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Protein Overview: clp-6

General Information:
Name(s) found: clp-6 / CE25611 [WormBase]
Description(s) found:
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  • WBGene00000546 locus:clp-6 status:Partially_confirmed UniProt:Q9N4B2 protein_id:CCD72595.1 [WormBase]
  • gi|7105696|gb|AAF36079.1| Calpain family protein 6, partially confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • gi|17544252|ref|NP_500081.1| CaLPain family member (clp-6) [Caenorhabditis elegans] [NCBI NR]
  • [wormpep67.fasta]
  • CE25611 WBGene00000546 locus:clp-6 status:Predicted TR:Q9N4B2 protein_id:AAF36079.1 [wormpep150.fasta]
  • 25611 WBGene00000546 locus:clp-6 status:Predicted TR:Q9N4B2 protein_id:AAF36079.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • CaLPain family member (clp-6) [Caenorhabditis elegans]gi|7105696|gb|AAF36079.1| Calpain family protein 6 [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas]
  • locus:clp-6 status:Predicted TR:Q9N4B2 protein_id:AAF36079.1 [wormpep115.fasta.reversed]
  • CE25611 locus:clp-6 status:Predicted [wormpep80.hongbin]
  • CE25611 WBGene00000546 locus:clp-6 status:Partially_confirmed UniProt:Q9N4B2_CAEEL protein_id:AAF36079.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE25611 WBGene00000546 locus:clp-6 status:Partially_confirmed UniProt:Q9N4B2_CAEEL protein_id:AAF36079.1| [wormORF-contam.fasta]
  • Calpain family protein 6 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CaLPain family member (clp-6) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE25611 WBGene00000546 locus:clp-6 status:Partially_confirmed TR:Q9N4B2 protein_id:AAF36079.1 [WormBase_C-elegans_wp180_08-19-2007_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE25611 WBGene00000546 locus:clp-6 status:Partially_confirmed UniProt:Q9N4B2 protein_id:AAF36079.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • CE25611 WBGene00000546 locus:clp-6 status:Partially_confirmed UniProt:Q9N4B2 protein_id:CCD72595.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
    • Organism: Caenorhabditis elegans
    Length: 790 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEALink to PubMed article]
    Biological Process: cell death [IMPLink to PubMed article]
    proteolysis [IEALink to PubMed article]
    Molecular Function: cysteine-type endopeptidase activity [IEALink to PubMed article]
    calcium-dependent cysteine-type endopeptidase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDEEVLNNE DEQEENINNN NLPSIVKEFV SDYTGSIWDE LLRQLTALIP RDSSGRGLTN  60
   61 IFSSGALESL VGNLISNASH EFFGVNSENG EIIGALAGNA MFNLGGENNS LSSIGKVVLD 120
  121 NIVSGKFKRE CHSYVPLKCQ PLYFYEERQK CLDENRLFED PQFPANNSSI YYKKPPKSHI 180
  181 VWLRPAKIFA NPRLIVNGKS RFDVRQGSLG NCWFLAAAAT LAQRDELFYR VVPPDQSFTE 240
  241 NYAGIFHFQF WRYGEWVDVV IDDRLPTVNG KLIYMSSQDG DECWGPLLEK AYAKLYGTYE 300
  301 HLDGGTTTEA LEDFTGGLTE FYDLTSTDKT MILAMIMKGM QMGSLFACSI DPDPREKEAQ 360
  361 LANGLVRGHA YSVTGVHTVE TDKEKVALLR IRNPWGDTEW NGDWSDKSSL WEQVDQEQRE 420
  421 KMEFRIKEDG EFWMCLDDFM AQFANLDCCN LSADVMHEIT EMTEIEVMEK QSKQWIQKSA 480
  481 DGEWCSRKGT AGGCSNNENT FCTNPQYETY FRATSPSSND KCTVIAAVFQ KYRRNQLHRG 540
  541 LDMLQIGLSV YKMSGPNEKV TAEMMKTHAP IASTKLFVDY REAVVRFTVP PGYYVIVPCT 600
  601 FEPNHDAEFL LRTFSNVEFD KTDMHFIWKS AVFLCALLAI NFPLTKSSID LHSHEKVQIS 660
  661 INNTSGPRKQ VRIRFPEFII SGHIFCNGAP KRWLHPQLST PKNPDEYFNI VTTDAAGMYF 720
  721 LTTGNHFDLD RSVIITVLHQ CEMKHLHPEP CALPYYKTVI PFNSTSSSTT YIRRDLELSK 780
  781 MEAFSSTHCL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..119] deduced N/A No confident structure predictions are available.
    2 View Details [120..790] PSI-BLAST 1000.0 Crystal Structure of a mu-like calpain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • peptidase activity
    		•  3.28868056127375 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  3.05412701733177 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  3.01472402774099 bayes_pls_golite062009
  • hydrolase activity
    		•  2.29464693834116 bayes_pls_golite062009
  • endopeptidase activity
    		•  2.26699762664334 bayes_pls_golite062009
  • cysteine-type endopeptidase activity
    		•  1.95802900199539 bayes_pls_golite062009
  • binding
    		•  1.77258741259391 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  1.07520173658976 bayes_pls_golite062009
  • catalytic activity
    		•  1.05972260874031 bayes_pls_golite062009
  • structural constituent of muscle
    		•  1.03279885297458 bayes_pls_golite062009
  • protein binding
    		•  0.896934807256194 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.833714375875501 bayes_pls_golite062009
  • actin binding
    		•  0.816212666861836 bayes_pls_golite062009
  • calcium ion binding
    		•  0.687204894708051 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  0.495368836247989 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.313326619937245 bayes_pls_golite062009
  • calcium-dependent cysteine-type endopeptidase activity
    		•  0.196538841514154 bayes_pls_golite062009
  • DNA binding
    		•  0.053663265361386 bayes_pls_golite062009
  • motor activity
    		•  0.0206797712755302 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.83

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle