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Protein Overview: vps-34

General Information:
Name(s) found: vps-34 / CE24760 [WormBase]
Description(s) found:
Found 17 descriptions.
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  • WBGene00006932 locus:vps-34 Phosphatidylinositol 3-kinase status:Confirmed UniProt:Q9TXI6 protein_id:CCD61195.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 650 amino acids

    Gene Ontology:
    Cellular Component: phosphoinositide 3-kinase complex [IEALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    nuclear outer membrane [IDALink to PubMed article]
    Biological Process: nuclear envelope organization [IMPLink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    regulation of protein secretion [IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed articleLink to PubMed article]
    phosphoinositide-mediated signaling [IEALink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed articleLink to PubMed article]
    ecdysis, collagen and cuticulin-based cuticle [IMPLink to PubMed article]
    phosphoinositide phosphorylation [IEALink to PubMed article]
    regulation of endocytosis [IMPLink to PubMed article]
    reproduction [IMPLink to PubMed article]
    growth [IMPLink to PubMed article]
    Molecular Function: inositol or phosphatidylinositol kinase activity [IEALink to PubMed article]
    phosphotransferase activity, alcohol group as acceptor [IEALink to PubMed article]
    1-phosphatidylinositol-3-kinase activity [IDALink to PubMed article][IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRVSTSVNGG VGIVSACTRY CVADPELLLE SLAEVKHSAM TRRIRDVEDE RHRQVKPNKQ  60
   61 AKDRLETIVN LPSSQVLTRE QRDLVWKFRH YLRQFPKALN KYLRSVNWVH PQEVKTALAL 120
  121 MNDWELIEAE DALELLSSAF THPAVRAYSV SRLLEAASPE QVLLYLPQLV QALKYEQGQQ 180
  181 LPEEGNPVPV VSEEEGKIPS VATTPTEELE GRDMTVVTKK EARKAASGDL ATFLIDYALA 240
  241 SPKVSNYLYW HLKTEIESTK ESKEEHSKMY QNIQDRLMEA LVKRPDTRAQ VDSLHQQQIF 300
  301 VEDLIILMNE AKARGGRLNE SKSAEFRTML SRAKHMLDLK GVHLPLDPSF RLSSVIPDTA 360
  361 SFFKSEMMPA KISFKVLQPN GKADRNIPEE YTVIFKTGDD LRQDQLIQQM VRLIDIILKK 420
  421 GQLDLKLTPY LVLSTGVGQG FVQCIKSKPL RAIQEQYKAH KMDCIREAMK ELRPGDGPFG 480
  481 IEPNVIDNYV RSLAGYSVIM YILGLGDRHL DNLLLCENGK LFHVDFGFIL GRDPKPMPPP 540
  541 MKLTSEMVQV MGGVKSKQFL EFVQHVDSAY RILRRHSNVL LNLFSLMLDA GIPDIAAEPD 600
  601 KAIFKIEQRL RLDLSDEAAT KHIFTQIESS LNAKMAMISD IIHAYKQNLM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..650] PSI-BLAST 120.0 Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • protein kinase activity
    		•  5.17195961442593 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • 1-phosphatidylinositol-3-kinase activity
    		•  3.36507457832455 bayes_pls_golite062009
  • phosphoinositide 3-kinase activity
    		•  3.35431422298319 bayes_pls_golite062009
  • lipid kinase activity
    		•  3.32869674544617 bayes_pls_golite062009
  • inositol or phosphatidylinositol kinase activity
    		•  3.07779388034304 bayes_pls_golite062009
  • binding
    		•  2.31930216202447 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.79921740914853 bayes_pls_golite062009
  • signal transducer activity
    		•  1.79921740914853 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • protein binding
    		•  1.22565748038754 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • profilin binding
    		•  0.635898406235221 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.58590430118616 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.5066845540941 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • phospholipid binding
    		•  0.304184566966103 bayes_pls_golite062009
  • phosphatidylinositol-4,5-bisphosphate 3-kinase activity
    		•  0.147483323744488 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.0556163711947139 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.00652065412910241 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.64

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle