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View Structure Prediction Details

Protein: clp-6
Organism: Caenorhabditis elegans
Length: 790 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for clp-6.

Description E-value Query
Range
Subject
Range
gi|8132991, gi|4... - gi|8132991|gb|AAF73443.1|AF263609_1 micromolar calcium-activated neutral protease 1 isoform B; CAPN1...
680.0 [0..122] [746..20]

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Predicted Domain #1
Region A:
Residues: [1-119]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDEEVLNNE DEQEENINNN NLPSIVKEFV SDYTGSIWDE LLRQLTALIP RDSSGRGLTN  60
   61 IFSSGALESL VGNLISNASH EFFGVNSENG EIIGALAGNA MFNLGGENNS LSSIGKVVL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [120-790]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNIVSGKFKR ECHSYVPLKC QPLYFYEERQ KCLDENRLFE DPQFPANNSS IYYKKPPKSH  60
   61 IVWLRPAKIF ANPRLIVNGK SRFDVRQGSL GNCWFLAAAA TLAQRDELFY RVVPPDQSFT 120
  121 ENYAGIFHFQ FWRYGEWVDV VIDDRLPTVN GKLIYMSSQD GDECWGPLLE KAYAKLYGTY 180
  181 EHLDGGTTTE ALEDFTGGLT EFYDLTSTDK TMILAMIMKG MQMGSLFACS IDPDPREKEA 240
  241 QLANGLVRGH AYSVTGVHTV ETDKEKVALL RIRNPWGDTE WNGDWSDKSS LWEQVDQEQR 300
  301 EKMEFRIKED GEFWMCLDDF MAQFANLDCC NLSADVMHEI TEMTEIEVME KQSKQWIQKS 360
  361 ADGEWCSRKG TAGGCSNNEN TFCTNPQYET YFRATSPSSN DKCTVIAAVF QKYRRNQLHR 420
  421 GLDMLQIGLS VYKMSGPNEK VTAEMMKTHA PIASTKLFVD YREAVVRFTV PPGYYVIVPC 480
  481 TFEPNHDAEF LLRTFSNVEF DKTDMHFIWK SAVFLCALLA INFPLTKSSI DLHSHEKVQI 540
  541 SINNTSGPRK QVRIRFPEFI ISGHIFCNGA PKRWLHPQLS TPKNPDEYFN IVTTDAAGMY 600
  601 FLTTGNHFDL DRSVIITVLH QCEMKHLHPE PCALPYYKTV IPFNSTSSST TYIRRDLELS 660
  661 KMEAFSSTHC L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1000.0
Match: 1qxpA
Description: Crystal Structure of a mu-like calpain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 3.28868056127375 bayes_pls_golite062009
cysteine-type peptidase activity 3.05412701733177 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 3.01472402774099 bayes_pls_golite062009
hydrolase activity 2.29464693834116 bayes_pls_golite062009
endopeptidase activity 2.26699762664334 bayes_pls_golite062009
cysteine-type endopeptidase activity 1.95802900199539 bayes_pls_golite062009
binding 1.77258741259391 bayes_pls_golite062009
small conjugating protein-specific protease activity 1.07520173658976 bayes_pls_golite062009
catalytic activity 1.05972260874031 bayes_pls_golite062009
structural constituent of muscle 1.03279885297458 bayes_pls_golite062009
protein binding 0.896934807256194 bayes_pls_golite062009
cytoskeletal protein binding 0.833714375875501 bayes_pls_golite062009
actin binding 0.816212666861836 bayes_pls_golite062009
calcium ion binding 0.687204894708051 bayes_pls_golite062009
ubiquitin-specific protease activity 0.495368836247989 bayes_pls_golite062009
nucleic acid binding 0.313326619937245 bayes_pls_golite062009
calcium-dependent cysteine-type endopeptidase activity 0.196538841514154 bayes_pls_golite062009
DNA binding 0.053663265361386 bayes_pls_golite062009
motor activity 0.0206797712755302 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle