| Protein: | unc-49 |
| Organism: | Caenorhabditis elegans |
| Length: | 487 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for unc-49.
| Description | E-value | Query Range |
Subject Range |
|
|
336.0 | [0..2] | [478..122] |
|
Region A: Residues: [1-341] |
1 11 21 31 41 51
| | | | | |
1 MARPFTLIVL LSAHLCLHVV VTQDEDSHIN TQLLSSVLDR LTNRTTYDKR LRPRYGEKPV 60
61 DVGITIHVSS ISAVSEVDMD FTLDFYMRQT WQDPRLAFGS LDLGLSKEID SLTVGVDYLD 120
121 RLWKPDTFFP NEKKSFFHLA TTHNSFLRIE GDGTVYTSQR LTVTATCPMD LKLFPMDSQH 180
181 CKLEIESYGY SILDIMYVSH EKKSVSTESY ELPQFVLQSI KVVNHTQKLS SGEYSRLCWF 240
241 FLFKRNIGFY IIQIYLPSVL IVVISWVSFW LSRDATPARV ALGVTTVLTM TTLMTMTNSS 300
301 MPKVSYVKSI DIFLGVCFMM VFCSLLEYAA VGYISKRMKL V
|
| Detection Method: |  |
| Confidence: | 63.0 |
| Match: | 2bg9A |
| Description: | Refined structure of the nicotinic acetylcholine receptor at 4A resolution. |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [342-487] |
1 11 21 31 41 51
| | | | | |
1 RARKESRMLT PLPHLESLPP KRTLSVPSYF NNTTYRPFYS STDQTSNLYI PESQRTTIFS 60
61 NEDAVPNELT PMLGRSNSQA SVFLYQTAVI SDDEFGRFWR WLRPSNIDKY SRSLFPSIFV 120
121 LFNVGYWAYF IRQSQIQEEQ RNSQIL
|
| Detection Method: | |
| Confidence: | 29.154902 |
| Match: | 1oedA |
| Description: | Acetylcholine receptor protein, alpha chain |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| cation channel activity | 11.1823056937132 | bayes_pls_golite062009 |
| ion channel activity | 11.1753684044644 | bayes_pls_golite062009 |
| nicotinic acetylcholine-activated cation-selective channel activity | 11.1208555364265 | bayes_pls_golite062009 |
| passive transmembrane transporter activity | 11.0903806681397 | bayes_pls_golite062009 |
| channel activity | 11.0903806681397 | bayes_pls_golite062009 |
| gated channel activity | 11.0397691626728 | bayes_pls_golite062009 |
| metal ion transmembrane transporter activity | 10.9870635461822 | bayes_pls_golite062009 |
| substrate-specific channel activity | 10.9375522860542 | bayes_pls_golite062009 |
| extracellular ligand-gated ion channel activity | 9.75096408199907 | bayes_pls_golite062009 |
| excitatory extracellular ligand-gated ion channel activity | 9.75096408199907 | bayes_pls_golite062009 |
| ligand-gated channel activity | 9.34902726749692 | bayes_pls_golite062009 |
| ligand-gated ion channel activity | 9.34902726749692 | bayes_pls_golite062009 |
| acetylcholine binding | 8.89748048814778 | bayes_pls_golite062009 |
| acetylcholine receptor activity | 8.63094174477134 | bayes_pls_golite062009 |
| ion transmembrane transporter activity | 7.22265353460749 | bayes_pls_golite062009 |
| amine binding | 7.07838074088669 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 6.7875346065164 | bayes_pls_golite062009 |
| cation transmembrane transporter activity | 6.75385972663331 | bayes_pls_golite062009 |
| neurotransmitter binding | 6.11782125343012 | bayes_pls_golite062009 |
| neurotransmitter receptor activity | 5.97698567435878 | bayes_pls_golite062009 |
| chloride channel regulator activity | 5.57216711685731 | bayes_pls_golite062009 |
| transmembrane receptor activity | 5.4080353535498 | bayes_pls_golite062009 |
| receptor activity | 5.11329651194787 | bayes_pls_golite062009 |
| transporter activity | 5.11262082564788 | bayes_pls_golite062009 |
| transmembrane transporter activity | 5.03439798256257 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 4.91314874981447 | bayes_pls_golite062009 |
| molecular transducer activity | 4.12549692767753 | bayes_pls_golite062009 |
| signal transducer activity | 4.12549692767753 | bayes_pls_golite062009 |
| G-protein coupled receptor activity | 3.09231388867595 | bayes_pls_golite062009 |
| binding | 2.4916526322278 | bayes_pls_golite062009 |
| beta-amyloid binding | 1.6057916207188 | bayes_pls_golite062009 |
| G-protein coupled amine receptor activity | 1.37431949258757 | bayes_pls_golite062009 |
| serotonin binding | 1.33584589886834 | bayes_pls_golite062009 |
| serotonin-activated cation-selective channel activity | 1.31324203158511 | bayes_pls_golite062009 |
| 1.15330735898282 | bayes_pls_golite062009 | |
| channel regulator activity | 1.13923307634251 | bayes_pls_golite062009 |
| toxin binding | 1.03329843925063 | bayes_pls_golite062009 |
| drug binding | 0.64715018605883 | bayes_pls_golite062009 |
| protein binding | 0.406954670483187 | bayes_pls_golite062009 |
| serotonin receptor activity | 0.0879353619248899 | bayes_pls_golite062009 |
