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Protein Overview: drp-1

General Information:
Name(s) found: drp-1 / CE30172 [WormBase]
Description(s) found:
Found 21 descriptions.
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  • WBGene00001093 locus:drp-1 status:Confirmed UniProt:G5EDY8 protein_id:CCD70525.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 705 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    Biological Process: embryonic development [IMPLink to PubMed article]
    apoptotic mitochondrial changes [IMPLink to PubMed article]
    morphogenesis of an epithelium [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    mitochondrial fission [IMPLink to PubMed article]
    Molecular Function: GTP binding [IEALink to PubMed article][ISSLink to PubMed article]
    GTPase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MENLIPVVNK LQDVFATLGR KEDQIQLPQI VVVGSQSAGK SSVLENLVGR DFLPRGTGIV  60
   61 TRRPLILQLN HVALDDESKR RRSNGTLLTD DWAMFEHTGS KVFTDFDAVR KEIEDETDRV 120
  121 TGVNKGISLL PISLKIYSHR VVSLSLVDLP GITKIPVGDQ PVNIEEQIRE MILLYISNPS 180
  181 SIILAVTPAN QDFATSEPIK LAREVDAGGQ RTLAVLTKLD LMDQGTDAMD VLMGKVIPVK 240
  241 LGIIGVVNRS QQNILDNKLI VDAVKDEQSF MQKKYPTLAS RNGTPYLAKR LNMLLMHHIR 300
  301 NCLPALKARV SIMNAQCQSD LVAFGEPVED KNRTLLQIIT RFATAYTSTI EGTARNIETT 360
  361 ELCGGARICY IFHDTFGRSL ESVNPLENLT QLDILTAIRN ATGPRPALFV PEVSFELLVK 420
  421 RQIQRLEEPS LRCVELVHEE MQRMVQHCGF TTQQEMIRFP RLYDKINEVV SGVLKERLKP 480
  481 TNELVENLVA IELAYINTKH PEFTEANLVT LLKEELLLDD RHGRSRNRHA STGERAQLQP 540
  541 VPGVNGVDLN AVLQQQQQQS QNQRASNGFL GLFGNAAASS KTSPQEKQSA NFLPEVPETQ 600
  601 LGRKLTSREQ RDVAIIERLI RNYFIIVRKN IQDSVPKAIM ALLVNFVRDN LQSELVRQLY 660
  661 KPDEMDDLLA ETEDMAQRRR DTLETMKALQ QASVIISEVR ETQVW

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..327] PSI-BLAST 107.0 Structure of the nucleotide-free myosin II motor domain from Dictyostelium discoideum fused to the GTPase domain of dynamin 1 from Rattus norvegicus
    2 View Details [328..532] MSA 3.301977 View MSA. No confident structure predictions are available.
    3 View Details [533..604] deduced N/A No confident structure predictions are available.
    4 View Details [605..705] Pfam 28.161151 No description for PF02212.9 was found. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transporter activity
    		•  3.10463051760206 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.95886887664984 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.74389108884083 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.67097555143215 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.65161658635465 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.64849912301318 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  2.50494515048649 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  2.39629638016861 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  2.39600931083427 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  2.36051733655256 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  2.35906629925754 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  2.35679406876731 bayes_pls_golite062009
  • ATPase activity
    		•  2.2625504298178 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.24901251684901 bayes_pls_golite062009
  • binding
    		•  2.01755875920323 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.65609907941094 bayes_pls_golite062009
  • motor activity
    		•  1.47133910026814 bayes_pls_golite062009
  • protein transporter activity
    		•  1.37245678118001 bayes_pls_golite062009
  • hydrolase activity
    		•  1.34710139310747 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.3182108176243 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.929901285538132 bayes_pls_golite062009
  • nucleotide binding
    		•  0.922442819194247 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.920987930180051 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.920926158369519 bayes_pls_golite062009
  • microfilament motor activity
    		•  0.723407201613229 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.704934361725919 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.568484017802328 bayes_pls_golite062009
  • actin binding
    		•  0.563996324417607 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  0.46552249844591 bayes_pls_golite062009
  • GTPase activity
    		•  0.437665353870877 bayes_pls_golite062009
  • ATP binding
    		•  0.41092997612902 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.385813421701492 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.377870145186619 bayes_pls_golite062009
  • signal recognition particle binding
    		•  0.29390189699022 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.282397764628576 bayes_pls_golite062009
  • DNA strand annealing activity
    		•  0.0887104483353087 bayes_pls_golite062009
  • protein binding
    		•  0.071010918255742 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.0636334376764289 bayes_pls_golite062009
  • signal transducer activity
    		•  0.0529006651532686 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.0529006651532686 bayes_pls_golite062009
  • macromolecule transmembrane transporter activity
    		•  0.00571427458217011 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven protein transmembrane transporter activity
    		•  0.00571427458217011 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle