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Protein Overview: sma-4

General Information:
Name(s) found: sma-4 / CE25077 [WormBase]
Description(s) found:
Found 18 descriptions.
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  • WBGene00004858 locus:sma-4 Dwarfin sma-4 status:Confirmed UniProt:P45897 protein_id:CCD73313.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 565 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEALink to PubMed article]
    Biological Process: dauer larval development [IGILink to PubMed article]
    positive regulation of cell size [IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    positive regulation of organ growth [IMPLink to PubMed article]
    tail tip morphogenesis [IGILink to PubMed article][IMPLink to PubMed article]
    positive regulation of protein catabolic process [IMPLink to PubMed article]
    regulation of transcription, DNA-dependent [IEALink to PubMed article]
    positive regulation of multicellular organism growth [IGILink to PubMed article][IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSQPSTSNQ MYYDPLYGAE QIVQCNPMDY HQANILCGMQ YFNNSHNRYP LLPQMPPQFT  60
   61 NDHPYDFPNV PTISTLDEAS SFNGFLIPSQ PSSYNNNNIS CVFTPTPCTS SQASSQPPPT 120
  121 PTVNPTPIPP NAGAVLTTAM DSCQQISHVL QCYQQGGEDS DFVRKAIESL VKKLKDKRIE 180
  181 LDALITAVTS NGKQPTGCVT IQRSLDGRLQ VAGRKGVPHV VYARIWRWPK VSKNELVKLV 240
  241 QCQTSSDHPD NICINPYHYE RVVSNRITSA DQSLHVENSP MKSEYLGDAG VIDSCSDWPN 300
  301 TPPDNNFNGG FAPDQPQLVT PIISDIPIDL NQIYVPTPPQ LLDNWCSIIY YELDTPIGET 360
  361 FKVSARDHGK VIVDGGMDPH GENEGRLCLG ALSNVHRTEA SEKARIHIGR GVELTAHADG 420
  421 NISITSNCKI FVRSGYLDYT HGSEYSSKAH RFTPNESSFT VFDIRWAYMQ MLRRSRSSNE 480
  481 AVRAQAAAVA GYAPMSVMPA IMPDSGVDRM RRDFCTIAIS FVKAWGDVYQ RKTIKETPCW 540
  541 IEVTLHRPLQ ILDQLLKNSS QFGSS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..61] MSA 1.052992 View MSA. No confident structure predictions are available.
    2 View Details [62..128] MSA 1.05699 View MSA. No confident structure predictions are available.
    3 View Details [129..335] PSI-BLAST 50.69897 Crystal structure of Smad3-MH1 bound to DNA at 2.4 A resolution
    4 View Details [336..565] PSI-BLAST 82.09691 Crystal Structure of the phosphorylated Smad2/Smad4 heterotrimeric complex

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • SMAD binding
    		•  9.3718253521769 bayes_pls_golite062009
  • R-SMAD binding
    		•  9.05113862383896 bayes_pls_golite062009
  • transforming growth factor beta receptor, cytoplasmic mediator activity
    		•  5.17758651944685 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase signaling protein activity
    		•  4.95270065635384 bayes_pls_golite062009
  • co-SMAD binding
    		•  4.57538059815089 bayes_pls_golite062009
  • transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
    		•  4.49077041445033 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  4.40792626415753 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  4.11302084276027 bayes_pls_golite062009
  • binding
    		•  3.6561903894619 bayes_pls_golite062009
  • transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
    		•  3.61855740138956 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.49687772656017 bayes_pls_golite062009
  • protein binding
    		•  3.44553762357492 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.3543221973342 bayes_pls_golite062009
  • signal transducer activity
    		•  3.3543221973342 bayes_pls_golite062009
  • DNA binding
    		•  3.30334070294767 bayes_pls_golite062009
  • type I transforming growth factor beta receptor binding
    		•  3.25693690222359 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.21526555447097 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  3.11943104361829 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  3.08220855629618 bayes_pls_golite062009
  • transcription activator activity
    		•  2.94935902482394 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  2.94401714632865 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.88406197124131 bayes_pls_golite062009
  • activin binding
    		•  2.85561990563659 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.61166537801555 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase binding
    		•  2.57320437127906 bayes_pls_golite062009
  • transforming growth factor beta receptor binding
    		•  2.57320437127906 bayes_pls_golite062009
  • phosphatase activity
    		•  2.46582579847871 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  2.41505949322677 bayes_pls_golite062009
  • promoter binding
    		•  2.30493918456602 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.1294440466744 bayes_pls_golite062009
  • transcription factor activity
    		•  2.08449567315174 bayes_pls_golite062009
  • collagen binding
    		•  1.9825610927799 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.88096476099716 bayes_pls_golite062009
  • kinase activity
    		•  1.82476774968305 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.74929788315626 bayes_pls_golite062009
  • protein kinase activity
    		•  1.73373132141588 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.66058356077795 bayes_pls_golite062009
  • transforming growth factor beta receptor, common-partner cytoplasmic mediator activity
    		•  1.61493700485683 bayes_pls_golite062009
  • I-SMAD binding
    		•  1.6033600450778 bayes_pls_golite062009
  • chromatin binding
    		•  1.44267609273288 bayes_pls_golite062009
  • small conjugating protein binding
    		•  1.3559369584113 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.32552524966562 bayes_pls_golite062009
  • transferase activity
    		•  1.29860325699399 bayes_pls_golite062009
  • ubiquitin binding
    		•  1.28191134965346 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.21988722144674 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  1.1868962075754 bayes_pls_golite062009
  • receptor binding
    		•  1.1261895404991 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  1.10293974101617 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  1.02636679142543 bayes_pls_golite062009
  • histone binding
    		•  1.01074250987871 bayes_pls_golite062009
  • transcription factor binding
    		•  0.95553719139833 bayes_pls_golite062009
  • ubiquitin protein ligase binding
    		•  0.85140744915405 bayes_pls_golite062009
  • hydrolase activity
    		•  0.711787881321496 bayes_pls_golite062009
  • RNA binding
    		•  0.403713641965787 bayes_pls_golite062009
  • enzyme binding
    		•  0.34998623523914 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.33340925100096 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.15013949452504 bayes_pls_golite062009
  • identical protein binding
    		•  0.0513801649373811 bayes_pls_golite062009
  • protein homodimerization activity
    		•  0.0339057097360133 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.83

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle