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Protein Overview: dhs-4

General Information:
Name(s) found: dhs-4 / CE26900 [WormBase]
Description(s) found:
Found 17 descriptions.
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  • WBGene00000968 locus:dhs-4 status:Confirmed UniProt:O18030 protein_id:CAB04694.2 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 305 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEALink to PubMed article]
    Biological Process: estrogen biosynthetic process [IEALink to PubMed article]
    poly-hydroxybutyrate biosynthetic process [IEALink to PubMed article]
    metabolic process [IEALink to PubMed article]
    fatty acid biosynthetic process [IEALink to PubMed article]
    Molecular Function: estradiol 17-beta-dehydrogenase activity [IEALink to PubMed article]
    3-oxoacyl-[acyl-carrier-protein] reductase activity [IEALink to PubMed article]
    oxidoreductase activity [IEALink to PubMed article]
    NAD or NADH binding [IEALink to PubMed article]
    3-hydroxybutyrate dehydrogenase activity [IEALink to PubMed article]
    acetoacetyl-CoA reductase activity [IEALink to PubMed article]
    2-deoxy-D-gluconate 3-dehydrogenase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFDIILEIVI LLFNLLIQNL ISLIKYALPY SLLPKKDLYR KKVLITGAGN GLGKLLAQKF  60
   61 AARGATLILW DINLQSVDEL KNEIRGNQGE AHSYEVNLCD PGKIAQVGQQ VINDIGKVDI 120
  121 LVNNAGIATA KMILDSSENE INRSFDVNVK AHFYTVQQFL PAMLKDNNGH IVTIASAAGK 180
  181 MGSSGLADYS STKHAAVGFH DSLVAEIMES EKNGVKTTLV CPYYVHTSMF DATGAATRFP 240
  241 WIFPILDTDY VVQKIFEAIE TEQEFLVTPR AFYLVFAGIQ ILPYKAQAMV AQFFGLVQNL 300
  301 ERFHK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..305] PSI-BLAST 42.221849 Crystal structure of human 17-beta-hydroxysteroid dehydrogenase type XI

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • retinol dehydrogenase activity
    		•  2.50453100919665 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  2.01043991420942 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • alcohol dehydrogenase (NAD) activity
    		•  1.68027744358887 bayes_pls_golite062009
  • steroid dehydrogenase activity
    		•  1.63115363284582 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  1.37100865053801 bayes_pls_golite062009
  • steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.34764040278314 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors
    		•  1.25716430119828 bayes_pls_golite062009
  • fatty acid synthase activity
    		•  1.23679054027553 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  1.23588313472467 bayes_pls_golite062009
  • alcohol binding
    		•  1.07158175924364 bayes_pls_golite062009
  • binding
    		•  0.982999356179965 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.9367410227151 bayes_pls_golite062009
  • alcohol dehydrogenase activity, zinc-dependent
    		•  0.839863523675468 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  0.767938399969406 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.706900732268048 bayes_pls_golite062009
  • 3-oxoacyl-[acyl-carrier-protein] reductase activity
    		•  0.604742541607263 bayes_pls_golite062009
  • 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity
    		•  0.583772223704381 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  0.418775403210681 bayes_pls_golite062009
  • retinol binding
    		•  0.343379136183648 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  0.32207755075663 bayes_pls_golite062009
  • DNA binding
    		•  0.302492036575815 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.177044638410302 bayes_pls_golite062009
  • 3-hydroxyacyl-CoA dehydrogenase activity
    		•  0.120747628877723 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.100470710829263 bayes_pls_golite062009
  • NADPH:quinone reductase activity
    		•  0.0822919343613215 bayes_pls_golite062009
  • testosterone 17-beta-dehydrogenase activity
    		•  0.0770301180555719 bayes_pls_golite062009
  • ethanol binding
    		•  0.0448614072391299 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.51

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle