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Protein Overview: nas-12

General Information:
Name(s) found: nas-12 / CE35408 [WormBase]
Description(s) found:
Found 21 descriptions.
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  • WBGene00003531 locus:nas-12 Zinc metalloproteinase nas-12 status:Partially_confirmed UniProt:Q9XTD6 protein_id:CAA18774.2 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 384 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: proteolysis [IEALink to PubMed article]
    Molecular Function: zinc ion binding [IEALink to PubMed article]
    astacin activity [IEALink to PubMed article]
    metallopeptidase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLYIPQFSIY FCLGYLLLFC KISNAVKQSW EINQELITEA NKEHTVFGDM LLTPAQLIRY  60
   61 ENSKDSDLSI RGVSIKGSSM NRWSNNIVPY VISPQYSPAQ KQILVSSLRY FERVSCFKFV 120
  121 ERTTQNDYLF IVPLDGCYSY VGKIGGRQTL SLAADCIADY IIWHEMMHAI GFEHEHQRPD 180
  181 RDSFIRVDYA NVIPGQMINF DKLKTSHVEY PDIYDFKSIM HYDGYAFGRV DTARRVRLAT 240
  241 MTPLKPGVTL EDNMKFTATD IEKLNRLGQC GARGGQYSNQ GVVASTCQDV ATAVSCEGNR 300
  301 RRGMCKNPFY KQMMIKSCQK TCRLCSYTRM IDEDDDLTPN TTVKSVKCED KHPRCDIYSH 360
  361 NGFCTLPFYD DVRYQLCAKT CNLC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..268] PSI-BLAST 44.69897 STRUCTURE OF ASTACIN AND IMPLICATIONS FOR ACTIVATION OF ASTACINS AND ZINC-LIGATION OF COLLAGENASES
    2 View Details [269..384] FFAS03 0.962 No description for 1zlgA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • peptidase activity
    		•  3.87713655504947 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  3.50720289959102 bayes_pls_golite062009
  • metallopeptidase activity
    		•  2.55317823694462 bayes_pls_golite062009
  • endopeptidase activity
    		•  2.52973705827479 bayes_pls_golite062009
  • hydrolase activity
    		•  2.30803642767787 bayes_pls_golite062009
  • metalloendopeptidase activity
    		•  1.81132179546381 bayes_pls_golite062009
  • catalytic activity
    		•  1.26162753036584 bayes_pls_golite062009
  • exopeptidase activity
    		•  0.71491631246151 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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