAEDSI KICDFGTSHM QKKMDSTMMS FCGTVSWMAP EMIKKQPCNE 300
  301 KVDVYSFGVV LWEMLTRETP YANIAQMAII FGVGTNILSL PMPEEAPKGL VLLIKQCLSQ 360
  361 KGRNRPSFSH IRQHWEIFKP ELFEMTEEEW QLAWDSYREF AKCIQYPSTV TRDHGGPKSA 420
  421 FAMEEEIQRK RHEQLNHIKD IRNMYEMKLK RTNKMYDKLQ GCFTELKLKE SELAEWEKDL 480
  481 TEREQWHNQN SPKAVAAPRA QLRGYPNEGY DDMSSDEDVQ PCRGSPYRCS NTSSSSGVQS 540
  541 SPFSRQSSSR SSAGQQTRRS EGANPPSEYI FPEKLNI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..385] PSI-BLAST 76.69897 No description for 2fo0A was found.
    2 View Details [386..577] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.04467222534257 bayes_pls_golite062009
  • kinase activity
    		•  4.85903980916957 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.63692708178478 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.26787750561728 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • signal transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.81249386965144 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.81145713371725 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  1.7769021678395 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.6878868450299 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.59474164216385 bayes_pls_golite062009
  • receptor activity
    		•  1.57112777506542 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  1.4571078357189 bayes_pls_golite062009
  • protein binding
    		•  1.22565748038754 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.83823250804321 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.610230065465794 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.499492353295369 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • insulin receptor activity
    		•  0.35140991120688 bayes_pls_golite062009
  • insulin binding
    		•  0.326213234151689 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  0.30293890086301 bayes_pls_golite062009
  • kinase binding
    		•  0.26752427107238 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  0.26602283402868 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  0.26602283402868 bayes_pls_golite062009
  • growth factor binding
    		•  0.0526340287295695 bayes_pls_golite062009
  • PTB domain binding
    		•  0.0449060071013108 bayes_pls_golite062009
  • protein kinase binding
    		•  0.00674998152095019 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle