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Protein Overview: clh-6

General Information:
Name(s) found: clh-6 / CE29336 [WormBase]
Description(s) found:
Found 23 descriptions.
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  • WBGene00000533 locus:clh-6 status:Confirmed UniProt:G5EC75 protein_id:CAB00111.2 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 796 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEALink to PubMed article]
    integral to membrane [IEALink to PubMed article]
    Biological Process: transmembrane transport [IEALink to PubMed article]
    chloride transport [IEALink to PubMed article]
    Molecular Function: voltage-gated chloride channel activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSRNRVRTS SNSLDPNEDP VSGLERVMSN SNLEHVARQR RRLEEELLFS RQLDDVGRTD  60
   61 SHEALSARYE SLNYEISENR LYRDAEKKPS HQLTLWRISR NRWFVCFLIG VFTGLVAAFI 120
  121 DIMVHYSKDI KFNWILKYLL SKCGEEQRGT TAGCMWTVMI AWIGYNCVLV TIAAILVIYV 180
  181 APIAGGSGIP QIKCYLNGIA IPEVVRLKTL VSKAVGVACS VGGGLCAGKE GPMIHSGAAV 240
  241 GAGISQGKSY SLGIDFGLFR EFRNDREKRD FVSAGAAAGV AAAFGAPIGG VLFSLEEGAS 300
  301 FWNQALTWRM FFSAMISSFT VNWILSWFNG RSGWLSWTGL ANFGVFENKD YNIWEIPLFL 360
  361 LIGIIGGCLG ALFNYLNTKL TEFRKKYVSS KLGRLFECLL VAAVSGFLAF LTIFAIDDCQ 420
  421 PIGANPTATS TQINQMWCKK GEYSAVASLF FQNPEESVKS MFHSPINSFG VTTLVIFGIE 480
  481 YFLLTLWTFG ISVPSGVFIP AILTGAAWGR LFGIFVERLF PSVTGIDPGK YALAGAAAQL 540
  541 GGVVRMTISL TAIIMEATKD ITFGLPIMLV LMVTKWVGDM FNEGLYDAHI DLAEVPILGW 600
  601 NPPKMSRNIL ADRVMRKDVV ALERRERVSR IVEILRSTLH HGFPVVDRIE ESPYESLPDY 660
  661 GRLKGYILRS QLFKLLENRI FEEEGASNSA LPNDFYECQD DDDQMKSVAE LGLTNFDESC 720
  721 FLDIEPYMHP HPHRVPLNTS LPFIFRLFRG LGLRYLFVVN DDNHLRGVIT RKDVARFRER 780
  781 RRNREYHVDE LYISES

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..88] deduced N/A No confident structure predictions are available.
    2 View Details [89..608] PSI-BLAST 54.69897 Clc chloride channel
    3 View Details [609..796] PSI-BLAST 17.69897 No description for 2cu0A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • anion channel activity
    		•  6.77290758049983 bayes_pls_golite062009
  • chloride channel activity
    		•  6.77290758049983 bayes_pls_golite062009
  • anion transmembrane transporter activity
    		•  6.08111514985329 bayes_pls_golite062009
  • voltage-gated chloride channel activity
    		•  5.99544422864122 bayes_pls_golite062009
  • voltage-gated anion channel activity
    		•  5.99544422864122 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  5.07840957725271 bayes_pls_golite062009
  • ion channel activity
    		•  4.93164650815682 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  4.81149777353187 bayes_pls_golite062009
  • channel activity
    		•  4.78965126968592 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  4.78965126968592 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  4.67227438984104 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  4.27956097534048 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  4.255638017629 bayes_pls_golite062009
  • gated channel activity
    		•  4.1072949331811 bayes_pls_golite062009
  • transporter activity
    		•  2.94995161862691 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.84443650880263 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.82470397063503 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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