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View Structure Prediction Details

Protein: dhs-4
Organism: Caenorhabditis elegans
Length: 305 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for dhs-4.

Description E-value Query
Range		 Subject
Range
FABG_THEMA - 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Thermotoga maritima GN=fabG PE=3 SV=1
FABG_THEMA - 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Thermotoga maritima (strain ATCC 43589 / MSB8 / D...
 273.0 [0..36] [286..1]

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Predicted Domain #1
Region A:
Residues: [1-305] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFDIILEIVI LLFNLLIQNL ISLIKYALPY SLLPKKDLYR KKVLITGAGN GLGKLLAQKF  60
   61 AARGATLILW DINLQSVDEL KNEIRGNQGE AHSYEVNLCD PGKIAQVGQQ VINDIGKVDI 120
  121 LVNNAGIATA KMILDSSENE INRSFDVNVK AHFYTVQQFL PAMLKDNNGH IVTIASAAGK 180
  181 MGSSGLADYS STKHAAVGFH DSLVAEIMES EKNGVKTTLV CPYYVHTSMF DATGAATRFP 240
  241 WIFPILDTDY VVQKIFEAIE TEQEFLVTPR AFYLVFAGIQ ILPYKAQAMV AQFFGLVQNL 300
  301 ERFHK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 42.221849
Match: 1yb1A
Description: Crystal structure of human 17-beta-hydroxysteroid dehydrogenase type XI
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
retinol dehydrogenase activity 2.50453100919665 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor 2.01043991420942 bayes_pls_golite062009
catalytic activity 1.79741889688267 bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity 1.68027744358887 bayes_pls_golite062009
steroid dehydrogenase activity 1.63115363284582 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 1.37100865053801 bayes_pls_golite062009
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1.34764040278314 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors 1.25716430119828 bayes_pls_golite062009
fatty acid synthase activity 1.23679054027553 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH 1.23588313472467 bayes_pls_golite062009
alcohol binding 1.07158175924364 bayes_pls_golite062009
binding 0.982999356179965 bayes_pls_golite062009
oxidoreductase activity 0.9367410227151 bayes_pls_golite062009
alcohol dehydrogenase activity, zinc-dependent 0.839863523675468 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 0.767938399969406 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 0.706900732268048 bayes_pls_golite062009
3-oxoacyl-[acyl-carrier-protein] reductase activity 0.604742541607263 bayes_pls_golite062009
3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity 0.583772223704381 bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors 0.418775403210681 bayes_pls_golite062009
retinol binding 0.343379136183648 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.32207755075663 bayes_pls_golite062009
DNA binding 0.302492036575815 bayes_pls_golite062009
transcription regulator activity 0.177044638410302 bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity 0.120747628877723 bayes_pls_golite062009
nucleic acid binding 0.100470710829263 bayes_pls_golite062009
NADPH:quinone reductase activity 0.0822919343613215 bayes_pls_golite062009
testosterone 17-beta-dehydrogenase activity 0.0770301180555719 bayes_pls_golite062009
ethanol binding 0.0448614072391299 bayes_pls_golite062009
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