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Protein Overview: clp-7

General Information:
Name(s) found: clp-7 / CE25612 [WormBase]
Description(s) found:
Found 16 descriptions.
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  • WBGene00000547 locus:clp-7 status:Confirmed UniProt:Q9N4B1 protein_id:CCD72596.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 778 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEALink to PubMed article]
    Biological Process: cell death [IMPLink to PubMed article]
    proteolysis [IEALink to PubMed article]
    Molecular Function: cysteine-type endopeptidase activity [IEALink to PubMed article]
    calcium-dependent cysteine-type endopeptidase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDEEEYYEE DGGNDQGGED YNDDYGGGGG GGGGGYDDQN QFQEQDYGNE QNYGNQDYGQ  60
   61 GYGNQQDYGN QQDYQQQNYG GGGYDDEYQQ QDYQGGYDDS EQYEEQEEAE PEPEEQEDYS 120
  121 NDVEHSEEEE EEDDDDDGYT QAAANTNYGE NDGGNNENHG MGSLIKGAMD GFGGGGFDGV 180
  181 VGQIGSLISQ GGGGDSSGGL TNVFSSGGME SIVGNLISSA THQFFGINPA TGAIIGAIAG 240
  241 NIIFQMGGQN NSLSSIGKVV LDNIISGKFK RDVQPFTPGG GGGPGIGFQQ QFQTINFQQE 300
  301 RQRCLDQRCL FEDPQFPAND SSLYYKTRPD EPIIWKRPGE IYENPQLIVG EKSRFDVKQG 360
  361 ALGDCWLLAA VANLTLRDEL FYRVVPPDQS FTENYAGIFH FQFWRYGQWV DVVIDDRLPT 420
  421 VDGRLCYMRS QENNEFWSAL LEKAYAKLYG GYENLDGGST AEALEDFTGG LTEFFDISKG 480
  481 DKSTTLAMLV RGMQMGSLFG CSIDADENVK EAQLTNGLVR GHAYSITAIQ TVNTYGGQVP 540
  541 LLRIRNPWGN SKEWNGAWSD GSSEWSQVDP QQREQMGVQF AKDGEFWMSF DDFMTNFTQM 600
  601 ECCNLSADVM DEISEMTGVE VHDKQKHQWV EKSEDGEWNS RQGTAGGCQN NDTYCNNPQY 660
  661 GTYFQVPMDS VEHDGKCTVI GAVLQKYRRE LRTKGLDNLP IGFSVYKADG SGQAIHDVSG 720
  721 QKPIARTKVF INMREVTVRF RVPPGQYVIV PCTFDAHDDA SFLLRIFSNA EFQTTRLR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run hcp-1 hcp1 IP from december2004 Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..112] deduced N/A No confident structure predictions are available.
    2 View Details [113..281] PSI-BLAST 4.0 Sec24
    3 View Details [282..778] PSI-BLAST 180.0 Calpain large subunit, C-terminal domain (domain IV); Calpain large subunit, middle domain (domain III); Calpain large subunit, catalytic domain (domain II)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • peptidase activity
    		•  3.28868056127375 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  3.05412701733177 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  3.01472402774099 bayes_pls_golite062009
  • hydrolase activity
    		•  2.29464693834116 bayes_pls_golite062009
  • endopeptidase activity
    		•  2.26699762664334 bayes_pls_golite062009
  • cysteine-type endopeptidase activity
    		•  1.95802900199539 bayes_pls_golite062009
  • binding
    		•  1.77258741259391 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  1.07520173658976 bayes_pls_golite062009
  • catalytic activity
    		•  1.05972260874031 bayes_pls_golite062009
  • protein binding
    		•  0.896934807256194 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.833714375875501 bayes_pls_golite062009
  • calcium ion binding
    		•  0.687204894708051 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  0.495368836247989 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.313326619937245 bayes_pls_golite062009
  • calcium-dependent cysteine-type endopeptidase activity
    		•  0.196538841514154 bayes_pls_golite062009
  • DNA binding
    		•  0.053663265361386 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.49

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle