Protein Overview: ced-12

General Information:
Name(s) found:	ced-12 / CE27228 [WormBase]
Description(s) found: SHOW ONLY BEST	WBGene00000426 locus:ced-12 Cell death abnormality protein 12 status:Confirmed UniProt:Q8STE5 protein_id:CAD12890.1 [WormBase] gi\|75017609\|sp\|Q8STE5.1\|CED12_CAEEL RecName: Full=Cell death abnormality protein 12 [NCBI NR] gi\|17940114\|gb\|AAL49495.1\|AF324505_1 CED-12 [Caenorhabditis elegans] [NCBI NR] gi\|17510859\|ref\|NP_492693.1\| CEll Death abnormality family member (ced-12) [Caenorhabditis elegans] [NCBI NR] gi\|17402868\|emb\|CAD12890.1\| C. elegans protein Y106G6E.5, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR] gi\|17385938\|gb\|AAL38510.1\|AF416781_1 PH domain protein CED-12 [Caenorhabditis elegans] [NCBI NR] Cell death abnormality protein 12 OS=Caenorhabditis elegans GN=ced-12 PE=1 SV=1 [Swiss-Prot] [wormpep67.fasta] CE27228 WBGene00000426 locus:ced-12 status:Confirmed TR:Q8STE5 protein_id:CAD12890.1 [wormpep150.fasta] 27228 WBGene00000426 locus:ced-12 status:Confirmed TR:Q8STE5 protein_id:CAD12890.1 [wormpep130-phg-ecoli-orf-rand.fasta] CEll Death abnormality CED-12, abnormal cell MIGration MIG-16, ELMO, cell-corpse engulfment and cell migration protein (83.1 kD) (ced-12) [Caenorhabditis elegans]gi\|17402868\|emb\|CAD12890.1\| Hypothetical protein Y106G6E.5 [Caenorhabditis elegans]gi\|17940 [nrdb_11152004_Chlamydomonas] locus:ced-12 status:Confirmed TR:Q8STE5 protein_id:CAD12890.1 [wormpep115.fasta.reversed] CE27228 locus:ced-12 status:Confirmed [wormpep80.hongbin] CE27228 WBGene00000426 locus:ced-12 status:Confirmed UniProt:Q8STE5_CAEEL protein_id:CAD12890.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta] CE27228 WBGene00000426 locus:ced-12 status:Confirmed UniProt:Q8STE5_CAEEL protein_id:CAD12890.1\| [wormORF-contam.fasta] Hypothetical protein Y106G6E.5 [Caenorhabditis elegans] [nr-271106-contam.fasta] PH domain protein CED-12 [Caenorhabditis elegans] [nr-271106-contam.fasta] CED-12 [Caenorhabditis elegans] [nr-271106-contam.fasta] CEll Death abnormality family member (ced-12) [Caenorhabditis elegans] [nr-271106-contam.fasta] CE27228 WBGene00000426 locus:ced-12 status:Confirmed UniProt:Q8STE5 protein_id:CAD12890.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta] [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr] CE27228 WBGene00000426 locus:ced-12 status:Confirmed UniProt:Q8STE5 protein_id:CAD12890.1 Cell death abnormality protein 12 [wormpep246-ecoli-contam.fasta]
Organism:	Caenorhabditis elegans
Length:	731 amino acids
Gene Ontology:
Cellular Component:	cytoskeleton [IEA] plasma membrane [IDA]
Biological Process:	gonad morphogenesis [IMP] phagocytosis [IEA] actin filament organization [IDA] engulfment of apoptotic cell [IMP] regulation of cell migration [IMP] cell migration [IMP]
Molecular Function:	SH3 domain binding [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAFHMPLKEL QPVDTSLPEH VVKGAVVIDK EFTIWNHRAV IPSNALHTVF ITINLLEQKL  60
   61 TDVVKMAARS MNLSEDDSYG LMADKPKRFI TDDNLNSLGS GFILTLCASP DHYVKRITEI 120
  121 LTEGNNISQM ENAVKTLDEF SLDPALIEAF YRCSSLELLF SLIRDDRVCM SSTLLSTCLR 180
  181 ALSSMLELAV GDFTWKSVPN DVVVSMASLV TGKAKREEAN TLLAALQMLE QLVIGDDTTR 240
  241 DWILEEVPIE TLIRHVEKSD ERIALCALSL MNSMIRRCPD DEKRFELIKS LEVVPFRNAV 300
  301 HSSLLRGGGG VRNLNAIEQL VEVQRSLISA YETSPPTDAE VQKILDIESS EDVSEEIREM 360
  361 WKSQIGEHRC GRLAAISMVQ FAEKSPQDLR MLISENTMRI EGGKWQLIPM WMRCCDIAAE 420
  421 LFRVIPGRDE LDRLIVVLFS TETPFPAVFA CIVHLFHRTW REMQAKGGEM EKVACVVLEQ 480
  481 LRHVLKRREI QDVEELSADL ETFSYRAMQE IWREEQLGKE NIQLHSEAVI QLKSKLRPKM 540
  541 EELVRINHLN YLKLGAVFRK PQKSKSLAKL AFWHWKLDAS EKMLTITGCD GENYVEGVQR 600
  601 DDIRQVWIKD IADVTNNDEI DRKASSSRFT SSPSTQMLRG IRVQLKTTND MKEGEVLMAL 660
  661 TSDETQSVIW LEGLAELIGS KAVKSETDAM VERMLKMELR VRLLNVKLTN PEEKPEIPPI 720
  721 PDDIKSFISK F

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
transporter activity	2.3766833486706	bayes_pls_golite062009
binding	2.32095856197757	bayes_pls_golite062009
substrate-specific transporter activity	1.87445049214426	bayes_pls_golite062009
protein binding	1.61131270705552	bayes_pls_golite062009
transmembrane transporter activity	1.2724388835449	bayes_pls_golite062009
protein transporter activity	1.10494977623322	bayes_pls_golite062009
signal transducer activity	1.07458868889742	bayes_pls_golite062009
molecular transducer activity	1.07458868889742	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.80477645195818	bayes_pls_golite062009
enzyme regulator activity	0.632985761187158	bayes_pls_golite062009
active transmembrane transporter activity	0.260663498540354	bayes_pls_golite062009
cytoskeletal protein binding	0.187924119511902	bayes_pls_golite062009
clathrin binding	0.0923079381755934	bayes_pls_golite062009
nucleic acid binding	0.0864051685617034	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	0.0342115143082778	bayes_pls_golite062009
GTPase regulator activity	0.0272200107208467	bayes_pls_golite062009
primary active transmembrane transporter activity	0.0128158555898987	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.00672548245940896	bayes_pls_golite062009

Term	Confidence	Notes
binding	2.65091781683225	bayes_pls_golite062009
protein binding	2.12168271674167	bayes_pls_golite062009
GTPase regulator activity	1.66986263418539	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	1.64990514605397	bayes_pls_golite062009
signal transducer activity	1.55319485371003	bayes_pls_golite062009
molecular transducer activity	1.55319485371003	bayes_pls_golite062009
actin binding	1.43478622851729	bayes_pls_golite062009
transporter activity	1.28986800087234	bayes_pls_golite062009
small GTPase regulator activity	1.2550809703725	bayes_pls_golite062009
enzyme regulator activity	1.25381967078645	bayes_pls_golite062009
cytoskeletal protein binding	1.0982866925596	bayes_pls_golite062009
phospholipid binding	1.09683218092034	bayes_pls_golite062009
Rac GTPase activator activity	0.94335238962395	bayes_pls_golite062009
protein complex binding	0.91954220321431	bayes_pls_golite062009
protein domain specific binding	0.90578029954417	bayes_pls_golite062009
small GTPase binding	0.8507658747425	bayes_pls_golite062009
GTPase binding	0.82889812790119	bayes_pls_golite062009
guanyl-nucleotide exchange factor activity	0.745321902095093	bayes_pls_golite062009
phosphoinositide binding	0.71817045430443	bayes_pls_golite062009
substrate-specific transporter activity	0.54401901869178	bayes_pls_golite062009
receptor binding	0.50127063593663	bayes_pls_golite062009
receptor activity	0.353510125274044	bayes_pls_golite062009
actin filament binding	0.34110357372875	bayes_pls_golite062009
transmembrane receptor activity	0.207829786337892	bayes_pls_golite062009
lipid binding	0.179561240451969	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase signaling protein activity	0.13700176999256	bayes_pls_golite062009
receptor signaling protein activity	0.10105990547756	bayes_pls_golite062009

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.90

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..101]	FFAS03	1.58	Crystal structure of mDIA1 GBD-FH3 in complex with RhoC-GMPPNP
2	View Details	[102..532]	FFAS03	1.5	Crystal structure of the dimeric regulatory domain of mouse diaphaneous-related formin (DRF), mDia1
3	View Details	[533..731]	PSI-BLAST	3.69897	STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM PHOSPHOLIPASE C DELTA IN COMPLEX WITH INOSITOL TRISPHOSPHATE

Protein Overview: ced-12

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: