| Protein: | ced-12 |
| Organism: | Caenorhabditis elegans |
| Length: | 731 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ced-12.
| Description | E-value | Query Range |
Subject Range |
|
|
779.0 | [0..18] | [727..4] |
|
Region A: Residues: [1-101] |
1 11 21 31 41 51
| | | | | |
1 MAFHMPLKEL QPVDTSLPEH VVKGAVVIDK EFTIWNHRAV IPSNALHTVF ITINLLEQKL 60
61 TDVVKMAARS MNLSEDDSYG LMADKPKRFI TDDNLNSLGS G
|
| Detection Method: |  |
| Confidence: | 1.58 |
| Match: | 1z2cB |
| Description: | Crystal structure of mDIA1 GBD-FH3 in complex with RhoC-GMPPNP |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [102-532] |
1 11 21 31 41 51
| | | | | |
1 FILTLCASPD HYVKRITEIL TEGNNISQME NAVKTLDEFS LDPALIEAFY RCSSLELLFS 60
61 LIRDDRVCMS STLLSTCLRA LSSMLELAVG DFTWKSVPND VVVSMASLVT GKAKREEANT 120
121 LLAALQMLEQ LVIGDDTTRD WILEEVPIET LIRHVEKSDE RIALCALSLM NSMIRRCPDD 180
181 EKRFELIKSL EVVPFRNAVH SSLLRGGGGV RNLNAIEQLV EVQRSLISAY ETSPPTDAEV 240
241 QKILDIESSE DVSEEIREMW KSQIGEHRCG RLAAISMVQF AEKSPQDLRM LISENTMRIE 300
301 GGKWQLIPMW MRCCDIAAEL FRVIPGRDEL DRLIVVLFST ETPFPAVFAC IVHLFHRTWR 360
361 EMQAKGGEME KVACVVLEQL RHVLKRREIQ DVEELSADLE TFSYRAMQEI WREEQLGKEN 420
421 IQLHSEAVIQ L
|
| Detection Method: | |
| Confidence: | 1.5 |
| Match: | 2bnxA |
| Description: | Crystal structure of the dimeric regulatory domain of mouse diaphaneous-related formin (DRF), mDia1 |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| transporter activity | 2.3766833486706 | bayes_pls_golite062009 |
| binding | 2.32095856197757 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 1.87445049214426 | bayes_pls_golite062009 |
| protein binding | 1.61131270705552 | bayes_pls_golite062009 |
| transmembrane transporter activity | 1.2724388835449 | bayes_pls_golite062009 |
| protein transporter activity | 1.10494977623322 | bayes_pls_golite062009 |
| signal transducer activity | 1.07458868889742 | bayes_pls_golite062009 |
| molecular transducer activity | 1.07458868889742 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 0.80477645195818 | bayes_pls_golite062009 |
| enzyme regulator activity | 0.632985761187158 | bayes_pls_golite062009 |
| active transmembrane transporter activity | 0.260663498540354 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 0.187924119511902 | bayes_pls_golite062009 |
| clathrin binding | 0.0923079381755934 | bayes_pls_golite062009 |
| nucleic acid binding | 0.0864051685617034 | bayes_pls_golite062009 |
| nucleoside-triphosphatase regulator activity | 0.0342115143082778 | bayes_pls_golite062009 |
| GTPase regulator activity | 0.0272200107208467 | bayes_pls_golite062009 |
| primary active transmembrane transporter activity | 0.0128158555898987 | bayes_pls_golite062009 |
| P-P-bond-hydrolysis-driven transmembrane transporter activity | 0.00672548245940896 | bayes_pls_golite062009 |
|
Region A: Residues: [533-731] |
1 11 21 31 41 51
| | | | | |
1 KSKLRPKMEE LVRINHLNYL KLGAVFRKPQ KSKSLAKLAF WHWKLDASEK MLTITGCDGE 60
61 NYVEGVQRDD IRQVWIKDIA DVTNNDEIDR KASSSRFTSS PSTQMLRGIR VQLKTTNDMK 120
121 EGEVLMALTS DETQSVIWLE GLAELIGSKA VKSETDAMVE RMLKMELRVR LLNVKLTNPE 180
181 EKPEIPPIPD DIKSFISKF
|
| Detection Method: | |
| Confidence: | 3.69897 |
| Match: | 1maiA |
| Description: | STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM PHOSPHOLIPASE C DELTA IN COMPLEX WITH INOSITOL TRISPHOSPHATE |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| binding | 2.65091781683225 | bayes_pls_golite062009 |
| protein binding | 2.12168271674167 | bayes_pls_golite062009 |
| GTPase regulator activity | 1.66986263418539 | bayes_pls_golite062009 |
| nucleoside-triphosphatase regulator activity | 1.64990514605397 | bayes_pls_golite062009 |
| signal transducer activity | 1.55319485371003 | bayes_pls_golite062009 |
| molecular transducer activity | 1.55319485371003 | bayes_pls_golite062009 |
| actin binding | 1.43478622851729 | bayes_pls_golite062009 |
| transporter activity | 1.28986800087234 | bayes_pls_golite062009 |
| small GTPase regulator activity | 1.2550809703725 | bayes_pls_golite062009 |
| enzyme regulator activity | 1.25381967078645 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 1.0982866925596 | bayes_pls_golite062009 |
| phospholipid binding | 1.09683218092034 | bayes_pls_golite062009 |
| Rac GTPase activator activity | 0.94335238962395 | bayes_pls_golite062009 |
| protein complex binding | 0.91954220321431 | bayes_pls_golite062009 |
| protein domain specific binding | 0.90578029954417 | bayes_pls_golite062009 |
| small GTPase binding | 0.8507658747425 | bayes_pls_golite062009 |
| GTPase binding | 0.82889812790119 | bayes_pls_golite062009 |
| guanyl-nucleotide exchange factor activity | 0.745321902095093 | bayes_pls_golite062009 |
| phosphoinositide binding | 0.71817045430443 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.54401901869178 | bayes_pls_golite062009 |
| receptor binding | 0.50127063593663 | bayes_pls_golite062009 |
| receptor activity | 0.353510125274044 | bayes_pls_golite062009 |
| actin filament binding | 0.34110357372875 | bayes_pls_golite062009 |
| transmembrane receptor activity | 0.207829786337892 | bayes_pls_golite062009 |
| lipid binding | 0.179561240451969 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase signaling protein activity | 0.13700176999256 | bayes_pls_golite062009 |
| receptor signaling protein activity | 0.10105990547756 | bayes_pls_golite062009 |
