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Protein Overview: alh-12

General Information:
Name(s) found: alh-12 / CE34423 [WormBase]
Description(s) found:
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  • WBGene00000118 locus:alh-12 status:Confirmed UniProt:Q7Z1Q2 protein_id:CCD72350.1 [WormBase]
  • gi|71995613|ref|NP_001022931.1| ALdehyde deHydrogenase family member (alh-12) [Caenorhabditis elegans] [NCBI NR]
  • gi|31249868|gb|AAP46269.1| Aldehyde dehydrogenase protein 12, isoform b [Caenorhabditis elegans] [NCBI NR]
  • [wormpep104.fasta]
  • Aldehyde dehydrogenase protein 12, isoform b [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas]
  • CE34423 WBGene00000118 locus:alh-12 status:Confirmed TR:Q7Z1Q2 protein_id:AAP46269.1 [wormpep150.fasta]
  • 34423 WBGene00000118 locus:alh-12 status:Confirmed TR:Q7Z1Q2 protein_id:AAP46269.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • locus:alh-12 status:Partially_confirmed TR:Q7Z1Q2 protein_id:AAP46269.1 [wormpep115.fasta.reversed]
  • CE34423 WBGene00000118 locus:alh-12 status:Confirmed UniProt:Q7Z1Q2_CAEEL protein_id:AAP46269.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE34423 WBGene00000118 locus:alh-12 status:Confirmed UniProt:Q7Z1Q2_CAEEL protein_id:AAP46269.1| [wormORF-contam.fasta]
  • ALdehyde deHydrogenase family member (alh-12) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE34423 WBGene00000118 locus:alh-12 status:Confirmed UniProt:Q7Z1Q2 protein_id:AAP46269.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • CE34423 WBGene00000118 locus:alh-12 status:Confirmed UniProt:Q7Z1Q2 protein_id:CCD72350.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE34423 WBGene00000118 locus:alh-12 status:Confirmed UniProt:Q7Z1Q2 protein_id:CCD72350.1 Aldehyde dehydrogenase [wormpep246-ecoli-contam.fasta]
  • Isoform of Q7Z1Q3, ALdehyde deHydrogenase OS=Caenorhabditis elegans GN=alh-12 PE=1 SV=1 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 430 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial matrix [IEALink to PubMed article]
    cytoplasm [IEALink to PubMed article]
    Biological Process: cellular aldehyde metabolic process [IEALink to PubMed article]
    metabolic process [IEALink to PubMed article]
    10-formyltetrahydrofolate catabolic process [IEALink to PubMed article]
    proline biosynthetic process [IEALink to PubMed article]
    valine metabolic process [IEALink to PubMed article]
    betaine biosynthetic process [IEALink to PubMed article]
    one-carbon metabolic process [IEALink to PubMed article]
    Molecular Function: 1-pyrroline-5-carboxylate dehydrogenase activity [IEALink to PubMed article]
    betaine-aldehyde dehydrogenase activity [IEALink to PubMed article]
    oxidoreductase activity [IEALink to PubMed article]
    aldehyde dehydrogenase [NAD(P)+] activity [IEALink to PubMed article]
    methylmalonate-semialdehyde dehydrogenase (acylating) activity [IEALink to PubMed article]
    formyltetrahydrofolate dehydrogenase activity [IEALink to PubMed article]
    oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVFTVPSDLS GGLYFLNGKR TTIESTETFD VIEPRIGQVV AKCPKATADI VDQYVKAAAD  60
   61 AQSAWGETTA LDRGKVLHKV ADLIREHAEE IAIWEVKTNG KPIYEARCDI ASSADTFDFF 120
  121 GGIATAVLQG DSLELPGGPS QRIAYTRREP YGVVGCIGAW NYPFQTCVWK VAPALAAGNA 180
  181 VVYKPSPFAP ASPVLLGEIL TAAGVPKGVY NVIQGEQEAG VALCEHNLVA KVSFTGSVAS 240
  241 GEAVQRQAAT KNVKPVTLEL GGKSEIIIFD DSDVKSAVAS AMLANFLNQG QVCTNATRVF 300
  301 VQKGILASFT EAIVQEANDK LKVGDPLLED TRVGANINEG HLQRILGYVE SAKQEGGVVL 360
  361 RGGVRVHPTG VEGGAYFEPA IITGLSDEAR AVREEIFGAV MLILPFETEE EVIARANNTT 420
  421 YGLAAGVFSG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..430] PSI-BLAST 128.0 Aldehyde reductase (dehydrogenase), ALDH

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  5.09598561374689 bayes_pls_golite062009
  • oxidoreductase activity
    		•  4.47226217021998 bayes_pls_golite062009
  • methylmalonate-semialdehyde dehydrogenase (acylating) activity
    		•  3.87605237828483 bayes_pls_golite062009
  • succinate-semialdehyde dehydrogenase [NAD(P)+] activity
    		•  3.64672165191647 bayes_pls_golite062009
  • 1-pyrroline-5-carboxylate dehydrogenase activity
    		•  3.49281413016612 bayes_pls_golite062009
  • 3-chloroallyl aldehyde dehydrogenase activity
    		•  3.37049090049734 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
    		•  3.2867555127991 bayes_pls_golite062009
  • aldehyde dehydrogenase (NAD) activity
    		•  2.81851373615334 bayes_pls_golite062009
  • catalytic activity
    		•  2.80804701752928 bayes_pls_golite062009
  • succinate-semialdehyde dehydrogenase activity
    		•  2.71501590413507 bayes_pls_golite062009
  • aldehyde dehydrogenase [NAD(P)+] activity
    		•  2.43250909158896 bayes_pls_golite062009
  • aminobutyraldehyde dehydrogenase activity
    		•  2.35958138496479 bayes_pls_golite062009
  • malonate-semialdehyde dehydrogenase (acetylating) activity
    		•  1.75951883819887 bayes_pls_golite062009
  • retinal dehydrogenase activity
    		•  1.42867174920845 bayes_pls_golite062009
  • glutamate-5-semialdehyde dehydrogenase activity
    		•  0.882678635212924 bayes_pls_golite062009
  • binding
    		•  0.868255071997355 bayes_pls_golite062009
  • benzaldehyde dehydrogenase activity
    		•  0.38785102096584 bayes_pls_golite062009
  • benzaldehyde dehydrogenase (NAD+) activity
    		•  0.23487570676521 bayes_pls_golite062009
  • histidinol dehydrogenase activity
    		•  0.177840865580085 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle