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Protein Overview: unc-49

General Information:
Name(s) found: unc-49 / CE28082 [WormBase]
Description(s) found:
Found 21 descriptions.
SHOW ALL
  • WBGene00006784 locus:unc-49 status:Confirmed UniProt:G5EBQ0 protein_id:CAC42346.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 487 amino acids

    Gene Ontology:
    Cellular Component: postsynaptic membrane [IEALink to PubMed article]
    membrane [IEALink to PubMed article]
    integral to membrane [IEALink to PubMed article]
    Biological Process: ion transport [IEALink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    regulation of backward locomotion [IMPLink to PubMed article]
    transport [IEALink to PubMed article]
    gamma-aminobutyric acid signaling pathway [IMPLink to PubMed article]
    Molecular Function: neurotransmitter receptor activity [IEALink to PubMed article]
    extracellular ligand-gated ion channel activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MARPFTLIVL LSAHLCLHVV VTQDEDSHIN TQLLSSVLDR LTNRTTYDKR LRPRYGEKPV  60
   61 DVGITIHVSS ISAVSEVDMD FTLDFYMRQT WQDPRLAFGS LDLGLSKEID SLTVGVDYLD 120
  121 RLWKPDTFFP NEKKSFFHLA TTHNSFLRIE GDGTVYTSQR LTVTATCPMD LKLFPMDSQH 180
  181 CKLEIESYGY SILDIMYVSH EKKSVSTESY ELPQFVLQSI KVVNHTQKLS SGEYSRLCWF 240
  241 FLFKRNIGFY IIQIYLPSVL IVVISWVSFW LSRDATPARV ALGVTTVLTM TTLMTMTNSS 300
  301 MPKVSYVKSI DIFLGVCFMM VFCSLLEYAA VGYISKRMKL VRARKESRML TPLPHLESLP 360
  361 PKRTLSVPSY FNNTTYRPFY SSTDQTSNLY IPESQRTTIF SNEDAVPNEL TPMLGRSNSQ 420
  421 ASVFLYQTAV ISDDEFGRFW RWLRPSNIDK YSRSLFPSIF VLFNVGYWAY FIRQSQIQEE 480
  481 QRNSQIL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..341] PSI-BLAST 63.0 Refined structure of the nicotinic acetylcholine receptor at 4A resolution.
    2 View Details [342..487] PSI-BLAST 29.154902 Acetylcholine receptor protein, alpha chain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • cation channel activity
    		•  11.1823056937132 bayes_pls_golite062009
  • ion channel activity
    		•  11.1753684044644 bayes_pls_golite062009
  • nicotinic acetylcholine-activated cation-selective channel activity
    		•  11.1208555364265 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  11.0903806681397 bayes_pls_golite062009
  • channel activity
    		•  11.0903806681397 bayes_pls_golite062009
  • gated channel activity
    		•  11.0397691626728 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  10.9870635461822 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  10.9375522860542 bayes_pls_golite062009
  • extracellular ligand-gated ion channel activity
    		•  9.75096408199907 bayes_pls_golite062009
  • excitatory extracellular ligand-gated ion channel activity
    		•  9.75096408199907 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  9.34902726749692 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  9.34902726749692 bayes_pls_golite062009
  • acetylcholine binding
    		•  8.89748048814778 bayes_pls_golite062009
  • acetylcholine receptor activity
    		•  8.63094174477134 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  7.22265353460749 bayes_pls_golite062009
  • amine binding
    		•  7.07838074088669 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  6.7875346065164 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  6.75385972663331 bayes_pls_golite062009
  • neurotransmitter binding
    		•  6.11782125343012 bayes_pls_golite062009
  • neurotransmitter receptor activity
    		•  5.97698567435878 bayes_pls_golite062009
  • chloride channel regulator activity
    		•  5.57216711685731 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  5.4080353535498 bayes_pls_golite062009
  • receptor activity
    		•  5.11329651194787 bayes_pls_golite062009
  • transporter activity
    		•  5.11262082564788 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  5.03439798256257 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  4.91314874981447 bayes_pls_golite062009
  • molecular transducer activity
    		•  4.12549692767753 bayes_pls_golite062009
  • signal transducer activity
    		•  4.12549692767753 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  3.09231388867595 bayes_pls_golite062009
  • binding
    		•  2.4916526322278 bayes_pls_golite062009
  • beta-amyloid binding
    		•  1.6057916207188 bayes_pls_golite062009
  • G-protein coupled amine receptor activity
    		•  1.37431949258757 bayes_pls_golite062009
  • serotonin binding
    		•  1.33584589886834 bayes_pls_golite062009
  • serotonin-activated cation-selective channel activity
    		•  1.31324203158511 bayes_pls_golite062009
    		• 1.15330735898282 bayes_pls_golite062009
  • channel regulator activity
    		•  1.13923307634251 bayes_pls_golite062009
  • toxin binding
    		•  1.03329843925063 bayes_pls_golite062009
  • drug binding
    		•  0.64715018605883 bayes_pls_golite062009
  • protein binding
    		•  0.406954670483187 bayes_pls_golite062009
  • serotonin receptor activity
    		•  0.0879353619248899 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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    Created and Maintained by: Michael Riffle