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Protein Overview: mls-2

General Information:
Name(s) found: mls-2 / CE30891 [WormBase]
Description(s) found:
Found 16 descriptions.
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  • WBGene00003377 locus:mls-2 status:Partially_confirmed UniProt:Q18533 protein_id:CCD67080.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 341 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article][IEALink to PubMed article]
    Biological Process: establishment of mitotic spindle orientation [IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    positive regulation of cell proliferation [IMPLink to PubMed article]
    regulation of mesodermal cell fate specification [IMPLink to PubMed article]
    regulation of transcription, DNA-dependent [IEALink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    Molecular Function: transcription factor activity [IEALink to PubMed article]
    sequence-specific DNA binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPTSVMNLPI DMTTMSSQER LEKMSQLPKI ELMEEEEEEE MKPSSDNKIK FNISELLEDD  60
   61 RKPTTQSSPS ASSEDSTNEI EQTAFNFNFD PKMNPISALL QLQQTFLNVG NQQNMISPLT 120
  121 MFPFFGLPTA QLMHFKNMSN PDVNIQSDNG EEKDEKSEGK DGETRDSTGG SPLESDAEDD 180
  181 DDIGRGSDDE ANSSDPSQNR KKKTRTVFSR SQVSQLEMMF ECKRYLSSQE RSNLAQKLHL 240
  241 TETQVKIWFQ NRRNKFKRQA QTDDTNISLQ MHRANVFSIP ATTALTSPIL TIPTTSAGVN 300
  301 MRNMISSPMD ASATAAARFL FGFGTLQAQQ NLNASAQAQN M

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..187] MSA 5.245996 View MSA. No confident structure predictions are available.
    2 View Details [188..341] PSI-BLAST 26.69897 DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURE OF THE ANTENNAPEDIA HOMEODOMAIN FROM DROSOPHILA IN SOLUTION BY 1H NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  4.09839603329852 bayes_pls_golite062009
  • DNA binding
    		•  3.70287146988839 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.64380968064654 bayes_pls_golite062009
  • transcription factor activity
    		•  3.09799997792958 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.60514736539172 bayes_pls_golite062009
  • binding
    		•  2.38790799849051 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.24140562598253 bayes_pls_golite062009
  • transcription activator activity
    		•  2.19769864782568 bayes_pls_golite062009
  • protein binding
    		•  1.88087411289001 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.04797217475639 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.83458785143486 bayes_pls_golite062009
  • chromatin binding
    		•  0.806325172844419 bayes_pls_golite062009
  • transcription factor binding
    		•  0.54291661516816 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.012862302676295 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.72

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle