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Protein Overview: lgc-4

General Information:
Name(s) found: lgc-4 / CE35495 [WormBase]
Description(s) found:
Found 19 descriptions.
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  • WBGene00017580 locus:lgc-4 member of the ligand-gated ionic channels family status:Confirmed UniProt:P54245 protein_id:AAA81080.3 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 615 amino acids

    Gene Ontology:
    Cellular Component: postsynaptic membrane [IEALink to PubMed article]
    membrane [IEALink to PubMed article]
    integral to membrane [IEALink to PubMed article]
    Biological Process: ion transport [IEALink to PubMed article]
    transport [IEALink to PubMed article]
    Molecular Function: neurotransmitter receptor activity [IEALink to PubMed article]
    extracellular ligand-gated ion channel activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIICYSCLTV SILLTIKFVP CRFAGIEHQN TKSRVHFSLL DSRQENDTNH FEIAEAKFQK  60
   61 PHNEENTIGT ITKFAPSVQE QHSSAVIPMP HFDQNRLEQA LRIKGSIDGT EEALYRSLLD 120
  121 HTVYEKDVRP CIHHSQPTNV TFGFLLNQIV EMDERNQALT TRSWLNINWM DPRLSWNESL 180
  181 WSEIKAIYIP HARIWKPDII LVNNAIREYY ASLVSTDVMV TSDGNVTWLF SALFRSSCPI 240
  241 RVRYYPFDDQ QCDLKFASWS HDITEINLGL NTDKGDLSSY MNNSEFDLVD MTAVREVVTF 300
  301 PSDTNSDWPI IVIRIHMHRR PLFYVFNHIV PCVLISSMAV LGFLMPPETG EKINMIITTL 360
  361 LSMGVYLQSI TESIPPTSEG VPLIGMYYVS SLLMVCLATC VNVITLNMHR NGAANQGRHV 420
  421 PAWMQKWILG YLATFMRMSI REPDSIALLK ASQSKKSTIR RSSILRDLKR VKNMSNVRAK 480
  481 SKEQNANREC ECMDPLVHIY AESIMSCLAA DTKPMNGSTI REDFASESTF LGRVVSDGIM 540
  541 PRISASSNSV LTEFETRFRR ILKRVYRSLQ QHEIREEILD ERSRIQCSGN NLHLSLIDFY 600
  601 YVFFALQHCS QSSAS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..85] deduced N/A No confident structure predictions are available.
    2 View Details [86..417] PSI-BLAST 83.0 Refined structure of the nicotinic acetylcholine receptor at 4A resolution.
    3 View Details [418..554] PSI-BLAST 41.69897 Acetylcholine receptor protein, beta chain
    4 View Details [555..615] MSA 2.064997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • extracellular ligand-gated ion channel activity
    		•  10.1234885291809 bayes_pls_golite062009
  • excitatory extracellular ligand-gated ion channel activity
    		•  10.1234885291809 bayes_pls_golite062009
  • nicotinic acetylcholine-activated cation-selective channel activity
    		•  10.0780542200909 bayes_pls_golite062009
  • cation channel activity
    		•  8.5858052761298 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  8.57620608456081 bayes_pls_golite062009
  • channel activity
    		•  8.57620608456081 bayes_pls_golite062009
  • ion channel activity
    		•  8.50385648276422 bayes_pls_golite062009
  • gated channel activity
    		•  8.45472729106126 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  8.38189052202481 bayes_pls_golite062009
  • acetylcholine binding
    		•  8.16606736207577 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  8.02211931922735 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  8.02211931922735 bayes_pls_golite062009
  • acetylcholine receptor activity
    		•  7.93415141778179 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  7.84962233148559 bayes_pls_golite062009
  • amine binding
    		•  6.94698730333481 bayes_pls_golite062009
  • chloride channel regulator activity
    		•  4.09042405830166 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  3.69657181531883 bayes_pls_golite062009
  • neurotransmitter binding
    		•  3.68012973608441 bayes_pls_golite062009
  • receptor activity
    		•  3.60196173798811 bayes_pls_golite062009
  • neurotransmitter receptor activity
    		•  3.53144805298686 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  3.03819521978304 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.99543590661304 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.5795406626011 bayes_pls_golite062009
  • signal transducer activity
    		•  2.5795406626011 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.38330137522171 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.33346254375562 bayes_pls_golite062009
  • beta-amyloid binding
    		•  2.17121190042039 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.87616162898157 bayes_pls_golite062009
  • transporter activity
    		•  1.81491862158336 bayes_pls_golite062009
  • binding
    		•  1.72719973055207 bayes_pls_golite062009
  • drug binding
    		•  1.40945164171836 bayes_pls_golite062009
  • protein binding
    		•  0.154593355721805 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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