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Protein Overview: ced-12

General Information:
Name(s) found: ced-12 / CE27228 [WormBase]
Description(s) found:
Found 22 descriptions.
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  • WBGene00000426 locus:ced-12 Cell death abnormality protein 12 status:Confirmed UniProt:Q8STE5 protein_id:CAD12890.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 731 amino acids

    Gene Ontology:
    Cellular Component: cytoskeleton [IEALink to PubMed article]
    plasma membrane [IDALink to PubMed article]
    Biological Process: gonad morphogenesis [IMPLink to PubMed article]
    phagocytosis [IEALink to PubMed article]
    actin filament organization [IDALink to PubMed article]
    engulfment of apoptotic cell [IMPLink to PubMed article]
    regulation of cell migration [IMPLink to PubMed article]
    cell migration [IMPLink to PubMed article]
    Molecular Function: SH3 domain binding [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAFHMPLKEL QPVDTSLPEH VVKGAVVIDK EFTIWNHRAV IPSNALHTVF ITINLLEQKL  60
   61 TDVVKMAARS MNLSEDDSYG LMADKPKRFI TDDNLNSLGS GFILTLCASP DHYVKRITEI 120
  121 LTEGNNISQM ENAVKTLDEF SLDPALIEAF YRCSSLELLF SLIRDDRVCM SSTLLSTCLR 180
  181 ALSSMLELAV GDFTWKSVPN DVVVSMASLV TGKAKREEAN TLLAALQMLE QLVIGDDTTR 240
  241 DWILEEVPIE TLIRHVEKSD ERIALCALSL MNSMIRRCPD DEKRFELIKS LEVVPFRNAV 300
  301 HSSLLRGGGG VRNLNAIEQL VEVQRSLISA YETSPPTDAE VQKILDIESS EDVSEEIREM 360
  361 WKSQIGEHRC GRLAAISMVQ FAEKSPQDLR MLISENTMRI EGGKWQLIPM WMRCCDIAAE 420
  421 LFRVIPGRDE LDRLIVVLFS TETPFPAVFA CIVHLFHRTW REMQAKGGEM EKVACVVLEQ 480
  481 LRHVLKRREI QDVEELSADL ETFSYRAMQE IWREEQLGKE NIQLHSEAVI QLKSKLRPKM 540
  541 EELVRINHLN YLKLGAVFRK PQKSKSLAKL AFWHWKLDAS EKMLTITGCD GENYVEGVQR 600
  601 DDIRQVWIKD IADVTNNDEI DRKASSSRFT SSPSTQMLRG IRVQLKTTND MKEGEVLMAL 660
  661 TSDETQSVIW LEGLAELIGS KAVKSETDAM VERMLKMELR VRLLNVKLTN PEEKPEIPPI 720
  721 PDDIKSFISK F

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..101] FFAS03 1.58 Crystal structure of mDIA1 GBD-FH3 in complex with RhoC-GMPPNP
    2 View Details [102..532] FFAS03 1.5 Crystal structure of the dimeric regulatory domain of mouse diaphaneous-related formin (DRF), mDia1
    3 View Details [533..731] PSI-BLAST 3.69897 STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM PHOSPHOLIPASE C DELTA IN COMPLEX WITH INOSITOL TRISPHOSPHATE

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transporter activity
    		•  2.3766833486706 bayes_pls_golite062009
  • binding
    		•  2.32095856197757 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.87445049214426 bayes_pls_golite062009
  • protein binding
    		•  1.61131270705552 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.2724388835449 bayes_pls_golite062009
  • protein transporter activity
    		•  1.10494977623322 bayes_pls_golite062009
  • signal transducer activity
    		•  1.07458868889742 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.07458868889742 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.80477645195818 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.632985761187158 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.260663498540354 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.187924119511902 bayes_pls_golite062009
  • clathrin binding
    		•  0.0923079381755934 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.0864051685617034 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.0342115143082778 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.0272200107208467 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.0128158555898987 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.00672548245940896 bayes_pls_golite062009
    3
    Term Confidence Notes
  • binding
    		•  2.65091781683225 bayes_pls_golite062009
  • protein binding
    		•  2.12168271674167 bayes_pls_golite062009
  • GTPase regulator activity
    		•  1.66986263418539 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  1.64990514605397 bayes_pls_golite062009
  • signal transducer activity
    		•  1.55319485371003 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.55319485371003 bayes_pls_golite062009
  • actin binding
    		•  1.43478622851729 bayes_pls_golite062009
  • transporter activity
    		•  1.28986800087234 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  1.2550809703725 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.25381967078645 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.0982866925596 bayes_pls_golite062009
  • phospholipid binding
    		•  1.09683218092034 bayes_pls_golite062009
  • Rac GTPase activator activity
    		•  0.94335238962395 bayes_pls_golite062009
  • protein complex binding
    		•  0.91954220321431 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.90578029954417 bayes_pls_golite062009
  • small GTPase binding
    		•  0.8507658747425 bayes_pls_golite062009
  • GTPase binding
    		•  0.82889812790119 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  0.745321902095093 bayes_pls_golite062009
  • phosphoinositide binding
    		•  0.71817045430443 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.54401901869178 bayes_pls_golite062009
  • receptor binding
    		•  0.50127063593663 bayes_pls_golite062009
  • receptor activity
    		•  0.353510125274044 bayes_pls_golite062009
  • actin filament binding
    		•  0.34110357372875 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.207829786337892 bayes_pls_golite062009
  • lipid binding
    		•  0.179561240451969 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase signaling protein activity
    		•  0.13700176999256 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  0.10105990547756 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle